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Sugar Chains

Decoding the Functions of Glycans

  • Book
  • © 2015

Overview

Editors:
  1. Tadashi Suzuki

    1. Glycometabolome Team, Systems Glycobiology Research Group, RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN Global Research Cluster, Wako, Japan

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  2. Kazuaki Ohtsubo

    1. Department of Analytical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

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  3. Naoyuki Taniguchi

    1. Disease Glycomics Team, Systems Glycobiology Research Group, RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN Global Research Cluster, Wako, Japan

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  • Covers cutting-edge results from diverse research fields such as cell biology, immunology, and cancer biology
  • Clarifies the roles of glycans in various cellular processes and diseases
  • Suggests future directions for further understanding of the functions of glycans
  • Is recommended for researchers who are not expert in glycoscience

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-viii
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  2. N-Glycans and Quality Control of Proteins

    • Nobuko Hosokawa, Tadashi Suzuki
    Pages 1-20

  3. Glycan-Mediated Protein Transport from the Endoplasmic Reticulum

    • Morihisa Fujita, Xiao-Dong Gao, Taroh Kinoshita
    Pages 21-34

  4. Gangliosides and T-Cell Immunity

    • Masakazu Nagafuku, Jin-ichi Inokuchi
    Pages 35-54

  5. Gangliosides Regulate Tumor Properties: With Focus on the Suppression of Metastasis-Associated ppGalNAc-T13 with GM1

    • Koichi Furukawa, Yasuyuki Matsumoto, Qing Zhang, Keiko Furukawa
    Pages 55-70

  6. Role of Glycans in Viral Infection

    • Tadanobu Takahashi, Takashi Suzuki
    Pages 71-93

  7. Discovery and Applications of a Novel Human Pluripotent Stem Cell-Specific Lectin Probe rBC2LCN

    • Hiroaki Tateno, Jun Hirabayashi
    Pages 95-106

  8. Glycan Structure and Neural Plasticity

    • Tadahisa Mikami, Hiroshi Kitagawa
    Pages 107-126

  9. The Involvement of Midkine, a Heparin-Binding Growth Factor, in Cancer Development

    • Satoshi Kishida, Kenji Kadomatsu
    Pages 127-138

  10. Tumor-Associated Glycans and Their Functional Roles in the Multistep Process of Human Cancer Progression

    • Reiji Kannagi, Keiichiro Sakuma, Bi-He Cai, Shin-Yi Yu
    Pages 139-158

  11. Mammalian Sialidase and Tumor Development

    • Taeko Miyagi, Kohta Takahashi, Kazuhiro Shiozaki, Kazunori Yamaguchi
    Pages 159-176

  12. Roles of Glycans in Immune Evasion from NK Immunity

    • Shigeru Tsuboi
    Pages 177-188

  13. Glycomic Analysis of Cancer

    • Yasuhide Miyamoto
    Pages 189-207

  14. Glyco-Predisposing Factor of Diabetes

    • Kazuaki Ohtsubo
    Pages 209-218

  15. Macrophages Govern Ganglioside GM3 Expression in Adipocytes to Regulate Adipogenesis and Insulin Signaling in Homeostatic and Pathogenic Conditions

    • Jin-ichi Inokuchi
    Pages 219-234

  16. O-Mannosyl Glycan and Muscular Dystrophy

    • Hiroshi Manya, Tamao Endo
    Pages 235-258

  17. Glycans and Chronic Obstructive Pulmonary Disease (COPD)

    • Congxiao Gao, Naoyuki Taniguchi
    Pages 259-266

  18. α1,6-Fucosyltransferase Knockout Mice and Schizophrenia-Like Phenotype

    • Wei Gu, Tomohiko Fukuda, Jianguo Gu
    Pages 267-280

  19. Erratum: Chapter 5 Role of Glycans in Viral Infection

    • Tadanobu Takahashi, Takashi Suzuki
    Pages E1-E1

  20. Back Matter

    Pages 281-288
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Keywords

About this book

This book presents the latest breakthrough results in glycobiology regarding the roles of glycans in relation to quality control and transport of protein, the immune system, viral infection, stem cells, the neural system, and various diseases such as cancer, diabetes, chronic obstructive pulmonary disease, muscular dystrophy, and schizophrenia. Although glycoscience has long been regarded as a very specialized field with no simple analytical method, the recent explosive progress in research continues to provide limitless evidence that glycan chains are the key component in various biological phenomena. Cell surface glycans, for example, change with developmental stages or environmental conditions and thus represent a “face” of the cell that is utilized for identification of iPS and ES cells and as biomarkers in diagnosis or detection of cancer. This book comprises 17 chapters, each of which poses outstanding “glyco-related” questions enabling non-specialists to have a clearer idea about what the future direction for further investigation of glycans in their own research fields will be. Also including basic information to understand the nature of glycans, this title serves as an excellent “textbook” for researchers in diverse research fields who are not familiar with, but nevertheless interested in, glycan chains or sugar chains.

Editors and Affiliations

  • Glycometabolome Team, Systems Glycobiology Research Group, RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN Global Research Cluster, Wako, Japan

    Tadashi Suzuki

  • Department of Analytical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

    Kazuaki Ohtsubo

  • Disease Glycomics Team, Systems Glycobiology Research Group, RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN Global Research Cluster, Wako, Japan

    Naoyuki Taniguchi

Bibliographic Information

  • Book Title: Sugar Chains

  • Book Subtitle: Decoding the Functions of Glycans

  • Editors: Tadashi Suzuki, Kazuaki Ohtsubo, Naoyuki Taniguchi

  • DOI: https://doi.org/10.1007/978-4-431-55381-6

  • Publisher: Springer Tokyo

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Japan 2015

  • Hardcover ISBN: 978-4-431-55380-9Published: 09 March 2015

  • Softcover ISBN: 978-4-431-56378-5Published: 09 October 2016

  • eBook ISBN: 978-4-431-55381-6Published: 02 February 2015

  • Edition Number: 1

  • Number of Pages: VIII, 288

  • Number of Illustrations: 46 b/w illustrations, 41 illustrations in colour

  • Topics: Biochemistry, general, Cancer Research, Immunology

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