The Pathogenesis of HIV Infections of the Brain
Last summer, the World Health Organization estimated that over 13 million persons worldwide were infected with the human immunodeficiency virus (HIV) (Merson 1993). From prospective studies, it is reasonable to assume that the majority of these persons already have infection of the central nervous system; therefore, HIV is the most prevalent viral infection of the nervous system. It also can be assumed that during the next decade over 50% of these patients will develop disabling neurological diseases (dementia with HIV encephalopathy, paraparesis with vacuolar myelopathy, and disabling pain with predominantly sensory neuropathy); therefore, neurological complications of the acquired immunodeficiency syndrome (AIDS) will be among the commonest neurological diseases of the future.
KeywordsHuman Immunodeficiency Virus Human Immunodeficiency Virus Infection Acquire Immunodeficiency Syndrome Vacuolar Myelopathy Human Immunodeficiency Virus Encephalopathy
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