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The Pathogenesis of HIV Infections of the Brain

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HIV and Dementia

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 202))

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Abstract

Last summer, the World Health Organization estimated that over 13 million persons worldwide were infected with the human immunodeficiency virus (HIV) (Merson 1993). From prospective studies, it is reasonable to assume that the majority of these persons already have infection of the central nervous system; therefore, HIV is the most prevalent viral infection of the nervous system. It also can be assumed that during the next decade over 50% of these patients will develop disabling neurological diseases (dementia with HIV encephalopathy, paraparesis with vacuolar myelopathy, and disabling pain with predominantly sensory neuropathy); therefore, neurological complications of the acquired immunodeficiency syndrome (AIDS) will be among the commonest neurological diseases of the future.

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Authors and Affiliations

  1. The Departments of Neurology, Molecular Biology and Genetics, and Neuroscience, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 6-113, Baltimore, MD, 21287-7613, USA

    R. T. Johnson

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  1. R. T. Johnson
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Editors and Affiliations

  1. Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Michael B. A. Oldstone

  2. Molecular and Cellular Neuroscience Research Branch, Division of Neuroscience and Behavioral Science, National Institutes of Health, National Institute of Mental Health, 5600 Fishers Lane, Rm 11C-06, 20857, Rockville, MD, USA

    Ljubiša Vitković (Chief, Neuroimmunology/Neurovirology Program) (Chief, Neuroimmunology/Neurovirology Program)

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© 1995 Springer-Verlag Berlin Heidelberg

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Johnson, R.T. (1995). The Pathogenesis of HIV Infections of the Brain. In: Oldstone, M.B.A., Vitković, L. (eds) HIV and Dementia. Current Topics in Microbiology and Immunology, vol 202. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79657-9_1

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  • DOI: https://doi.org/10.1007/978-3-642-79657-9_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79659-3

  • Online ISBN: 978-3-642-79657-9

  • eBook Packages: Springer Book Archive

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