• Irvine H. Page
  • F. Merlin Bumpus

Table of contents

  1. Front Matter
    Pages N1-XIX
  2. Leonard T. Skeggs, Frederic E. Dorer, Joseph R. Kahn, Kenneth E. Lentz, Melvin Levine
    Pages 1-16
  3. J. R. Vane
    Pages 17-40
  4. J. W. Ryan
    Pages 81-110
  5. J. G. Ledingham, W. P. Leary
    Pages 111-125
  6. M. C. Khosla, R. R. Smeby, F. M. Bumpus
    Pages 126-161
  7. R. K. Türker, I. H. Page, F. M. Bumpus
    Pages 162-169
  8. John M. Stewart
    Pages 170-184
  9. G. W. Boyd, W. S. Peart
    Pages 211-226
  10. Philip A. Khairallah, Robert R. Smeby
    Pages 227-239
  11. E. G. Biglieri, J. R. Stockigt, M. Schambelan, R. D. Collins
    Pages 284-297
  12. J. C. Melby
    Pages 298-321
  13. J. R. Blair-West, J. P. Coghlan, D. A. Denton, B. A. Scoggins
    Pages 337-368

About this book


The history of arterial hypertension is both long and short; long, since BRIGHT (1827) first related hardness of the pulse to hardness of the kidneys and hyper. trophy of the heart; short in that modern research began in the late twenties. Most of what we know of these diseases has been discovered in the past fifty years. The modern story should have begun in 1897 when an extract of kidney was shown to be pressor. But little was done with knowledge until about 1929 when the relationship of this kidney extract called "renin" to hypertension was pos· tulated. The pressor effects were, however, unlike most of those seen with sub· stances such as epinephrine or vasopressin. Plasma was required for action of renin and the active substance appeared to be protein. In 1939, it was shown that renin was not in itself a pressor substance but rather a proteolytic enzyme which produced a powerful pressor substance acting on a substrate synthesized by the liver. Later it was noted that the first definable step after the formation of this peptide was cleaving of the decapeptide which had little or no demonstrable activity, with loss of two amino acids to form the octapeptide called "angiotensin". Within a decade synthesis was achieved which made the substance available for world·wide study.


Aldosteron Biotransformation Drogen Hormone Prostaglandin Serotonin anesthesia diagnosis diseases kidney nervous system pharmacokinetics pharmacology physiology research

Editors and affiliations

  • Irvine H. Page
    • 1
  • F. Merlin Bumpus
    • 2
  1. 1.The Cleveland Clinic FoundationClevelandUSA
  2. 2.Division of ResearchThe Cleveland Clinic FoundationClevelandUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1974
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-65602-6
  • Online ISBN 978-3-642-65600-2
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • About this book
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