Growth Hormone, Insulin-like Growth Factor I, and Immune Function

  • K. W. Kelley
  • S. Arkins
  • Y. M. Li
  • A. Biragyn
Conference paper

Abstract

It is now clear that growth hormone affects the immune system of many animals, as reviewed by us (Kelley 1989, 1991 Kelley et al. 1992 Arkins and Kelley 1993) and others (Weigent and Blalock 1990 Berczi and Nagy 1991 Gala 1991). Interest in the immunological role of growth hormone, and the closely related molecule, prolactin, has increased substantially since cloning of their receptors revealed that they are both members of a new superfamily of cytokine receptors which includes IL-2, IL-3, IL-6, IL-7, granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin (Bazan 1990 Cosman et al. 1990). The highly conserved nature of these cytokine and hormone receptors suggests that the somatolactogenic hormones are involved in the growth and differentiation of both lymphoid and myeloid cells. Emerging evidence from the immune and nervous systems (Rodriguez-Tarduchy et al. 1992; Barres et al. 1992) indicates that many of these effects may be mediated through insulin-like growth factor I (IGF-I). The purpose of this article is to summarize and integrate data published within the past 2 years which have addressed the possibility that somatolactogens and somatomedins are involved in regulation of the immune response. Readers are directed to earlier reviews (see above) for a more complete discussion of experimental work published before 1990.

Keywords

Placebo Lymphoma Oncol Interferon Glucocorticoid 

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References

  1. Adams DO, Hamilton TA (1987) Molecular transductional mechanisms by which JFNγ and other signals regulate macrophage development. Immunol Rev 97:5–27.PubMedCrossRefGoogle Scholar
  2. Arkins JF (1992) Characterization and regulation of insuli-like growth factor I mRNA transcripts in myeloid cells. PhD Thesis, University of Illinois.Google Scholar
  3. Arkins S, Kelley KW (1993) Somatolactogens, somatomedins and immunity. J Dairy Sci 76:2437–2450.PubMedCrossRefGoogle Scholar
  4. Astaldi A Jr, Yalcin B, Meardi G, Burgio GR, Merolla R, Astaldi G (1973) Effect of growth hormone on lymphocyte transformation in cell culture. Blut 26:74–81.PubMedCrossRefGoogle Scholar
  5. Barres BA, Hart IK, Coles HSR, Burae JF, Voyvodic JT, Richardson WD, Raff MC (1992) Cell death and control of cell survival in the oligodendrocyte lineage. Cell 70:31–46.PubMedCrossRefGoogle Scholar
  6. Baxter JB, Blalock JE, Weigent DA (1991) Characterization of immunoreactive insulin-like growth factor-I from leukocytes and its regulation by growth hormone. Endocrinology 129:1727–1734.PubMedCrossRefGoogle Scholar
  7. Bazan JF (1990) Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 87:6934–6938.PubMedCrossRefGoogle Scholar
  8. Berczi I, Nagy E (1991) Effects of hypophysectomy on immune function. In: Ader R, Felten DL, Cohen N (eds) Psychoneuroimmunology, 2nd edn. Academic, New york, pp 339–375.Google Scholar
  9. Berczi I, Nagy E, de Toledo SM, Matusik RJ, Friesen HG (1991) Piuitary hormones regulate c-myc and DNA synthesis in lymphoid tissue. J Immunol 146:2201–2206.PubMedGoogle Scholar
  10. Beraton E, Bryant H, Holaday J, Dave J (1992) Prolactin and prolactin secretagogues reverse immunosuppression in mice treated with cysteamine, glucocorticoids, or cyclosporin-A. Brain Behav Immun 6:394–408.CrossRefGoogle Scholar
  11. Binz K, Joller P, Froesch P, Binz H, Zapf J, Froesch ER (1990) Repopulation of the atrophied thymus in diabetic rats by insulin-like growth factor I. Proc Natl Acad Sci USA 87:3690–3694.PubMedCrossRefGoogle Scholar
