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Intracellular Delivery

Fundamentals and Applications

  • Aleš Prokop

Part of the Fundamental Biomedical Technologies book series (FBMT, volume 5)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Mechanisms of Uptake and Targeting

    1. Front Matter
      Pages 1-1
    2. Silvia Ferrati, Agathe K. Streiff, Srimeenakshi Srinivasan, Jenolyn F. Alexander, Nikhil Bhargava, Andrew M. Peters et al.
      Pages 3-55
    3. Béla Csukás, Mónika Varga, Aleš Prokop, Sándor Balogh
      Pages 125-154
    4. Lisa M. Kaminskas, Ben J. Boyd
      Pages 155-178
  3. Nanocarrier Formulation

    1. Front Matter
      Pages 197-197
    2. Rupa R. Sawant, Vladimir P. Torchilin
      Pages 199-223
    3. Julien Nicolas, Christine Vauthier
      Pages 225-250
    4. Xiao-Bing Xiong, Afsaneh Lavasanifar
      Pages 251-289
    5. Min-Hui Li
      Pages 291-331
    6. Sandrine Quignard, Sylvie Masse, Thibaud Coradin
      Pages 333-361
    7. Ivo Šafařík, Kateřina Horská, Mirka Šafaříková
      Pages 363-372
    8. Adam Schröfel, Gabriela Kratošová
      Pages 373-409
    9. Rainer H. Müller, Ranjita Shegokar, Sven Gohla, Cornelia M. Keck
      Pages 411-432
    10. Christine Vauthier, Kawthar Bouchemal
      Pages 433-456
  4. Medical Applications

    1. Front Matter
      Pages 457-457
    2. Eddy S. M. Lee, Brian K. Rutt, Nicholas M. Fisk, Shih-Chang Wang, Jerry Chan
      Pages 459-485
    3. Socorro Espuelas, Maite Agüeros, Irene Esparza, Juan M. Irache
      Pages 487-509
    4. Régis Vanderesse, Céline Frochot, Muriel Barberi-Heyob, Sébastien Richeter, Laurence Raehm, Jean-Olivier Durand
      Pages 511-565
    5. Qian Wang, Jing Liu
      Pages 567-598
    6. Jianxiang Zhang, Xiaohui Li, Liping Lou, Xiaodong Li, Yi Jia, Zhe Jin et al.
      Pages 599-699
    7. Joo-Hiuk Son, Seung Jae Oh, Jihye Choi, Jin-Suck Suh, Yong-Min Huh, Seungjoo Haam
      Pages 701-711
    8. O. A. Pinto, A. Tabaković, T. M. Goff, Y. Liu, J. H. Adair
      Pages 713-744
    9. Maria Jose Morilla, Eder Lilia Romero
      Pages 745-811
    10. Laura Rose, Ross Fitzsimmons, Tarek El-Bialy, Hasan Uludağ
      Pages 813-846
    11. Victor Maojo, Miguel García-Remesal, Diana de la Iglesia, José Crespo, David Pérez-Rey, Stefano Chiesa et al.
      Pages 847-860
  5. Back Matter
    Pages 861-867

About this book

Introduction

This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly existing conservative practices.

This volume is a collection of authoritative reviews. In the introductory part we define the field (intracellular delivery). Then, we first we cover fundamental routes of nanodelivery devices cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; all at academic and applied levels. Following is dedicated to enhancing delivery via special targeting motifs. Second, we introduce different types of intracellular nanodelivery devices (their chemistry, although the coverage is far from complete) and ways of producing these different devices. Third, we put special emphasis on particular disease states and on other biomedical applications. Diagnostic and sensing is also included.

The intracellular delivery/therapy is a very pregnant topic which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is a great potential for targeted delivery with improved localized delivery and efficacy.

Keywords

Cell Biology Fundamentals Delivery Intracellular Medicine Nanotechnology

Editors and affiliations

  • Aleš Prokop
    • 1
  1. 1., Chemical and Biological EngineeringVanderbilt UniversityNashvilleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-1248-5
  • Copyright Information Springer Science+Business Media B.V. 2011
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-1247-8
  • Online ISBN 978-94-007-1248-5
  • Series Print ISSN 1559-7083
  • Buy this book on publisher's site
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