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Nanosized Drug Delivery Vectors and the Reticuloendothelial System

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Intracellular Delivery

Part of the book series: Fundamental Biomedical Technologies ((FBMT,volume 5))

Abstract

Nanomaterials have potential as drug delivery vectors that can improve the chemical stability and pharmacokinetic profile of small molecule drugs or improve drug uptake into solid tumours. However, one consequence of the use of nanosized drug delivery vectors is their potential recognition by tissue macrophages and accumulation in organs of the reticuloendothelial system (RES). While in some instances the uptake of drug loaded nanomaterials or ‘nanomedicines’ into organs of the RES is favoured, in most instances uptake into the RES can limit systemic exposure of the nanomedicine and limit therapeutic utility. Hence, this section discusses ways in which the RES uptake of nanomedicines can either be promoted or inhibited. Specifically, the effect of various physicochemical properties and presence or absence of key RES ‘recognition ligands’ on RES uptake are examined.

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Abbreviations

RES:

Reticuloendothelial system

PAMAM:

Polyamidoamine

PEG:

Polyethylene glycol

DPPC:

Dipalmitoyl phosphatidylglycerol

Succinate:

Succinic acid

Ph-sulphonate:

Benzene sulphonate

Ph-disulphonate:

Benzene disulphonate

TIM:

T cell Ig domain and mucin domain

NPC:

Non-parenchymal cell

HPI:

Hydrogenated phosphatidylinositol

DPPG:

1,2-dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol)

DAB:

Diaminobutane

Gd-DAB:

Gadolinium conjugated diaminobutane dendrimer

HLA-DR:

Human leukocyte antigen DR

BAI:

Brain specific angiogenesis inhibitor

GM1:

Monosialoganglioside GM1

DPPC:

1,2-dipalmitoyl-sn-glycero-3-phosphocholine

DSPC:

L-alpha-phosphatidylcholine distearoyl

DSPG:

L-alpha-phosphatidyl-DL-glycerol-distearoyl

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Authors and Affiliations

  1. Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia

    Lisa M. Kaminskas & Ben J. Boyd

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  1. Lisa M. Kaminskas
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  2. Ben J. Boyd
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Correspondence to Ben J. Boyd .

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  1. , Chemical and Biological Engineering, Vanderbilt University, VU Station B 351604, Nashville, 37235, Tennessee, USA

    Aleš Prokop

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Kaminskas, L.M., Boyd, B.J. (2011). Nanosized Drug Delivery Vectors and the Reticuloendothelial System. In: Prokop, A. (eds) Intracellular Delivery. Fundamental Biomedical Technologies, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1248-5_6

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