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Effects of Aldosterone on Blood Pressure, Water, and Electrolytes

  • Chapter
Angiotensin

Abstract

Today it may be considered an anachronism to discuss aldosterone in a volume on angiotensin, since, during recent years, an increasing number of observations have been reported that cast doubts on the significance of angiotensin for the regulation of aldosterone secretion (Blair-West et al., 1968, 1971; Palmore et al., 1969; Müller, 1971, 1972; Boyd et al., 1972). However, the fact that the secretion of aldosterone is under multifactorial control should not divert from the results that prove a close relationship between the renin-angiotensin system and the aldosterone-producing cells of the adrenal cortex. It has been stressed repeatedly that angiotensin should not be characterized as the aldosterone-stimulating hormone or factor, because this might create the impression that no other factor but angiotensin has such an action (Gross, 1967). However, it would also be incorrect to disregard all the findings that clearly demonstrate a close humoral connection between the kidney and the zona glomerulosa of the adrenal cortex [Brown et al., 1972 (2)].

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Authors
  1. F. Gross
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Editors and Affiliations

  1. The Cleveland Clinic Foundation, 44106, Cleveland, OH, USA

    Irvine H. Page M.D. (Emeritus Director of Research) (Emeritus Director of Research)

  2. Division of Research, The Cleveland Clinic Foundation, 44106, Cleveland, OH, USA

    F. Merlin Bumpus Ph.D. (Chairman) (Chairman)

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Gross, F. (1974). Effects of Aldosterone on Blood Pressure, Water, and Electrolytes. In: Page, I.H., Bumpus, F.M. (eds) Angiotensin. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65600-2_19

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  • DOI: https://doi.org/10.1007/978-3-642-65600-2_19

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