Cyclosporin

Mode of Action and Clinical Applications

  • Angus W. Thomson

Table of contents

  1. Front Matter
    Pages i-x
  2. Iris Motta, Paolo Truffa-Bachi
    Pages 34-49
  3. Susan M. L. Lim, David J. G. White
    Pages 82-111
  4. Michael C. Jones, Graeme R. D. Catto
    Pages 112-144
  5. Kerry Atkinson
    Pages 145-158
  6. John V. Forrester, Janet Liversidge, Hamish M. Towler
    Pages 159-180
  7. Jean-François Bach
    Pages 181-190
  8. Anne V. Powles, Barbara S. Baker, Lionel Fry
    Pages 191-212
  9. Beat von Graffenried, David Friend, Nicholas Shand, Wilfried Scheiss, Pentti Timonen
    Pages 213-251
  10. Joachim Grevel, Barry D. Kahan
    Pages 252-266
  11. M. Danny Burke, Fiona Macintyre, D. Cameron, Paul H. Whiting
    Pages 267-302
  12. Paul H. Whiting, Angus W. Thompson
    Pages 303-323
  13. Back Matter
    Pages 365-372

About this book

Introduction

Cyclosporin has had a remarkable effect on clinical organ transplantation. Prior to its introduction, considerable advances had been made in the grafting of vital organs, particularly the kidney, heart and liver. In many developed countries, however, transplantation was not considered wo-rthwhile in terms of gain for the investment of resources. The improved results of kidney grafts following the use of cyclosporin has changed this attitude. For all types of organ transplantation, cyclosporin has resulted in an improvement of functional graft survival and has allowed a reduction in steroid dose and, in some cases, no steroids at all. It has permitted the first successful experimental transplantation of the heart and lungs in primate species by Reitz and colleagues and their results were applied directly to the clinic. It was largely due to the introduction of cyclosporin that the Washington Consensus Meeting on Liver Transplantation came to a favourable recommendation and the result has been the proliferation of units performing liver transplantation, approximately fifty in North America and another fifty in Europe, where previously there had been a handful. Having been involved in cyclosporin for organ grafting from the beginning, I have been able to witness these developments which have far exceeded my expectations once the nephrotoxicity of cyclosporin was demonstrated in man. It is fitting that Dr.

Keywords

T cell bone marrow cell cytokine drug kinetics metabolism pharmacokinetics research skin transplantation

Editors and affiliations

  • Angus W. Thomson
    • 1
  1. 1.Immunopathology Laboratory, Department of PathologyUniversity of AberdeenAberdeenScotland

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-009-0859-8
  • Copyright Information Springer Science+Business Media B.V. 1989
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-6874-1
  • Online ISBN 978-94-009-0859-8
  • About this book
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