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Intracellular Delivery pp 225–250Cite as

Poly(Alkyl Cyanoacrylate) Nanosystems

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Part of the book series: Fundamental Biomedical Technologies ((FBMT,volume 5))

Abstract

Poly(alkyl cyanoacrylate) nanosystems include various types of nanoparticles suitable to achieve in vivo drug delivery in a well controlled manner. Starting from general features on the synthesis of alkyl cyanoacrylate monomers and of their polymerization, this chapter aims to discuss how these monomers and corresponding polymers can be used to design drug delivery nanosystems with different properties.

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Abbreviations

(PIB-CA)3 :

three-arm star cyanoacrylate-telechelic polyisobutylene

ACA:

alkyl cyanoacrylate

AIBN:

azobisisobutyronitrile

Apo B-100:

apolipoprotein B-100

Apo E:

apolipoprotein E

Apo E3:

apolipoptotein E3

BBB:

blood-brain barrier

BFs:

breath figures method

DCC:

N,N  ’-dicyclohexylcarbodiimide

ddI:

didanosine

DXM:

dexamethasone

ECA:

ethyl cyanoacrylate

HA:

hyaluronic acid

HDCA:

hexadecyl cyanoacrylate

IBCA:

isobutyl cyanoacrylate

LDLR:

low-density lipoprotein receptors

MCA:

methyl cyanoacrylate

MePEG:

methoxypoly(ethylene glycol)

MePEG-b-PnBCA:

methoxypoly(ethylene glycol)-b-poly(n-butyl cyanoacrylate) diblock copolymer

MMA:

methyl methacrylate

MPS:

mononuclear phagocyte system

nBA:

n-butyl acrylate

nBCA:

n-butyl cyanoacrylate

NHS:

N-hydroxysuccinimide

NIPAAm:

N-isopropylacrylamide

NS:

nanosphere

Nu– :

charged nucleophile

Nu:

protic nucleophile

OCA:

octyl cyanoacrylate

o-NC:

oil-containing nanocapsule

P:

radical

P(ECA-co-MMA):

poly(ethyl cyanoacrylate-co-methyl methacrylate) copolymer

P(HDCA-co-MePEGCA):

poly[(hexadecyl cyanoacrylate)-co-methoxypoly(ethylene glycol) cyanoacrylate] copolymer

P(HDCA-co-N3PEGCA):

poly[(hexadecyl cyanoacrylate)-co -azidopoly(ethylene glycol) cyanoacrylate] copolymer

P(HDCA-co-NH2PEGCA):

poly[(hexadecyl cyanoacrylate)-co-aminopoly(ethylene glycol) cyanoacrylate] copolymer

P(HDCA-co-RCA-co-MePEGCA):

poly[hexadecyl cyanoacrylate-co-rhodamine B  cyanoacrylate-co-methoxypoly(ethylene glycol) cyanoacrylate] copolymer

P(HDCA-co-SelPEGCA):

poly[(hexadecyl cyanoacrylate)-co-selegiline-poly(ethylene  glycol)cyanoacrylate] copolymer

PACA:

poly(alkyl cyanoacrylate)

PECA:

poly(ethyl cyanoacrylate)

PECA-b-PEG-b-PECA:

poly(ethyl  cyanoacrylate)-b-poly(ethylene glycol)-b-poly(ethyl cyanoacrylate) triblock copolymer

PEG:

poly(ethylene glycol)

PHCA:

poly(hexyl cyanoacrylate)

PIBCA:

poly(isobutyl cyanoacrylate)

PIBCA-b-PEG:

poly(isobutyl cyanoacrylate)-b-poly(ethylene glycol) block copolymer

PIBCA-b-PEG-b-PIBCA:

poly(isobutyl cyanoacrylate)-b-poly(ethylene glycol)-b-poly(isobutyl cyanoacrylate) block copolymer

PnBCA:

poly(n-butyl cyanoacrylate)

PNIPAAm:

poly(N-isopropylacrylamide)

POCA:

poly(octyl cyanoacrylate)

SelPEGCA:

selegiline-poly(ethylene glycol) cyanoacetate

THF:

tetrahydrofuran

w/o/w:

water-in-oil-in-water

w/o:

water-in-oil

w-NC:

water-containing nanocapsule

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  1. Physico-chimie, Pharmacotechnie, Biopharmacie, Univ Paris-Sud, UMR 8612, Chatenay-Malabry, F-92296, France

    Julien Nicolas & Christine Vauthier

  2. CNRS, Chatenay-Malabry, F-92296, France

    Julien Nicolas & Christine Vauthier

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Nicolas, J., Vauthier, C. (2011). Poly(Alkyl Cyanoacrylate) Nanosystems. In: Prokop, A. (eds) Intracellular Delivery. Fundamental Biomedical Technologies, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1248-5_9

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