  12. Bozzola M, Cisternino M, Valtorta A, Moretta A, Biscaldi I, Maghnie M, De Amici M, Schimpff RM (1989) Effect of biosynthetic methionyl growth hormone (GH) therapy on the immune function in GH-defieient children. Horm Res 31:153–156.PubMedCrossRefGoogle Scholar
  13. Bozzola M, Valtorta A, Moretta A, Cisternino M, Biscaldi I, Schimpff RM (1990) In vitro and in vivo effect of growth hormone on cytotoxic activity. J Pediatr 117:596–599.PubMedCrossRefGoogle Scholar
  14. Chen Y, Johnson AG (1993) In vivo activation of macrophages by prolactin from young and aging mice. Int J Immunopharmacol 15:39–45.PubMedCrossRefGoogle Scholar
  15. Claustres M, Chatelain P, Sultan C (1987) Insulin-like growth factor I stimulates human erythroid colony formation. J Clin Endocrinol Metab 65:78–82.PubMedCrossRefGoogle Scholar
  16. Cosman D, Layman SD, Idzerda RL, Beckmann MP, Park LS, Goodwin RG, March CJ (1990) A new cytokine receptor superfamily. Trends Biochem Sci 15:265–270.PubMedCrossRefGoogle Scholar
  17. Cross RJ, Bryson JS, Roszman TL (1992) Immunologie disparity in the hypopituitary dwarf mouse. J Immunol 148:1347–1352.PubMedGoogle Scholar
  18. Daughaday WH (1990) The possible autocrine/paracrine and endocrine roles of insulin-like growth factors of human tumors (editorial). Endocrinology 127:1–4.PubMedCrossRefGoogle Scholar
  19. Davila DR, Brief S, Simon J, Hammer RE, Brinster RL, Kelley KW (1987) Role of growth hormone in regulating T-dependent immune events in aged, nude and transgenic rodents. J Neurosci Res 18:108–116.PubMedCrossRefGoogle Scholar
  20. Donskoy E, Goldschneider I (1992) Thymocytopoiesis is maintained by blood-borne precursors throughout postnatal life: A study in parabiotic mice. J Immunol 148:1604–1612.PubMedGoogle Scholar
  21. Dubiski S, Ponnappan U, Cinader B (1989) Strain polymorphism in progression of aging: changes in CD4, CD8 bearing subpopulations. Immunol Lett 23:1–8.PubMedCrossRefGoogle Scholar
  22. Edwards CK III, Ghiasuddin SM, Schepper JM, Yunger LM, Kelley KW (1988) A newly defined property of somatotropin: priming of macrophages for production of Superoxide anion. Science 239:769–771.PubMedCrossRefGoogle Scholar
  23. Edwards CK III, Lorence RM, Dunham DM, Arkins S, Yunger LM, Greager JA, Walter RJ, Dantzer R, Kelley KW (1991a) Hypophysectomy inhibits the synthesis of tumor necrosis factor α by rat macrophages: partial restoration by exogenous growth hormone or interferon γ. Endocrinology 128:989–996.PubMedCrossRefGoogle Scholar
  24. Edwards CK III, Yunger LM, Lorence RM, Dantzer R, Kelley KW (1991b) The pituitary gland is required for protection against lethal effects of Salmonella typhimurium. Proc Natl Acad Sci USA 88:2274–2277.PubMedCrossRefGoogle Scholar
  25. Edwards CK III, Arkins S, yunger LM, Blum A, Dantzer R, Kelley KW (1992a) The maerophage-activat properties of growth honnone. Cell Mol Neurobiol 12:499–510.PubMedCrossRefGoogle Scholar
  26. Edwards CK III, Ghiasuddin SM, yunger LM, Lorence RM, Arkins S, Dantzer R, Kelley KW (1992b) In vivo administration of recombinant growth hormone or interferon-γ activates macrophages: enhanced resistance to experimental Salmonella typhimurium infection is correlated with the generation of reactive oxygen intermediates. Infect Immun 60:2514–2521.PubMedGoogle Scholar
  27. Estrov Z, Meir R, Barak Y, Zaizov R, Zadik Z (1991) Human growth hormone and insulin-like growth factor I enhance the proliferation of human leukemic blasts. J Clin Oncol 9:394–399.PubMedGoogle Scholar
  28. Fu YK, Arkins S, Wang BS, Kelley KW (1991) A novel role of growth hormone and insulin-like growth factor-I: priming neutrophils for Superoxide anion secretion. J Immunol 146: 1602–1608.PubMedGoogle Scholar
