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HIV and Dementia

Proceedings of the NIMH-Sponsored Conference “Pathogenesis of HIV Infection of the Brain: Impact on Function and Behavior”

  • Conference proceedings
  • © 1995

Overview

Editors:
  1. Michael B. A. Oldstone

    1. Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, USA

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  2. Ljubiša Vitković

    1. Molecular and Cellular Neuroscience Research Branch, Division of Neuroscience and Behavioral Science, National Institutes of Health, National Institute of Mental Health, Rockville, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 202)

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Table of contents (17 papers)

  1. Front Matter

    Pages I-XIII
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  2. The Human Problem: HIV, Neuropsychiatric Disorders, and Dementia

    1. Front Matter

      Pages 1-1
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    2. The Pathogenesis of HIV Infections of the Brain

      • R. T. Johnson
      Pages 3-10

    3. Neurocognitive Disorders in HIV-1 Infection

      • I. Grant, R. K. Heaton, J. H. Atkinson, the HNRC Group
      Pages 11-32

    4. AIDS Dementia Complex and HIV-1 Brain Infection: A Pathogenetic Framework for Treatment and Evaluation

      • R. W. Price
      Pages 33-54

    5. Quantitative Neuropathologic Assessment of HIV-1 Encephalitis

      • C. A. Wiley
      Pages 55-61

    6. Penetration of Solutes, Viruses, and Cells Across the Blood-Brain Barrier

      • M. W. Brightman, S. Ishihara, L. Chang
      Pages 63-78

    7. Cytotoxic T Lymphocytes and HIV-1-Related Neurologic Disorders

      • S. A. Kalams, B. D. Walker
      Pages 79-88

    8. Distinct HIV-1 env Sequences Are Associated with Neurotropism and Neurovirulence

      • C. Power, J. C. McArthur, R. T. Johnson, D. E. Griffin, J. D. Glass, R. Dewey et al.
      Pages 89-104

    9. Role for Astrocytosis in HIV-1-Associated Dementia

      • L. Vitković, A. da Cunha
      Pages 105-116

    10. Therapeutic Approaches to HIV Infection Based on Virus Structure and the Host Pathogen Interaction

      • C. D. Pauza, D. N. Streblow
      Pages 117-132

  3. Lentivirus Animal Models of HIV Central Nervous System Disease

    1. Front Matter

      Pages 133-133
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    2. Neurobiology of Simian and Feline Immunodeficiency Virus Infections

      • M. B. Gardner, S. Dandekar
      Pages 135-150

    3. Selected Models of HIV-Induced Neurological Disease

      • O. Narayan, S. V. Joag, E. B. Stephens
      Pages 151-166

    4. Feline Immunodeficiency Virus as a Model for Study of Lentivirus Infection of the Central Nervous System

      • S. J. Henriksen, O. Prospero-Garcia, T. R. Phillips, H. S. Fox, F. E. Bloom, J. H. Elder
      Pages 167-186

    5. Transgenic Models to Assess the Neuropathogenic Potential of HIV-1 Proteins and Cytokines

      • L. Mucke, E. Masliah, I. L. Campbell
      Pages 187-205

  4. Tissue Culture and Animal Models to Generate Basic Concepts on Viral Immune Cell: Central Nervous System Interactions

    1. Front Matter

      Pages 207-207
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    2. Virus Entry and Release in Polarized Epithelial Cells

      • R. W. Compans
      Pages 209-219

    3. Traffic of Hematogenous Cells Through the Central Nervous System

      • K. C. Williams, W. F. Hickey
      Pages 221-245

    4. Principles of Cytotoxic T Lymphocyte Induction and Recognition

      • J. L. Whitton, J. Zhang
      Pages 247-259
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Keywords

About this book

The National Institute of Mental Health (NIMH) AIDS Program is the fourth largest acquired immune deficiency syndrome (AIDS) program within the National Institutes of Health (NIH). Since 1983, our program's contributions have concentrated on two major areas. The first has been to develop effective strategies to prevent or reduce behaviors that place individuals at risk for human immunodeficiency virus type 1 (HIV-1) infection. The second has been to support and foster research to enhance our understanding of the profound impact of H IV-1 infection on the central nervous system (eNS). The brain appears to be a prime target of the virus and may serve as a reservoir for the virus. Post mortem examination of brain tissue has provided evidence of eNS cell damage in 80%-90% of people who die with AIDS. For about 10%-20% of people with AI DS, mild neuropsychological symptoms are the first signs of the disease. Approximately 20% of individuals infected with HIV-1 develop AIDS dementia complex. The symptoms include apathy, difficulty concentrat­ ing, irritability, depression, and personality changes. In the later stages of the disease, people may experience psychiatric disor­ ders. Death usually occurs within 6 months of the appearance of those more severe symptoms. Up to 90% of children infected with H IV-1 experience attention and concentration difficulties and often experience neurodevelopmental delay or regression over time.

Editors and Affiliations

  • Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, USA

    Michael B. A. Oldstone

  • Molecular and Cellular Neuroscience Research Branch, Division of Neuroscience and Behavioral Science, National Institutes of Health, National Institute of Mental Health, Rockville, USA

    Ljubiša Vitković

Bibliographic Information

  • Book Title: HIV and Dementia

  • Book Subtitle: Proceedings of the NIMH-Sponsored Conference “Pathogenesis of HIV Infection of the Brain: Impact on Function and Behavior”

  • Editors: Michael B. A. Oldstone, Ljubiša Vitković

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-79657-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1995

  • Softcover ISBN: 978-3-642-79659-3Published: 23 December 2011

  • eBook ISBN: 978-3-642-79657-9Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XIII, 279

  • Topics: Neurosciences, Cell Biology, Immunology

  • Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma

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