Overview
- Editors:
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Eugenio E. Müller
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Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
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Daniela Cocchi
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Pharmaco-biological Institute, University of Bari, Bari, Italy
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Vittorio Locatelli
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Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
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Table of contents (28 papers)
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Plenary Lecture
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- K. W. Kelley, S. Arkins, Y. M. Li, A. Biragyn
Pages 173-192
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Pubertal Development
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Front Matter
Pages 193-193
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- S. R. Ojeda, G. A. Dissen, Y. J. Ma, M.-P. Junier, W. L. Dees
Pages 195-205
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- M. L. Aubert, N. M. Gruaz, D. D. Pierroz, V. d’Allèves, A. C. Aebi, N. Chiarello et al.
Pages 206-217
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- G. Theintz, T. Torresani, P. Bishof, U. Weiss, P. C. Sizonenko
Pages 218-228
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- A. D. Rogol, P. M. Martha Jr., N. Mauras, F. Nieves-Rivera, M. Bishop, R. M. Blizzard
Pages 229-243
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Plenary Lecture
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Front Matter
Pages 245-245
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- L. E. Underwood, D. R. Clemmons, S. Kupfer, J. L. Walker, J. J. Van Wyk
Pages 247-262
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Adulthood and Senescence
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Front Matter
Pages 263-263
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- A. R. Hoffman, G. Pyka, S. A. Lieberman, G. P. Ceda, R. Marcus
Pages 265-274
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- E. Ghigo, E. Arvat, S. Goffi, J. Bellone, M. Nicolosi, M. Procopio et al.
Pages 275-287
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- A. J. Weissberger, R. C. Cuneo, F. Salomon, G. A. McGauley, C. Lowy, P. H. Sönksen
Pages 288-301
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- R. Marcus, L. Holloway, G. Butterfield
Pages 302-306
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- T. R. Ziegler, D. W. Wilmore
Pages 312-328
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- S. W. J. Lamberts, A. Binnerts
Pages 329-335
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Back Matter
Pages 337-343
About this book
The various congresses on growth hormone (GH) which have been held in Milan since 1967, the Milan Congresses, have witnessed over 25 years the tremendous expansion of a research field that was based initially upon the scarce knowledge of the biological properties of a protein. GH, whose chemical structure had just been identified and a radioimmunoassay developed for its measurement in blood, became in the following years a major area of biological research. The boundaries have since become blurred, as the research area has extended to the physiology and pathology of growth, puberty and reproduction, and the control of metabolism during the whole lifespan. Since the last GH Congress held in 1987, GH studies using the molecular biological approach have resulted in the puri fication, cloning and expression of the human GH (hGH) recep tor and binding protein, in new and exciting information on the insulin-like growth factors (IGF) and their paracrine and autocrine roles, and in the awareness that a panoply of binding proteins are present in the extracellular fluids and can, possibly, modulate IGF-receptor interactions and, thus, IGF actions. Finally, the availability of large amounts of biosynthetic hGH, besides allow ing more extensive clinical use in states of GH deficiency and extrasomatotrophic pathologies, has permitted disclosure of im portant metabolic effects of hGH during adulthood and, perhaps, aging and in many protein catabolic states.