  29. Fu YK, Arkins S, Fuh G, Cunningham BC, Wells JA, Fong S, Cronin MJ, Dantzer R, Kelley KW (1992) Growth hormone augments Superoxide anion secretion of human neutrophils by binding to the prolactin receptor. J Clin Invest 89:451–457.PubMedCrossRefGoogle Scholar
  30. Gala RR (1991) Prolactin and growth hormone in the regulation of the immune system. Proc Soc Exp Biol Med 198:513–527.PubMedGoogle Scholar
  31. Geffner ME, Bersch N, Lippe BM, Rosenfeld RG, Hintz RL, Golde DW (1990) Growth hormone mediates the growth of T-lymphoblast cell Unes via locally generated insulin-like growth factor-I. J Clin Endocrinol Metab 71:464–469.PubMedCrossRefGoogle Scholar
  32. Geffner ME, Bersch N, Golde DW (1992) Insulin and IGF-I stimulate normal and virally-transformed T-lymphocyte cell growth in vitro. Brain Behav Immun 6:377–386.PubMedCrossRefGoogle Scholar
  33. Gjerset RA, Yeatgin J, Volkman SK, Vila V, Arya J, Haas M (1990) Insulin-like growth factor-I supports proliferation of autocrine thymic lymphoma cells with a pre-T cell phenotype. J Immunol 145:3497–3501.PubMedGoogle Scholar
  34. Goff BL, Roth JA, Arp LH, Incefy GS (1987) Growth hormone treatment stimulates thymulin production in aged dogs. Clin Exp Immunol 68:580–587.PubMedGoogle Scholar
  35. Goya RG, Gagnerault MC, Leite de Moraes MC, Savino W, Dardenne M (1992) In vivo effects of growth hormone on thymus function in aging mice. Brain Beh Immun 6:341–354.CrossRefGoogle Scholar
  36. Groenwegen PP, McBride BW, Burton JH, Elsasser TH (1990) Bioactivity of milk from bST-treated cows. J Nutr 120:514–520.Google Scholar
  37. Guler HP, Zapf J, Scheiwiller E, Froesch ER (1988) Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats. Proc Natl Acad Sci USA 85:4889–4893.PubMedCrossRefGoogle Scholar
  38. Intebi AD, Palacios MF, Sen L, Diez RA (1992) Defective B-cell differentiation under PWM induction in acromegaly. Prog Neuroendocrinimmunol 5:62–69.Google Scholar
  39. Johnson EW, Jones LA, Kozak RW (1992) Expression and function of insulin-like growth factor receptors on anti-CD3-activated human T lymphocytes. J Immunol 148:63–71.PubMedGoogle Scholar
  40. Kelley KW (1989) Growth hormone, lymphocytes and macrophages. Biochem Pharmacol 38:705–713.PubMedCrossRefGoogle Scholar
  41. Kelley KW (1991) Growth hormone in immunobiology. In: Ader R, Felten DL, Cohen N (eds) Psychoneuroimmunology, 2nd edn. Academic, New york, pp 377–402.Google Scholar
  42. Kelley KW, Dantzer R (1991) Growth hormone and prolactin as natural antagonists of glucocorticoids in immunoregulation. In: Plotnikoff N, Murgo A, Faith R, Wybran J (eds) Stress and immunity. CRC Press, Boca Raton, pp 433–452.Google Scholar
  43. Kelley KW, Brief S, Westly HJ, Novakofski J, Bechtel PJ, Simon J, Walker EB (1986) GH3 pituitary adenoma implants can reverse thymic aging. Proc Natl Acad Sci USA 83:5663–5667.PubMedCrossRefGoogle Scholar
  44. Kelley KW, Arkins S, Li YM (1992) Growth hormone, prolactin and insulin-like growth factor: new jobs for old players. Brain Behav Immun 6:317–326.PubMedCrossRefGoogle Scholar
  45. Khansari DN, Gustad T (1991) Effects of long-term, low-dose growth hormone therapy on immune function and life expectancy of mice. Mech Ageing Dev 57:87–100.PubMedCrossRefGoogle Scholar
  46. Kiess W, Malozowski S, Gelato M, Butenand O, Doerr H, Crisp B, Eisl E, Maluish A, Belohradsky BH (1988) Lymphocyte subset distribution and natural killer activity in growth hormone deficiency before and during short-term treatment with growth hormone releasing hormone. Clin Immunol Immunopathol 48:85–94.PubMedCrossRefGoogle Scholar
