Abstract
More than 500 recent-onset diabetics have been treated with cyclosporine A (CsA) in an attempt to induce remission of the disease. All published reports have shown a favourable effect but problems persist which still preclude large-scale use of this new clinical application of CsA. In this article we shall review the main features of the use of CsA in experimental and clinical diabetes mellitus.
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Laupacis, A., Gardell, C., Dupré, J-, Stiller, C R., Keown, P., Wallace, A. C. and Thibert, P. (1983) Cyclosporin prevents diabetes in BB Wistar rats. Lancet, 1, 10–12
Mori, Y., Suko, M., Odudaira, M., Matsuba, I., Tsuruoka, A., Sasaki, A., Yokoyama, M., Tanase, T., Shida, T., Nishimura, M., Terada, E. and Ykeda, Y. (1986) Preventive effects of cyclosporin on diabetes in NOD mice. Diabetohgia, 29, 244–247
Like, A. A., Dirodi, V., Thomas, S., Guberski, D. L. and Rossini, A. A. (1984) Prevention of diabetes mellitus in the BB/W rat with cyclosporin A. Am. J. Pathol., 117, 92–97
Boitard, C. and Bach, J. F. (1986) Experimental models of type I diabetes. Pathol. Immunopathol. Res., 5, 384–415
Stiller, C. R., Dupré, J., Gent, M., Jenner, M. R., Keown, P. A., Laupacis, A., Martell, R., Rodger, N. W., Granffenried, B. V. and Wole, B. M. J. (1984) Effects of cyclosporin immunosuppression in insulin-dependent diabetes mellitus of recent onset. Science, 223, 1362–1367
Assan, R., Feutren, G., Debray-Sachs, M., Quiniou-debrie, M. C., Laborie, C., Thomas, G., Chatenoud, L. and Bach, J. F. (1985) Metabolic and immunological effects of cyclosporin in recently diagnosed type I diabetes mellitus. Lancet, 1, 67–71
Feutren, G., Papoz, L., Assan, R., Vialettes, B., Karsenty, G., Vexiau, P., Du Rostu, H., Rodier, M., Sirmai, J., Lallemand, A. and Bach, J. F. (1986) Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Lancet, 1, 119–123
Canadian—European Diabetes Study Group (1988) Cyclosporin-induced remission of IDDM after early intervention: association of 1 year of cyclosporin treatment with enhanced insulin secretion. Diabetes, 37, 1574–1582
Bougnères, P. H., Carel, J. C., Castano, L., Boitard, C., Gardin, J. P., Landais, P., Hors, J., Mihatsch, M. J. and Paillard, M. (1988) Factors determining early remission of type 1 diabetes in children treated with cyclosporin A. N. Engl J. Med., 318, 663–670
Gotfredsen, G. F., Buschard, K. and Frandsen, E. K. (1985) Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals. Diabeiohgia, 28, 933–935
Shah, S. C., Malone, J. I. and Simpson, N. E. (1989) A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus. N. Engl J. Med., 320, 550–554
Wang, Y., McDuffie, M., Nomikos, I. N., Hao, L. and Lafferty, K. J. (1988) Effect of cyclosporine in immunologically mediated diabetes in nonobese diabetic mice. Transplantation, 46, 101S–106S (Suppl. 5).
