Target Discovery and Validation Reviews and Protocols

Volume 2: Emerging Molecular Targets and Treatment Options

  • Mouldy Sioud

Part of the Methods in Molecular Biology™ book series (MIMB, volume 361)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Mouldy Sioud, Marianne Leirdal
    Pages 1-24
  3. Michel Herranz, Manel Esteller
    Pages 25-62
  4. Andreas Herbst, Frank Thomas Kolligs
    Pages 63-91
  5. Martha Chekenya, Heike Immervoll
    Pages 93-117
  6. Øyvind Melien
    Pages 119-144
  7. Chuanbo Zhang, Jin Pei, Deepak Kumar, Isamu Sakabe, Howard E. Boudreau, Prafulla C. Gokhale et al.
    Pages 163-185
  8. Laura Cerchia, Vittorio de Franciscis
    Pages 187-200
  9. Seyedhossein Aharinejad, Mouldy Sioud, Trevor Lucas, Dietmar Abraham
    Pages 227-238
  10. Richard O. Williams
    Pages 265-284
  11. Carlos R. Plata-Salamán, Sergey E. Ilyin
    Pages 299-309
  12. Marjorie P. Perron, Vincent Boissonneault, Lise-Andrée Gobeil, Dominique L. Ouellet, Patrick Provost
    Pages 311-326
  13. Mouldy Sioud, Øyvind Melien
    Pages 327-340
  14. Back Matter
    Pages 341-345

About this book

Introduction

Target Discovery and Validation Reviews and Protocols, Volumes 1 and 2 review the most progressive and current methods for drug target discovery and validation. These volumes explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders.

Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. The profound impact of genomics, proteomics and bioinformatics on target discovery is explored, and specific attention is given to the role of transgenic and knockout animals in functional genomics and target validation. Cancer researchers will find tremendous value in the molecular classification of breast cancers and the review of protocols for tumor antigens and cancer vaccines. The methods and protocols collected here, all reviewed by leading scientists and clinicians, present the practical details necessary for translating the enormous discovery potential of the genome into real therapeutic products.

Volume 2 collects all the practical details required for efficient translation of discovered targets into real pharmaceutical drugs. Specific targets in cancers and autoimmunity are described and the potential of using siRNAs, antisense oligonucleotides and RNA aptamers in patients is reviewed. This volume explores the tremendous impact of the application of genotyping and gene expression profiling on the future of healthcare, and presents cutting-edge protocols to aid in bringing agents against specific targets closer to application in the clinic.

Collectively, these volumes provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application. For researchers, an understanding of available methods aids in the creation of innovative experiments in the laboratory, and the successful translation of target discovery to real therapeutics.

Keywords

DNA Proteomics Translation bioinformatics classification gene expression molecular mechanisms

Editors and affiliations

  • Mouldy Sioud
    • 1
  1. 1.Department of Immunology, Institute for Cancer ResearchThe Norwegian Radium Hospital, University of OsloOsloNorway

Bibliographic information

  • DOI https://doi.org/10.1385/1597452084
  • Copyright Information Humana Press 2007
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-890-4
  • Online ISBN 978-1-59745-208-3
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • About this book
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