  47. Knyszynski A, Adler-Kunin S, Globerson A (1992) Effects of growth hormone on thymocyte development from progenitor cells in the bone marrow. Brain Behav Immun 6:327–340.PubMedCrossRefGoogle Scholar
  48. Kurtz A, Zapf J, Eckardt KU, Clemons G, Froesch ER, Bauer C (1988) Insulin-like growth factor I stimulates erythropoiesis in hypophysectomized rats. Proc Natl Acad Sci USA 85:7825–7829.PubMedCrossRefGoogle Scholar
  49. Laurence J, Grimison B, Gonenne A (1992) Effect of recombinant human growth hormone on acute and chronic human immunodeficiency virus infection in vitro. Blood 79:467–472.PubMedGoogle Scholar
  50. Lee PDK, Rosenfeld RG, Hintz RL, Smith SD (1986) Characterization of insulin, insulin-like growth factors I and II, and growth hormone receptors on human leukemic lymphoblasts. J Clin Endocrinol Metab 62:28–35.PubMedCrossRefGoogle Scholar
  51. Li YM, Brunke DL, Dantzer R, Kelley KW (1992) Pituitary epithelial cell implants reverse the accumulation of CD4-CD8- lymphocytes in thymus glands of aged rats. Endocrinology 130:2703–2709.PubMedCrossRefGoogle Scholar
  52. Lynch SE, Colvin RB, Antoniades HN (1989) Growth factors and wound healing: single and synergistic effects on partial thickness porcine skin wounds. J Clin Invest 84:640–646.PubMedCrossRefGoogle Scholar
  53. Matera L, Cesano A, Muccioli G, Veglia F (1990) Modulatory effect of prolactin on the DNA synthesis rate and NK activity of large granular lymphocytes. Int J Neurosci 51:265–267.PubMedCrossRefGoogle Scholar
  54. Matera L, Cesano A, Bellone G, Oberholtzer E (1992) Modulatory effect of prolactin on the resting and mitogen induced activity of T, B and NK lymphocytes. Brain Behav Immun 6:409–417.PubMedCrossRefGoogle Scholar
  55. Matsuura M, Kikkawa Y, Kitagawa T, Tanaka S (1989) Modulation of immunological abnormalities of growth hormone-deficient children by growth hormone treatment. Acta Paediatr Jpn 31:53–57.PubMedGoogle Scholar
  56. McCormick KR, Haar JL, Tauberberger JK, Krieg RJ (1991) A murine model for regeneration of the sensecent thymus using growth hormone therapy. Aging Immunol Infect Dis 3:19–26.Google Scholar
  57. Merchav S, Tatarsky I, Hochberg Z (1988a) Enhancement of human granulopoiesis in vitro by biosynthetic insulin-like growth factor-I/somatomedin C and human growth hormone. J Clin Invest 81:791–797.PubMedCrossRefGoogle Scholar
  58. Merchav, S, Tatarsky I, Hochberg Z (1988b) Enhancement of erythropoiesis in vitro by human growth hormone is mediated by insulin-like growth factor I. Br J Haematol 70:267–271.PubMedCrossRefGoogle Scholar
  59. Merimee TJ, Grant MB, Broder CM, Cavalli-Sforza LL (1989) Insulin-like growth factor secretion by human B lymphocytes: a comparison of cells from normal and pygmy subjects. J Clin Endocrinol Metab 69:978–984.PubMedCrossRefGoogle Scholar
  60. Monroe WE, Roth JA, Grier RL, Arp LH, Naylor PH (1987) Effects of growth hormone on the adult canine thymus. Thymus 9:173–187.PubMedGoogle Scholar
  61. Murphy WJ, Durum SK, Anver M, Longo DL (1992a) Recombinant human growth hormone promotes human lymphocyte engraftment in immunodeficient mice and results in the increased occurence of human Epstein Barr virus-induced B-cell lymphoma. Brain Behav Immun 6:355–364.PubMedCrossRefGoogle Scholar
  62. Murphy WJ, Durum SK, Anver MR, Longo DL (1992b) Immunologic and hematologic effects of neuroendocrine hormones: studies on DW/J dwarf mice. J Immunol 148:3799–3805.PubMedGoogle Scholar
  63. Murphy WJ, Durum SK, Longo DL (1992c) Human growth hormone promotes engraftment of murine or human T cells in SCID mice. Proc Natl Acad Sci USA 89:4481–4485.PubMedCrossRefGoogle Scholar
