Abstract
Since the discovery, almost 70 years ago, of the enzyme carbonic anhydrase (CA), which plays an important role in the red blood cell by catalyzing the hydration of carbon dioxide (CO2 + H2O ↔ HCO– 3+ H+), a fascinating and complex story has unfolded of three enzyme families performing numerous functions in many different organisms.
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Baird TT, Waheed A, Okuyama T, Sly WS, Fierke CA (1997) Catalysis and inhibition of human carbonic anhydrase IV. Biochemistry 36: 2669–2678
Cabiscol E, Levine RL (1995) Carbonic anhydrase III. Oxidative modification in vivo and loss of phosphatase activity during ageing. J Biol Chem 270: 14742–14747
Cabiscol E, Levine RL (1996) The phosphatase activity of carbonic anhydrase III is reversibly regulated by glutathiolation. Proc Nalt Acad Sci USA 93: 4170–4174
Chegwidden WR (1991) Purification of the carbonic anhydrases. In: Dodgson SJ, Tashian RE, Gros G, Carter ND (eds.): The carbonic anhydrases: cellular physiology and molecular genetics. Plenum Press, New York, 101–118
Chegwidden WR, Tashian RE, Wiebauer KE (1995) CAIB: a second gene for human carbonic anhydrase I. Isozyme Bull 28: 36
Dodgson SJ, Forster RE II, Sly WS, Tashian RE (1988) Carbonic anhydrase activity of intact carbonic anhydrase-II deficient human erythrocytes. J Appl Physiol 65: 1472–1480
Earnhardt JN, Qian M, Tu C-K, Lakkis MM, Bergenhem NCH, Laipis PJ, Tashian RE, Silverman DN (1998) The catalytic properties of murine carbonic anhydrase VII. Biochemistry 37: 10837–10845
Feldstein JB, Silverman DN (1984) Purification and characterization of carbonic anhydrase from saliva of the rat. J Biol Chem 259: 5447–5453
Forster RE II (1991) Methods for the measurement of carbonic anhydrase activity. In: Dodgson SJ, Tashian RE, Gros G, Carter ND (eds.): The carbonic anhydrases: cellular physiology and molecular genetics. Plenum Press, New York, 79–98
Heck RW, Tanhauser SM, Manda R, Tu C-K, Laipis PJ, Silverman DN (1994) Catalytic properties of mouse carbonic anhydrase V JBiol Chem 269: 24742–24746
Henry RP (1991) Techniques for measuring carbonic anhydrase activity in vitro: the electrometric delta pH and pH stat methods. In: Dodgson SJ, Tashian RE, Gros G, Carter ND (eds.): The carbonic anhydrases: cellular physiology and molecular genetics. Plenum Press, New York, 119–125
Hewett-Emmett D, Tashian RE (1996) Functional diversity, conservation and convergence in the evolution of the α-, β-, and γ-carbonic anhydrase gene families. Mol Phylogenet Evol 5: 50–77
Jewell DA, Tu C-K, Paranawithana SR, Tanhauser SM, Lograsso PV, Laipis PJ, Silverman DN (1991) Enhancement of the catalytic properties of human carbonic anhydrase III by site-directed mutagenesis. Biochemistry 30: 1484–1490
Khalifah RG (1971) The carbon dioxide hydration activity of carbonic anhydrase. J Biol Chem 246: 2561–2573
Kisker EI, Schindelin H, Alber BE, Ferry JG, Rees DC (1996) A left-handed β-helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophilia. EMBO J 15: 2323–2330
Koester MK, Pullan LM, Noltman EA (1981) The p-nitrophenyl phosphatase activity of muscle carbonic anhydrase. Arch Biochem Biophys 211: 632–642
Laforgia S, Morse B, Levy J, Barnea G, Cannizzaro LA, Li F, Nowell PC, Boghosian-Sell L, Glick J, Weston A, Harris CC, Drabkin H, Patterson D, Croce CM, Schlessinger J, Heubner K (1991) Receptor protein-tyrosine phosphatase γ is a candidate tumor suppressor gene at human chromosome region 3p21. Proc Natl Acad Sci USA 88: 5036–5040
