Overview
- Editors:
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W. Richard Chegwidden
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Lake Erie College of Osteopathic Medicine, Erie, USA
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Nicholas D. Carter
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Medical Genetics Unit, St George’s Hospital Medical School, London, UK
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Yvonne H. Edwards
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MRC Human Biochemical Genetics Unit, Wolfson House, University College London, London, UK
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Table of contents (31 chapters)
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Front Matter
Pages I-XVIII
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Exordium: Remarks on the discovery of carbonic anhydrase
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- W. Richard Chegwidden, Nicholas D. Carter
Pages 13-28
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Carbonic Anhydrase Isoforms and their Expression in Mammals
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- Richard E. Tashian, David Hewett-Emmett, Nick Carter, Nils C. H. Bergenhem
Pages 105-120
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- Yvonne Edwards, Felicity Drummond, Jane Sowden
Pages 121-141
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- Yvonne Ridderstråle, Per J. Wistrand, Lena Holm, Nicholas D. Carter
Pages 143-155
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Structure and Mechanism
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Front Matter
Pages 157-157
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- Travis Stams, David W. Christianson
Pages 159-174
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- Sven Lindskog, David N. Silverman
Pages 175-195
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- Claudiu T. Supuran, Andrea Scozzafava
Pages 197-219
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- Jennifer A. Hunt, Charles A. Lesburg, David W. Christianson, Richard B. Thompson, Carol A. Fierke
Pages 221-240
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- Uno Carlsson, Bengt-Harald Jonsson
Pages 241-259
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Physiology
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Front Matter
Pages 261-261
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- Robert E. Forster, Susanna J. Dodgson
Pages 263-280
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- W. Richard Chegwidden, Susanna J. Dodgson, Ian M. Spencer
Pages 343-363
About this book
Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...
Editors and Affiliations
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Lake Erie College of Osteopathic Medicine, Erie, USA
W. Richard Chegwidden
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Medical Genetics Unit, St George’s Hospital Medical School, London, UK
Nicholas D. Carter
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MRC Human Biochemical Genetics Unit, Wolfson House, University College London, London, UK
Yvonne H. Edwards