Skip to main content

Introduction to the carbonic anhydrases

  • Chapter
The Carbonic Anhydrases

Part of the book series: EXS 90 ((EXS,volume 90))

Abstract

Since the discovery, almost 70 years ago, of the enzyme carbonic anhydrase (CA), which plays an important role in the red blood cell by catalyzing the hydration of carbon dioxide (CO2 + H2O ↔ HCO 3+ H+), a fascinating and complex story has unfolded of three enzyme families performing numerous functions in many different organisms.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Baird TT, Waheed A, Okuyama T, Sly WS, Fierke CA (1997) Catalysis and inhibition of human carbonic anhydrase IV. Biochemistry 36: 2669–2678

    Article  PubMed  CAS  Google Scholar 

  • Cabiscol E, Levine RL (1995) Carbonic anhydrase III. Oxidative modification in vivo and loss of phosphatase activity during ageing. J Biol Chem 270: 14742–14747

    Article  PubMed  CAS  Google Scholar 

  • Cabiscol E, Levine RL (1996) The phosphatase activity of carbonic anhydrase III is reversibly regulated by glutathiolation. Proc Nalt Acad Sci USA 93: 4170–4174

    Article  CAS  Google Scholar 

  • Chegwidden WR (1991) Purification of the carbonic anhydrases. In: Dodgson SJ, Tashian RE, Gros G, Carter ND (eds.): The carbonic anhydrases: cellular physiology and molecular genetics. Plenum Press, New York, 101–118

    Google Scholar 

  • Chegwidden WR, Tashian RE, Wiebauer KE (1995) CAIB: a second gene for human carbonic anhydrase I. Isozyme Bull 28: 36

    Google Scholar 

  • Dodgson SJ, Forster RE II, Sly WS, Tashian RE (1988) Carbonic anhydrase activity of intact carbonic anhydrase-II deficient human erythrocytes. J Appl Physiol 65: 1472–1480

    PubMed  CAS  Google Scholar 

  • Earnhardt JN, Qian M, Tu C-K, Lakkis MM, Bergenhem NCH, Laipis PJ, Tashian RE, Silverman DN (1998) The catalytic properties of murine carbonic anhydrase VII. Biochemistry 37: 10837–10845

    Article  PubMed  CAS  Google Scholar 

  • Feldstein JB, Silverman DN (1984) Purification and characterization of carbonic anhydrase from saliva of the rat. J Biol Chem 259: 5447–5453

    PubMed  CAS  Google Scholar 

  • Forster RE II (1991) Methods for the measurement of carbonic anhydrase activity. In: Dodgson SJ, Tashian RE, Gros G, Carter ND (eds.): The carbonic anhydrases: cellular physiology and molecular genetics. Plenum Press, New York, 79–98

    Google Scholar 

  • Heck RW, Tanhauser SM, Manda R, Tu C-K, Laipis PJ, Silverman DN (1994) Catalytic properties of mouse carbonic anhydrase V JBiol Chem 269: 24742–24746

    CAS  Google Scholar 

  • Henry RP (1991) Techniques for measuring carbonic anhydrase activity in vitro: the electrometric delta pH and pH stat methods. In: Dodgson SJ, Tashian RE, Gros G, Carter ND (eds.): The carbonic anhydrases: cellular physiology and molecular genetics. Plenum Press, New York, 119–125

    Google Scholar 

  • Hewett-Emmett D, Tashian RE (1996) Functional diversity, conservation and convergence in the evolution of the α-, β-, and γ-carbonic anhydrase gene families. Mol Phylogenet Evol 5: 50–77

    Article  PubMed  CAS  Google Scholar 

  • Jewell DA, Tu C-K, Paranawithana SR, Tanhauser SM, Lograsso PV, Laipis PJ, Silverman DN (1991) Enhancement of the catalytic properties of human carbonic anhydrase III by site-directed mutagenesis. Biochemistry 30: 1484–1490

    Article  PubMed  CAS  Google Scholar 

  • Khalifah RG (1971) The carbon dioxide hydration activity of carbonic anhydrase. J Biol Chem 246: 2561–2573

    PubMed  CAS  Google Scholar 

  • Kisker EI, Schindelin H, Alber BE, Ferry JG, Rees DC (1996) A left-handed β-helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophilia. EMBO J 15: 2323–2330

    PubMed  CAS  Google Scholar 

  • Koester MK, Pullan LM, Noltman EA (1981) The p-nitrophenyl phosphatase activity of muscle carbonic anhydrase. Arch Biochem Biophys 211: 632–642

    Article  PubMed  CAS  Google Scholar 

  • Laforgia S, Morse B, Levy J, Barnea G, Cannizzaro LA, Li F, Nowell PC, Boghosian-Sell L, Glick J, Weston A, Harris CC, Drabkin H, Patterson D, Croce CM, Schlessinger J, Heubner K (1991) Receptor protein-tyrosine phosphatase γ is a candidate tumor suppressor gene at human chromosome region 3p21. Proc Natl Acad Sci USA 88: 5036–5040