  64. Nagaoka I, Trapnell BC, Crystal RG (1990) Regulation of insulin-like growth factor I gene expression in the human macrophage-like cell line U937. J Clin Invest 85:448–455.PubMedCrossRefGoogle Scholar
  65. Nagy E, Berczi I (1991) Hypophysectomized rats depend on residual prolactin for survival. Endocrinology 128:2776–2784.PubMedCrossRefGoogle Scholar
  66. Pahlman S, Meyerson G, Lindgren E, Schalling M, Johansson I (1991) Insulin-like growth factor I shifts from promoting cell division to potentiating maturation during neuronal differentiation. Proc Natl Acad Sci USA 88:9994–9998.PubMedCrossRefGoogle Scholar
  67. Pepe MG, Ginztion NH, Lee PDK, Hintz RL, Greenberg PL (1987) Receptor binding and mitogenic effects of insulin and insulin-like growth factors I and II for human myeloid leukemia cells. J Cell Physiol 133:219–227.PubMedCrossRefGoogle Scholar
  68. Pellegrini I, Lebrun JJ, Ali S, Kelly PA (1992) Expression of prolactin and its receptor in human lymphoid cells. Mol Endocrinol 6:1023–1031.PubMedCrossRefGoogle Scholar
  69. Petersen BH, Rapaport R, Henry DP, Huseman C, Moore WV (1990) Effect of treatment with biosynthetic human growth hormone (GH) on peripheral blood lymphocyte populations and function in growth hormone-deficient children. J Clin Endocrinol Metab 70:1756–1760.PubMedCrossRefGoogle Scholar
  70. Rappolee DA, Mark D, Banda MJ, Werb Z (1988) Wound macrophages expresss TGF-a and other growth factors in vivo: analysis by mRNA phenotyping. Science 241:708–712.PubMedCrossRefGoogle Scholar
  71. Rodriguez-Tarduehy G, Collins MKL, Garcia I, Lopez-Rivas A (1992) Insulin-like growth factor I inhibits apoptosis in IL-3 dependent hemopoietic cells. J Immunol 149:535–540.Google Scholar
  72. Rom WN, Basset P, Fells GA, Nukiwa T, Trapnell BC, Crystal RG (1988) Alveolar macrophages release an insulin-like growth factor I type molecule. J Clin Invest 82:1685–1693.PubMedCrossRefGoogle Scholar
  73. Rotrosen D, Yeung CL, Leto TL, Malech HL, Kwong CH (1992) Cytochrome b558: the flavinbinding component of the phagocyte NADPH oxidase. Science 256:1459–1462.PubMedCrossRefGoogle Scholar
  74. Sabharwal P, Glaser R, Lafuse W, Varma S, Liu Q, Arkins S, Kooijman R, Kutz L, Kelley KW, Malarkey WB (1992a) Prolactin synthesized and secreted by human peripheral blood mononuclear cells: an autocrine growth factor for lymphoproliferation. Proc Natl Acad Sci USA 89:7713–7716.PubMedCrossRefGoogle Scholar
  75. Sabharwal P, Zwilling B, Glaser R, Malarkey WB (1992b) Cellular immunity in patients with acromegaly and prolactinomas. Prog Neuroendocrinimmunol 5:120–125.Google Scholar
  76. Scheven BAA, Hamilton NJ (1991) Stimulation of macrophage growth and multinucleated cell formation in rate bone marrow cultures by insulin-like growth factor I. Biochem Biophys Res Commun 174:647–653.PubMedCrossRefGoogle Scholar
  77. Shimatsu A, Rotwein P (1987) Mosaic evolution of the rat insulin-like growth factors. Organization, sequence and expression of the rat insulin-like growth factor I gene. J Biol Chem 262:7894–7900.PubMedGoogle Scholar
  78. Sinclair J, McClain D, Taetle R (1988) Effects of insulin and insulin-like growth factor I on growth of human leukemia cells in serum-free and protein-free medium. Blood 72:66–72.PubMedGoogle Scholar
  79. Smith SD, McFall P, Morgan R, Link M, Hecht F, Cleary M, Sklar J (1989) Long-term growth of malignant thymocytes in vitro. Blood 73:2182–2187.PubMedGoogle Scholar
  80. Stahnke N, Zeisel HJ (1989) Growth hormone therapy and leukaemia. Eur J Pediatr 148: 591–596.PubMedCrossRefGoogle Scholar
