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Growth Hormone and Somatomedins during Lifespan

  • Eugenio E. Müller
  • Daniela Cocchi
  • Vittorio Locatelli

Table of contents

  1. Front Matter
    Pages I-XV
  2. Growth Hormone

    1. Front Matter
      Pages 1-1
    2. V. Locatelli, S. G. Cella, D. Cocchi, V. Gennaro De Colonna, E. Giavini, M. Parenti et al.
      Pages 3-18
    3. M. J. Waters, S. W. Rowlinson, K. S. Gobius, P. E. Lobie, J. Garcia-Aragon, G. E. Muscat et al.
      Pages 26-43
    4. G. Norstedt, C. Carter-Su, S. Enerbäck, B. Enberg, G. Bjursell, S. Francis et al.
      Pages 44-51
  3. Somatomedins

    1. Front Matter
      Pages 53-53
    2. M. L. Adamo, D. LeRoith, C. T. Roberts Jr.
      Pages 55-64
    3. J. Isgaard, A. Nilsson, C. Ohlsson, A. Lindahl, H. Wåhlander, P. Friberg et al.
      Pages 65-71
    4. P. Nissley, W. Lopaczynski
      Pages 72-87
    5. J. M. Ketelslegers, J. P. Thissen, D. Maiter, T. Fliesen, T. Mauerhoff, S. Triest et al.
      Pages 88-99
  4. Fetal and Neonatal Growth

    1. Front Matter
      Pages 129-129
    2. V. R. Sara, C. Ayer-Le Lievre, C. Carlson-Skwirut, K. Drakenberg, M. B. Giacobini, L. Olson et al.
      Pages 141-146
    3. P. D. Gluckman, J. E. Harding, M. H. Oliver, L. Liu, G. R. Ambler, M. Klempt et al.
      Pages 147-160
  5. Plenary Lecture

    1. Front Matter
      Pages 171-171

About these proceedings

Introduction

The various congresses on growth hormone (GH) which have been held in Milan since 1967, the Milan Congresses, have witnessed over 25 years the tremendous expansion of a research field that was based initially upon the scarce knowledge of the biological properties of a protein. GH, whose chemical structure had just been identified and a radioimmunoassay developed for its measurement in blood, became in the following years a major area of biological research. The boundaries have since become blurred, as the research area has extended to the physiology and pathology of growth, puberty and reproduction, and the control of metabolism during the whole lifespan. Since the last GH Congress held in 1987, GH studies using the molecular biological approach have resulted in the puri­ fication, cloning and expression of the human GH (hGH) recep­ tor and binding protein, in new and exciting information on the insulin-like growth factors (IGF) and their paracrine and autocrine roles, and in the awareness that a panoply of binding proteins are present in the extracellular fluids and can, possibly, modulate IGF-receptor interactions and, thus, IGF actions. Finally, the availability of large amounts of biosynthetic hGH, besides allow­ ing more extensive clinical use in states of GH deficiency and extrasomatotrophic pathologies, has permitted disclosure of im­ portant metabolic effects of hGH during adulthood and, perhaps, aging and in many protein catabolic states.

Keywords

G proteins Wachstumshormon biosynthesis growth growth factor growth hormone hormone hormone therapy insulin-like metabolism nutrition protein puberty somatomedins steroid

Editors and affiliations

  • Eugenio E. Müller
    • 1
  • Daniela Cocchi
    • 2
  • Vittorio Locatelli
    • 1
  1. 1.Department of Pharmacology, School of MedicineUniversity of MilanMilanItaly
  2. 2.Pharmaco-biological InstituteUniversity of BariBariItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-78217-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1993
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-78219-0
  • Online ISBN 978-3-642-78217-6
  • Buy this book on publisher's site
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Biotechnology
Pharma