Abstract
The very early embryonic vascular system develops from mesodermal blood islands and is laid down prior to the onset of circulation. According to Risau (1990), all subsequent angiogenic events seem to be regulated by the capillary requirements of surrounding tissues. Whether such a view holds true for the development of cartilage (and subsequently bone) during early limb development is controversial, with two opposing views being expressed. The first suggests that the developing vasculature dictates the spatial pattern of cell differentiation in the limb, whilst the other suggests that the vasculature is passive, simply responding to the requirements of tissues as they differentiate. In this paper these two views of the limb vasculature will be assessed with reference to factors which may govern blood vessel growth in the developing limb.
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Wilson, D.J. (1991). Vascular Involvement in Cartilage and Bone Development. In: Hinchliffe, J.R., Hurle, J.M., Summerbell, D. (eds) Developmental Patterning of the Vertebrate Limb. NATO ASI Series, vol 205. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3310-8_32
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DOI: https://doi.org/10.1007/978-1-4615-3310-8_32
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