  81. Steenfos HH, Jansson JO (1992) Growth hormone stimulates granulation tissue formation and insulin-like growth factor-I gene expression in wound chambers in the rats. J Endocrinol 132:293–298.PubMedCrossRefGoogle Scholar
  82. Stephenson JR, Lee JM, Bailey N, Shepherd AG, Melling J (1991) Adjuvant effect of human growth hormone with an inactivated flavivirus vaccine. J Infect Dis 164:188–191.PubMedCrossRefGoogle Scholar
  83. Stuart CA, Meehan RT, Neale RS, Cintron NM, Furlanetto RW (1991) Insulin-like growth factor-I binds selectively to human peripheral blood monocytes and B lymphocytes. J Clin Endocrinol Metab 72:1117–1122.PubMedCrossRefGoogle Scholar
  84. Tapson VF, Boni-Schnetzler M, Pilch PF, Center DM, Berman JS (1988) Structural and functional characterization of the human T lymphocyte receptor for insulin-like growth factor I in vitro. J Clin Invest 82:950–957.PubMedCrossRefGoogle Scholar
  85. Timsit J, Savino W, Safieh B, Chanson P, Gagnerault MC, Bach JF, Dardenne M (1992) Growth hormone and insulin-like growth factor-I stimulate hormonal function and proliferation of thymic epithelial cells. J Clin Endocrinol Metab 75:183–188.PubMedCrossRefGoogle Scholar
  86. Torosian MH, Donoway RB (1991) Growth hormone inhibits tumor metastasis. Cancer 67:2280–2283.PubMedCrossRefGoogle Scholar
  87. Unanue ER, Allen PM (1987) The basis for the immunoregulatory role of macrophages and other accessory cells. Science 236:551–557.PubMedCrossRefGoogle Scholar
  88. Weigent DA, Blalock JE (1990) Growth hormone and the immune system. Prog Neuroendo-crinimmunol 3:231–241.Google Scholar
  89. Weigent DA, Blalock JE (1991) The production of growth hormone by subpopulations of rat mononuclear leukocytes. Cell Immunol 135:55–65.PubMedCrossRefGoogle Scholar
  90. Weigent DA, Blalock JE, LeBoeuf RD (1991) An antisense oligodeoxynucleotide to growth hormone messenger ribonucleic acid inhibits lymphocyte proliferation. Endocrinology 128:2053–2057.PubMedCrossRefGoogle Scholar
  91. Weigent DA, Baxter JB, Blalock JE (1992) The production of growth hormone and insulin-like growth factor-I by the same subpopulation of rat mononuclear leukocytes. Brain Behav and immun 6:365–376.CrossRefGoogle Scholar
  92. Werner H, Woloschak M, Adamo M, Shen-Orr Z, Roberts CT Jr, LeRoith D (1989) Developmental regulation of the rat insulin-like growth factor I receptor gene. Proc Natl Acad Sci USA 86:7451–7455.PubMedCrossRefGoogle Scholar
  93. Werther GA, Haynes K, Johnson GR (1990) Insulin-like growth factors promote DNA synthesis and support cell viability in fetal hemopoietic tissue by paracrine mechanisms. Growth Factors 3:171–179.PubMedCrossRefGoogle Scholar
  94. Wiedermann CJ (1993) Recombinant human growth hormone stimulates monocyte chemotaxis and deactivates monocyte migratory responses to other peptide chemoattractants. Blood (in press).Google Scholar
  95. Wiedermann CJ, Niedermuhlbichler M, Beimpold H, Braunsteiner H (1991a) In vitro activation of neutrophils of the aged by recombinant human growth hormone. J Infect Dis 164: 1017–1020.PubMedCrossRefGoogle Scholar
  96. Wiedermann CJ, Niedermuhlbichler M, Geissler D, Beimpold H, Braunsteiner H (1991b) Priming of normal human neutrophils by recombinant human growth hormone. Br J Haematol 78:19–22.PubMedCrossRefGoogle Scholar
  97. Wiedermann CJ, Reinisch N, Kahler C, Geisen F, Zilian U, Herold M, Braunsteiner H (1992) In vivo activation of circulating monocytes by exogenous growth hormone in man. Brain Behav Immun 6:387–393.PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • K. W. Kelley
  • S. Arkins
  • Y. M. Li
  • A. Biragyn

There are no affiliations available

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