Maren TH (1984) Carbonic anhydrase: the middle years, 1945–1960, and introduction to pharmacology of sulphonamides. Ann NY Acad Sci 429: 10–17
Maren TH, Conroy CW (1993) A new class of carbonic anhydrase inhibitor. J Biol Chem 268: 26233–26239
Mitsuhashi S, Mizushima T, Yamashita E, Yamamoto M, Kumasaka T, Moriyama H, Ueki T, Miyachi S, Tsukihara T (2000) X-ray structure of β-carbonic anhydrase from the red alga, Porphyridium purpureum, reveals a novel catalytic site for CO2 hydration. J Biol Chem 275:5521–5526
Mori K, Ogawa Y, Ebihara K, Tamura N, Tashiro K, Kuwaharal T, Mukoyama M, Sugawara A, Ozaki S, Tanaka I, Nakao K (1999) Isolation and characterization of CA XIV, a novel membrane-bound carbonic anhydrase from mouse kidney. J Biol Chem 274: 15701–15706
Murakami H, Sly WS (1987) Purification and characterization of human salivary carbonic anhydrase. J Biol Chem 262: 1382–1388
Parkkila A-K, Scarim AL, Parkkila S, Waheed A, Corbett JA, Sly WS (1998) Expression of carbonic anhydrase V in pancreatic beta cells suggests a role for mitochondrial carbonic anhydrase in insulin secretion. J Biol Chem 273: 24620–24623
Pocker Y, Sarkanen S (1978) Carbonic anhydrase: Structure, catalytic versatility, and inhibition. Adv Enzymol 47: 149–274
Räisänen SR, Lehenkari P, Tasanen M, Rahkila P, Harkonen PL, Vaananen HK (1999) Carbonic anhydrase III protects cells from hydrogen peroxide-induced apoptosis. FASEB J 13: 513–522
Rickli EE, Ghansanfar SAS, Gibbons BH, Edsall JT (1964) Carbonic anhydrase from human erythrocytes. Preparation and properties of two enzymes. J Biol Chem 239: 1065–1078
Silverman DN (1982) Carbonic anhydrase: oxygen-18 exchange catalysed by an enzyme with rate-contributing proton-transfer steps. In: DL Purich (ed.): Methods in enzymology, vol. 87, Academic Press, New York, 732–752
Sok J, Wang X-Z, Batchvarova N, Kuroda M, Harding H, Ron D (1999) CHOP-dependent stress-inducible expression of a novel form of carbonic anhydrase VI. Mol Cell Biol 19: 495–504
Sutton JR, Houston CS, Mansell AL, McFadden MD, Hackett PM, Rigg JRA, Powles ACP (1979) Effect of acetazolamide on hypoxemia during sleep at high altitude. New Eng J Med 301: 1329–1331
Sly WS, Hu PY (1995) Human carbonic anhydrases and carbonic anhydrase deficiencies. Ann Rev Biochem 64: 375–401
Verpoorte JA, Mehta S, Edsall JT (1967) Esterase activities of human carbonic anhydrases B and C. JBiol Chem 242: 4221–4229
Vince JW, Reithmeir RAF (1998) Carbonic anhydrase II binds to the Carboxyl Terminus of Human Band 3, the Erythrocyte Cl/HCO– 3 Exchanger. J Biol Chem 273: 28430–28437
Yang H, Nevo E, Tashian RE (1998) Unexpected expression of carbonic anhydrase I and selenium-binding protein as the only major non-haem proteins in erythrocytes of the subterranean mole rat (Spalaz ehrenbergi). FEBS Lett 430: 343–347
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Chegwidden, W.R., Carter, N.D. (2000). Introduction to the carbonic anhydrases. In: Chegwidden, W.R., Carter, N.D., Edwards, Y.H. (eds) The Carbonic Anhydrases. EXS 90, vol 90. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8446-4_2
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DOI: https://doi.org/10.1007/978-3-0348-8446-4_2
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