    Article  PubMed  CAS  Google Scholar 

  • Maren TH (1984) Carbonic anhydrase: the middle years, 1945–1960, and introduction to pharmacology of sulphonamides. Ann NY Acad Sci 429: 10–17

    Article  PubMed  CAS  Google Scholar 

  • Maren TH, Conroy CW (1993) A new class of carbonic anhydrase inhibitor. J Biol Chem 268: 26233–26239

    PubMed  CAS  Google Scholar 

  • Mitsuhashi S, Mizushima T, Yamashita E, Yamamoto M, Kumasaka T, Moriyama H, Ueki T, Miyachi S, Tsukihara T (2000) X-ray structure of β-carbonic anhydrase from the red alga, Porphyridium purpureum, reveals a novel catalytic site for CO2 hydration. J Biol Chem 275:5521–5526

    Article  PubMed  CAS  Google Scholar 

  • Mori K, Ogawa Y, Ebihara K, Tamura N, Tashiro K, Kuwaharal T, Mukoyama M, Sugawara A, Ozaki S, Tanaka I, Nakao K (1999) Isolation and characterization of CA XIV, a novel membrane-bound carbonic anhydrase from mouse kidney. J Biol Chem 274: 15701–15706

    Article  PubMed  CAS  Google Scholar 

  • Murakami H, Sly WS (1987) Purification and characterization of human salivary carbonic anhydrase. J Biol Chem 262: 1382–1388

    PubMed  CAS  Google Scholar 

  • Parkkila A-K, Scarim AL, Parkkila S, Waheed A, Corbett JA, Sly WS (1998) Expression of carbonic anhydrase V in pancreatic beta cells suggests a role for mitochondrial carbonic anhydrase in insulin secretion. J Biol Chem 273: 24620–24623

    Article  PubMed  CAS  Google Scholar 

  • Pocker Y, Sarkanen S (1978) Carbonic anhydrase: Structure, catalytic versatility, and inhibition. Adv Enzymol 47: 149–274

    PubMed  CAS  Google Scholar 

  • Räisänen SR, Lehenkari P, Tasanen M, Rahkila P, Harkonen PL, Vaananen HK (1999) Carbonic anhydrase III protects cells from hydrogen peroxide-induced apoptosis. FASEB J 13: 513–522

    PubMed  Google Scholar 

  • Rickli EE, Ghansanfar SAS, Gibbons BH, Edsall JT (1964) Carbonic anhydrase from human erythrocytes. Preparation and properties of two enzymes. J Biol Chem 239: 1065–1078

    PubMed  CAS  Google Scholar 

  • Silverman DN (1982) Carbonic anhydrase: oxygen-18 exchange catalysed by an enzyme with rate-contributing proton-transfer steps. In: DL Purich (ed.): Methods in enzymology, vol. 87, Academic Press, New York, 732–752

    Google Scholar 

  • Sok J, Wang X-Z, Batchvarova N, Kuroda M, Harding H, Ron D (1999) CHOP-dependent stress-inducible expression of a novel form of carbonic anhydrase VI. Mol Cell Biol 19: 495–504

    PubMed  CAS  Google Scholar 

  • Sutton JR, Houston CS, Mansell AL, McFadden MD, Hackett PM, Rigg JRA, Powles ACP (1979) Effect of acetazolamide on hypoxemia during sleep at high altitude. New Eng J Med 301: 1329–1331

    Article  PubMed  CAS  Google Scholar 

  • Sly WS, Hu PY (1995) Human carbonic anhydrases and carbonic anhydrase deficiencies. Ann Rev Biochem 64: 375–401

    Article  PubMed  CAS  Google Scholar 

  • Verpoorte JA, Mehta S, Edsall JT (1967) Esterase activities of human carbonic anhydrases B and C. JBiol Chem 242: 4221–4229

    CAS  Google Scholar 

  • Vince JW, Reithmeir RAF (1998) Carbonic anhydrase II binds to the Carboxyl Terminus of Human Band 3, the Erythrocyte Cl/HCO 3 Exchanger. J Biol Chem 273: 28430–28437

    Article  PubMed  CAS  Google Scholar 

  • Yang H, Nevo E, Tashian RE (1998) Unexpected expression of carbonic anhydrase I and selenium-binding protein as the only major non-haem proteins in erythrocytes of the subterranean mole rat (Spalaz ehrenbergi). FEBS Lett 430: 343–347

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer Basel AG

About this chapter

Cite this chapter

Chegwidden, W.R., Carter, N.D. (2000). Introduction to the carbonic anhydrases. In: Chegwidden, W.R., Carter, N.D., Edwards, Y.H. (eds) The Carbonic Anhydrases. EXS 90, vol 90. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8446-4_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-8446-4_2

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9570-5

  • Online ISBN: 978-3-0348-8446-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics