Abstract
The very early embryonic vascular system develops from mesodermal blood islands and is laid down prior to the onset of circulation. According to Risau (1990), all subsequent angiogenic events seem to be regulated by the capillary requirements of surrounding tissues. Whether such a view holds true for the development of cartilage (and subsequently bone) during early limb development is controversial, with two opposing views being expressed. The first suggests that the developing vasculature dictates the spatial pattern of cell differentiation in the limb, whilst the other suggests that the vasculature is passive, simply responding to the requirements of tissues as they differentiate. In this paper these two views of the limb vasculature will be assessed with reference to factors which may govern blood vessel growth in the developing limb.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Antonelli-Orlidge, A., Saunders, K. B., Smith, S. R., and D’Amore, P. A., 1989, An activated form of transforming growth factor-beta is produced by cultures of endothelial cells and pericytes, proc Nat Acad Sci., 86:4544
Caplan, A. I., and Koutroupas, S., 1973, The control of muscle and cartilage development in the chick embryo: the role of differential vascularisation, J Embryol exp Morphol., 29:571.
Caplan, A. I., and Pechak, D. G., 1987, The cellular and molecular biology of bone formation, in: “Bone and Mineral Research”, W.A. Peck, ed., Elsevier Science Publishers, New York.
Drushel, R. F., Pechak, D. G., and Caplan, A. I., 1985, The anatomy, ultrastructure and fluid dynamics of the developing vasculature of the embryonic chick wing bud, Cell Diff., 16:13.
Feinberg, R. N., Latker, C. H., and Beebe, D. C, 1986, Localised vascular regression during limb morphogenesis in the chicken embryo. I. Spatial and termporal changes in the vascular pattern, Anat Rec., 214:405.
Folkman, J., 1974, Tumour angiogenesis, Adv Cancer Res, 19: 331–358.
Hallmann, R., Feinberg, R. N., Latker, C. H., Sasse, J., and Risau, W., 1987, Regression of blood vessels precedes cartilage differentiation during chick limb development, Differentiation, 34:98.
Hamburger, V., and Hamilton, H. L., 1951, A series of normal stages in the development of the chick embryo, J Morphol., 88:49.
Hunter, S and Caplan, A. I., 1983, Control of cartilage differentiation. in “Cartilage: Development, Differetiation and Growth”, B.K Hall, ed., Academic Press, New York.
Hwang, P. M., Byrne, D. H., and Kitos, P. A., 1988. Effects of molecular oxygen on chick limb bud chondrogenesis, Differentiation. 37:14.
Jargiello, D. M., and Caplan, A. I., 1983, The establishment of vascular-derived micro-environments in the developing chick wing, Dev Biol., 97:364.
Knighton, D. R., Hunt, T. K., Scheuenstuhl, H., Halliday, B. J., Werb, Z., and Carr, J., 1983, Oxygen tension regulates the expression of angiogenesis factors by macrophages, Science, 221:1283.
Levinsohn, E. M., Pakard, D. S., West, E. M., and Hootnick, D. R., 1984, The arterial anatomy of the hatchling chick, Am J Anat., 169:377.
McLaughlin, J., Bateman, M., and Wolpert, L., 1976, Effect of 3-Acetylpyridine on tissue differentiation of the embryonic chick limb. Nature, 264:267.
Oikawa, T., Hirotani, K., Nakamura, O., Shudo, K., Hiragun, A., and Iwaguchi, T., 1989, A highly potent antiangiogenic activity of retinoids. Cancer Lett., 48:157.
Pechak, D. G., Kujawa, M. J and Caplan, A. I 1986a, Morphological and histochemical events during first bone formation in embryonic chick limbs, Bone, 7:441.
Pechak, D. G., Kujawa, M. J., and Caplan, A. I., 1986b, Morphology of bone development and bone remodelling in embryonic chick limbs, Bone, 7:459.
Risau, W., 1986, Developing brain produces an angiogenesis factor, Proc Nat Acad Sci., 83:3855.
Risau, W and Ekblom, P., 1986, Production of a heparin-binding angiogenesis factor by the embryonic kidney, J Cell Biol.,103:1101.
Risau, W., 1990, Angiogenic growth factors, Prog Growth Factor Res., 2:71.
Stewart, R. A, Nelson, J and Wilson, D. J.,1989, Epidermal growth factor promotes chick embryonic angiogenesis Cell Biol Int Rao., 13:957.
Stewart, R. A, Nelson, J and Wilson, D. J.,1990 Growth of the chick areain ovo and in shell-less culture. J Anat., 172:81.
Summerbell, D., 1976, A descriptive study of the rate of elongation and differentiation of the developing chick wing,J Embryol exp Morph., 35:241.
Thompson T.J., Owens P. D. A., and Wilson D.J., 1989, Intramembranous osteogenesis and angiogenesis in the chick embryo. J Anat., 166:55.
Wilson, D. J., 1983, The origin of the endothelium in the developing marginal vein of the chick wing bud. Cell Diff., 13:63.
Wilson, D. J.,1986, Development of avascularity during cartilage differentiation in the embryonic limb - An exclusion model. Differentiation, 30:183.
Wilson, D. J., and Orr-Urtereger, A., 1986, Aspects of vascular differentiation in the developing chick wing. Acta Histocher, 32S:1
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Wilson, D.J. (1991). Vascular Involvement in Cartilage and Bone Development. In: Hinchliffe, J.R., Hurle, J.M., Summerbell, D. (eds) Developmental Patterning of the Vertebrate Limb. NATO ASI Series, vol 205. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3310-8_32
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3310-8_32
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6457-3
Online ISBN: 978-1-4615-3310-8
eBook Packages: Springer Book Archive