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Intracellular Delivery pp 57–72Cite as

Approaches to Achieving Sub-cellular Targeting of Bioactives Using Pharmaceutical Nanocarriers

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Part of the book series: Fundamental Biomedical Technologies ((FBMT,volume 5))

Abstract

It is well accepted that the ability of a biologically molecule to selectively find its target influences its potential as a successful therapeutic drug. For many molecules the molecular target is located inside sub-cellular structures. Molecules with such sub cellular targets and the inability to specifically accumulate at the location of the target can potentially be made more active by targeting strategies that improve their accumulation at the target. Pharmaceutical nanocarriers form the basis of several such targeting strategies. This chapter deals with the rational approach underlying the current uses of nanocarriers to deliver bioactive molecules to sub cellular compartments.

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  1. Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, 179 Longwood Ave, Boston, MA, 02115, USA

    Melani Solomon & Gerard G. M. D’Souza

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  2. Gerard G. M. D’Souza
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Correspondence to Gerard G. M. D’Souza .

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  1. , Chemical and Biological Engineering, Vanderbilt University, VU Station B 351604, Nashville, 37235, Tennessee, USA

    Aleš Prokop

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Solomon, M., D’Souza, G.G.M. (2011). Approaches to Achieving Sub-cellular Targeting of Bioactives Using Pharmaceutical Nanocarriers. In: Prokop, A. (eds) Intracellular Delivery. Fundamental Biomedical Technologies, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1248-5_2

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