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Neurocognitive Disorders in HIV-1 Infection

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Book cover HIV and Dementia

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 202))

Abstract

Neurocognitive disorder was noted to be associated with acquired immune deficiency syndrome (AIDS) even before HIV-1 was suspected of being the agent responsible for immunosuppression. Horowitz et al. (1982) observed that seven of nine patients suffering from gay-related immunodeficiency disorder, and who had CMV retinopathy as a complication, had neurological disorders, including disturbance in higher mental functioning. At the same time Britton et al. (1982) observed that three of their four patients with “gay-immunosuppressed syndrome” with neurological complications suffered from psychosis and dementia. In the following year Snider et al. (1983) reported that 18 of a series of 50 brains examined neuropathologically had evidence of subacute encephalopathy; furthermore, many of these patients exhibited, prior to death, clinical evidence of disturbed cognitive functioning and impaired ability to look after themselves.

The San Diego HIV Neurobehavioral Research Center (HNRC) Group is affiliated with the University of California, San Diego, the Naval Hospital, San Diego, and the San Diego VA Medical Center, and includes: I. Grant, M.D., Director, J.H. Atkinson, M.D., Co-Director; M. Kelly, Ph.D., Center Manager; J.A. McCutchan, M.D., P.I. Medical Core; S.A. Spector, M.D., P.I. Virology Core; L. Thal, M.D., P.I. Neurology Core; R.K. Heaton, Ph.D., P.I. Neuropsychology Core; J. Hesselink, M.D. and T. Jernigan, Ph.D., Co-P.I.s Imaging Core; J.H. Atkinson, M.D., P.I. Psychiatry Core; E. Masliah, M.D. and C.A. Wiley, M.D., Ph.D., Co-P.I.s Neuropathology Core; I. Abramson, Ph.D., P.I. Biostatistics Core; N. Butters, Ph.D., P.I. Memory Project; R. Dupont, M.D., P.I. SPECT Project; T. Patterson, Ph.D., P.I. Life Events Project; S. Zisook, M.D., P.I. Mood Project; D. Jeste, M.D., P.I. Psychosis Project. The principal support for the HNRC is provided by NIMH Center Grant 5 P50 MH45294 (HIV Neurobehavioral Research Center)

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Authors and Affiliations

  1. Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0680, USA

    I. Grant, R. K. Heaton & J. H. Atkinson

  2. Department of Veterans Affairs Medical Center, Psychiatry Service, 3350 La Jolla Village Drive, San Diego, CA, 92161, USA

    I. Grant & J. H. Atkinson

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Editors and Affiliations

  1. Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Michael B. A. Oldstone

  2. Molecular and Cellular Neuroscience Research Branch, Division of Neuroscience and Behavioral Science, National Institutes of Health, National Institute of Mental Health, 5600 Fishers Lane, Rm 11C-06, 20857, Rockville, MD, USA

    Ljubiša Vitković (Chief, Neuroimmunology/Neurovirology Program) (Chief, Neuroimmunology/Neurovirology Program)

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Grant, I., Heaton, R.K., Atkinson, J.H., the HNRC Group. (1995). Neurocognitive Disorders in HIV-1 Infection. In: Oldstone, M.B.A., Vitković, L. (eds) HIV and Dementia. Current Topics in Microbiology and Immunology, vol 202. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79657-9_2

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