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Cyclosporin A and intraocular inflammatory disease

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Cyclosporin

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Abstract

Although the benefits of cyclosporin A (CsA) therapy in various transplantation procedures had been clearly recognized for some time, the introduction of CsA to ophthalmology did not occur until 1980 when the drug was used on an experimental model of autoimmune ocular inflammation, namely experimental autoimmune uveoretinitis (EAU)1. That it was not first used for transplantation management in ophthalmology was in part due to the low rate of corneal graft rejection compared to renal or cardiac graft rejection and, if rejection did occur, it was often controlled satisfactorily with topical steroids provided it was diagnosed sufficiently early. However, the early use of CsA in EAU also reflected a continuing major clinical problem in ophthalmology, namely endogenous posterior uveitis. Posterior uveitis, a significant cause of blindness in the USA and other countries2, is probably autoimmune in nature, at least in some of its clinical forms, and is often refractory to treatment even with systemic steroids. Some special forms of uveitis such as Behcet’s disease are highly prevalent in certain geographical regions such as the Middle East, Turkey and Japan, and represent a considerable morbidity in these countries.

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Authors
  1. John V. Forrester
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  2. Janet Liversidge
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  3. Hamish M. Towler
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Editors and Affiliations

  1. Immunopathology Laboratory, Department of Pathology, University of Aberdeen, Foresterhill, Aberdeen, AB9 2ZD, Scotland

    Angus W. Thomson BSc(Hons), MSc, PhD, DSc, MRCPath, FIBiol (Reader in Immunology) (Reader in Immunology)

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© 1989 Kluwer Academic Publishers

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Forrester, J.V., Liversidge, J., Towler, H.M. (1989). Cyclosporin A and intraocular inflammatory disease. In: Thomson, A.W. (eds) Cyclosporin. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0859-8_8

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  • DOI: https://doi.org/10.1007/978-94-009-0859-8_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6874-1

  • Online ISBN: 978-94-009-0859-8

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