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The Carbonic Anhydrases pp 79–93Cite as

Birkhäuser

An overview of the distribution and function of carbonic anhydrase in mammals

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Part of the book series: EXS 90 ((EXS,volume 90))

Abstract

During the last two decades, immunohistochemical approaches have greatly increased our understanding of the distribution and function of carbonic anhydrase (CA) in different organs. The availability of isoenzyme-specific antibodies to different CAs has made it possible to localize each isoenzyme at the cellular and subcellular levels, and this has attracted investigators to study their specific physiological role, based on a knowledge of the cell types expressing the enzyme. This review presents selected immunohistochemical data on CA isoenzymes in mammals and provides some functional correlations that could facilitate the understanding of the physiological role of CAs in different organs.

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Authors and Affiliations

  1. Departments of Anatomy and Clinical Chemistry, University of Oulu, F1N-90220, Oulu, Finland

    Seppo Parkkila

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  1. Seppo Parkkila
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  1. Lake Erie College of Osteopathic Medicine, 1858 West Grandview Boulevard, Erie, PA, 16509, USA

    W. Richard Chegwidden

  2. Medical Genetics Unit, St George’s Hospital Medical School, London, SW17 0RE, UK

    Nicholas D. Carter

  3. MRC Human Biochemical Genetics Unit, Wolfson House, University College London, 4, Stephenson Way, London, NW1 2HE, UK

    Yvonne H. Edwards

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Parkkila, S. (2000). An overview of the distribution and function of carbonic anhydrase in mammals. In: Chegwidden, W.R., Carter, N.D., Edwards, Y.H. (eds) The Carbonic Anhydrases. EXS 90, vol 90. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8446-4_4

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