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Influence of CsA on humoral immunity and on B lymphocyte activation

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Cyclosporin

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Abstract

CsA is a hydrophobic cyclic undecapeptïde of fungal origin with potent specific immunosuppressive effects in vivo and in vitro. Since its discovery by Borel and his group in 19761, CsA has proved an effective and valuable agent for suppression of allograft rejection in animals and has found widespread clinical acceptance2,3. CsA is highly specific for lymphocytes and this property suggested that these cells possess some unique features of growth control which might be unravelled through an understanding of the CsA mode of action. Consequently, many laboratories have investigated the effect of this drug on lymphocyte stimulation by antigens or by polyclonal mitogenic or non-mitogenic B cell activators.

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Authors
  1. Iris Motta
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  2. Paolo Truffa-Bachi
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Editors and Affiliations

  1. Immunopathology Laboratory, Department of Pathology, University of Aberdeen, Foresterhill, Aberdeen, AB9 2ZD, Scotland

    Angus W. Thomson BSc(Hons), MSc, PhD, DSc, MRCPath, FIBiol (Reader in Immunology) (Reader in Immunology)

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Motta, I., Truffa-Bachi, P. (1989). Influence of CsA on humoral immunity and on B lymphocyte activation. In: Thomson, A.W. (eds) Cyclosporin. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0859-8_3

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  • DOI: https://doi.org/10.1007/978-94-009-0859-8_3

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