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HIV and Dementia

Proceedings of the NIMH-Sponsored Conference “Pathogenesis of HIV Infection of the Brain: Impact on Function and Behavior”

  • Michael B. A. Oldstone
  • Ljubiša Vitković

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 202)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. The Human Problem: HIV, Neuropsychiatric Disorders, and Dementia

    1. Front Matter
      Pages 1-1
    2. I. Grant, R. K. Heaton, J. H. Atkinson, the HNRC Group
      Pages 11-32
    3. M. W. Brightman, S. Ishihara, L. Chang
      Pages 63-78
    4. C. Power, J. C. McArthur, R. T. Johnson, D. E. Griffin, J. D. Glass, R. Dewey et al.
      Pages 89-104
    5. L. Vitković, A. da Cunha
      Pages 105-116
  3. Lentivirus Animal Models of HIV Central Nervous System Disease

    1. Front Matter
      Pages 133-133
    2. O. Narayan, S. V. Joag, E. B. Stephens
      Pages 151-166
    3. S. J. Henriksen, O. Prospero-Garcia, T. R. Phillips, H. S. Fox, F. E. Bloom, J. H. Elder
      Pages 167-186
  4. Tissue Culture and Animal Models to Generate Basic Concepts on Viral Immune Cell: Central Nervous System Interactions

    1. Front Matter
      Pages 207-207
    2. K. C. Williams, W. F. Hickey
      Pages 221-245
    3. G. F. Rall, M. B. A. Oldstone
      Pages 261-273
  5. Back Matter
    Pages 275-282

About this book

Introduction

The National Institute of Mental Health (NIMH) AIDS Program is the fourth largest acquired immune deficiency syndrome (AIDS) program within the National Institutes of Health (NIH). Since 1983, our program's contributions have concentrated on two major areas. The first has been to develop effective strategies to prevent or reduce behaviors that place individuals at risk for human immunodeficiency virus type 1 (HIV-1) infection. The second has been to support and foster research to enhance our understanding of the profound impact of H IV-1 infection on the central nervous system (eNS). The brain appears to be a prime target of the virus and may serve as a reservoir for the virus. Post mortem examination of brain tissue has provided evidence of eNS cell damage in 80%-90% of people who die with AIDS. For about 10%-20% of people with AI DS, mild neuropsychological symptoms are the first signs of the disease. Approximately 20% of individuals infected with HIV-1 develop AIDS dementia complex. The symptoms include apathy, difficulty concentrat­ ing, irritability, depression, and personality changes. In the later stages of the disease, people may experience psychiatric disor­ ders. Death usually occurs within 6 months of the appearance of those more severe symptoms. Up to 90% of children infected with H IV-1 experience attention and concentration difficulties and often experience neurodevelopmental delay or regression over time.

Keywords

AIDS HIV brain cognition cytokine dementia immunodeficiency infection nervous system neurobiology neuroscience pathogenesis physiology proteins virus

Editors and affiliations

  • Michael B. A. Oldstone
    • 1
  • Ljubiša Vitković
    • 2
  1. 1.Department of Neuropharmacology, Division of VirologyThe Scripps Research InstituteLa JollaUSA
  2. 2.Molecular and Cellular Neuroscience Research Branch, Division of Neuroscience and Behavioral ScienceNational Institutes of Health, National Institute of Mental HealthRockvilleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-79657-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-79659-3
  • Online ISBN 978-3-642-79657-9
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
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