Mountz, J. D., Smith, H. R., Wilder, R. L., Reeves, J. P. and Steinberg, A. D. (1987) CsA therapy in MRL-lp/lpr mice: amelioration of immunopathology despite autoantibody production. J. Immunol., 138, 157–163
Feutren, G., Querin, S., Noel, L. H., Chatenoud, L., Beaurain, G., Tron, F., Lesavre, P. and Bach, J. F. (1987) Effects of cyclosporine in severe systemic lupus. J. Pediatr., 111, 1063–168
Dupré, J., Stiller, C. R., Gent, M., Dormer, A., Von Graffenreid, B., Murphy, G., Heinrichs, D., Jeriner, M. R., Keown, P. A., Laupacis, A., Mahon, J., Martell, R., Rodger, N. W. and Wolfe, B. W. (1988) Effects of immunosuppression with cyclosporine in insulin-dependent diabetes mellitus of recent onset: the Canadian open study at 44 months. Transplant. Proc., 20, 184–192
Molvig, J., Mandrup-Poulson, T., Andersen, H. U., Spinas, G. A., Helqvist, S. and Munck, M. (1988) Ciclosporin immunotherapy in Type 1 (insulin-dependent) diabetes: importance of HLA-DR phenotype for the clinical and immunological response (abstract). In: Abstracts Meeting Immunomoduhtion in Autoimmune Disease, Paris, June 1988
Hors, J., Papoz, L., Eschwege, E., Vexiau, P., Geutren, G., Boitard, C. and Bach, J. F. (1988) HLA and responsiveness to cyclosporin A in treated IDD patients (abstract). In: Abstracts Meeting Immunomoduhtion in Autoimmune Disease, Paris, June 1988
Boitard, C., Feutren, G., Castano, L., Debray-Sachs, M., Assan, R., Hors, J. and Bach, J. F. (1987) The effect of cyclosporin A treatment on the production of antibody in insulin-dependent (type I) diabetic patients. J. Clin. Invest., 80, 1607–1612
Debray-Sachs, M., Sai, P., Feutren, G., Lang, F., Maugendre, D., Boitard, C., Hors, J. and Bach, J. F. (1988) Inhibition of insulin release in vitro mediated by mononuclear cells from cyclosporin A or placebo treated diabetic patients. Diabetes, 37, 873–877
Bach, J. F. (1988) Mechanisms of autoimmunity in insulin-dependent diabetes mellitus. Clin. Exp. Immunol., 72, 1–8
Chatenoud, L., Feutren, G., Nelson, D. L., Boitard, C., Charron, D. J. and Bach, J. F. (1988) T cell mediated immunity in insulin dependent diabetic patients: effect of cyclosporin. Diabetes (In press)
Caillat-Zucman, S., Chatenoud, L. and Bach, J. F. (1988) Differential in vitro and in vivo action of cyclosporin A on the induction of IL-2 receptor α and β chains. Clin. Exp. Immunol. (in press)
Chatenoud, L., Dugas, B., Damais, C. and Bach, J. F. (1988) In vivo cyclosporine A treatment inhibits spleen cell mitogen-fcriggered free (Ca2 +) increase. Transplant. Proc., 20, 170–172
Feutren, G. (1988) Functional consequences and risk factors of chronic cyclosporine nephrotoxicity in Type I diabetes trials. Transplant. Proc., 20, 356–366
Starzl, T. E., Porter, K. A., Iwatsuki, S., Rosenthal, J. T., Shaw, B. W. Jr., Atchinson, R. W., Nalesnik, M. A., Ho, M., Griffith, B. P., Hakala, T. R., Hardesty, R. L. and Jaffe, R. (1984) Reversibility of lymphomas and lympho-proliferative lesions developing under cyclosporin-steroid therapy. Lancet, 1, 583–587
Mahon, J. L., Gurun, H. C., Stobie, K., Gibson, C., Garcia, B., Dupré, J. and Stiller, C. R. (1988) The effect of bromocriptine and cyclosporine on spontaneous diabetes in BB rats. Transplant. Proc., 20, 197–200
Assan, R., Feutren, G. and Sirmai, J. (1988) Cyclosporine trials in diabetes: updated results of the French experience. Transplant. Proc., 20, 178–183
Shizuru, J. A., Taylor-Edwards, C., Banks, B. A., Gregory, A. K. and Fathman, C. G. (1988) Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes. Science, 240, 659–661
Chatenoud, L., Ferran, C., Reuter, A., Franchimont, P., Legendre, C., Kreis, H. and Bach, J. F. (1988) Clinical use of OKT3: the role of cytokine release and xenosensitization. J. Autoimmunity, 1, 631–640
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© 1989 Kluwer Academic Publishers
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Bach, JF. (1989). Cyclosporin A in insulin-dependent diabetes. In: Thomson, A.W. (eds) Cyclosporin. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0859-8_9
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DOI: https://doi.org/10.1007/978-94-009-0859-8_9
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6874-1
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