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Regulation of Female Sexual Development by Neurotrophic Factors

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Growth Hormone and Somatomedins during Lifespan

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Abstract

The hypothalamic-pituitary-gonadal axis is the anatomical and functional core of the neuroendocrine process that controls sexual development. In females, the attainment of reproductive maturity is signaled by occurrence of the first ovulation. Nevertheless, the initiating events take place in the brain, where they result in synchronous activation of the luteinizing hormone-releasing hormone (LHRH) neuronal network (for a review see Ojeda 1991). The resulting increase in LHRH output then stimulates the secretion of adenohypophyseal gonadotropic hormones, which in turn, stimulate ovarian hormone secretion and facilitate development of the gland.

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Authors
  1. S. R. Ojeda
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  2. G. A. Dissen
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  3. Y. J. Ma
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  4. M.-P. Junier
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  5. W. L. Dees
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, 20129, Milan, Italy

    Eugenio E. Müller (Professor of Pharmacology) & Vittorio Locatelli (Associate Professor of Pharmacology) (Professor of Pharmacology) &  (Associate Professor of Pharmacology)

  2. Pharmaco-biological Institute, University of Bari, 70125, Bari, Italy

    Daniela Cocchi (Professor of Pharmacology) (Professor of Pharmacology)

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© 1993 Springer-Verlag Berlin Heidelberg

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Ojeda, S.R., Dissen, G.A., Ma, Y.J., Junier, MP., Dees, W.L. (1993). Regulation of Female Sexual Development by Neurotrophic Factors. In: Müller, E.E., Cocchi, D., Locatelli, V. (eds) Growth Hormone and Somatomedins during Lifespan. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78217-6_17

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  • DOI: https://doi.org/10.1007/978-3-642-78217-6_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78219-0

  • Online ISBN: 978-3-642-78217-6

  • eBook Packages: Springer Book Archive

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