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Therapeutic Angiogenesis for Vascular Diseases

Molecular Mechanisms and Targeted Clinical Approaches for the Treatment of Angiogenic Disease

  • Book
  • © 2011

Overview

Editors:
  1. Mark Slevin

    1. , SBCHS, John Dalton Building, Manchester Metropolitan University, Manchester, United Kingdom

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  • A definitive guide to the pathology of all the major angiogenic diseases
  • Detailed description of the latest medical imaging and treatment protocols
  • Concise overview of the mechanisms of angiogenesis in health and disease

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Modified 3D-Fibrin Matrices in Tissue Engineering for Stimulation of Angiogenesis and Wound Healing

    • Heike Hall
    Pages 1-26

  3. Ocular Retinopathies and Clinical Control of Angiogenesis

    • Bin Zhang, Jian-xing Ma
    Pages 27-65

  4. Angiogenic Gene Therapy for the Treatment of Retinopathies

    • Jacob M. Jones, Trevor McFarland, J. Timothy Stout
    Pages 67-80

  5. Angiogenesis in Tumour Development and Metastasis

    • Jessica J. Kandel, Darrell J. Yamashiro, Jan Kitajewski
    Pages 81-93

  6. Cancer Therapy by Targeting Vascular Endothelial Cell Growth Factor- and Non-Vascular Endothelial Cell Growth Factor-Mediated Angiogenesis

    • Yihai Cao
    Pages 95-113

  7. Molecular Mechanisms of Post-Ischemic Angiogenesis in the Brain

    • Heike Beck
    Pages 115-143

  8. Angiogenesis, the Neurovascular Niche and Neuronal Reintegration After Injury

    • Erin Lavik, Joseph A. Madri
    Pages 145-167

  9. Safe and Effective Vascular Endothelial Cell Growth Factor (VEGF)-based Therapeutic Angiogenesis for Ischemic Stroke: Insights from Preclinical Trials

    • Panya S. Manoonkitiwongsa, Robert L. Schultz, Patrick D. Lyden
    Pages 169-212

  10. Atherosclerotic Plaque Angiogenesis as a Mechanism of Intraplaque Hemorrhage and Acute Coronary Rupture

    • Frank D. Kolodgie, Aloke V. Finn, Jagat Narula, Renu Virmani
    Pages 213-236

  11. Neovascularization and Intra-plaque Hemorrhage: Role of Haptoglobin, Macrophages, and Heme-Oxygenase-1 Pathway

    • K-Raman Purushothaman, Meerarani Purushothaman, Andrew P. Levy, Samin K. Sharma, Valentin Fuster, Pedro R. Moreno
    Pages 237-256

  12. Angiogenic Approaches for Inhibition of Plaque Destabilization in Atherosclerosis

    • Konstantinos Toutouzas, Andreas Synetos, Christodoulos Stefanadis
    Pages 257-265

  13. A Key Role of Angiogenic Control in Recovery from Ischaemic Heart Disease

    • John F. O’Sullivan, Anne-Laure Leblond, Noel M. Caplice
    Pages 267-294

  14. Angiogenic Mediators and the Pathogenesis of Alzheimer’s Disease

    • Paula Grammas
    Pages 295-312

  15. Vascular Development, Stroke and Neurodegenerative Disease: A Place for Novel Clinical Interventions?

    • Adrià Arboix, Marta Grau-Olivares, Jerzy Krupinski
    Pages 313-338

  16. Peripheral Artery Disease and Angiogenesis: A Link Between Angiogenesis and Atherothrombosis

    • Philip C. Bennett, Stanley Silverman, Paramjit Gill, Gregory Y.H. Lip
    Pages 339-359

  17. Role of Angiogenesis in the Pathogenesis of Arthritis: Potential Therapeutic Applications

    • Serafim Kiriakidis, Ewa M. Paleolog
    Pages 361-382

  18. Angiogenesis and Giant Cell Arteritis

    • Sarah L. Mackie, Ann W. Morgan, Pamela F. Jones
    Pages 383-402

  19. Moyamoya Disease

    • Ahmed Itrat, Ayeesha Kamal
    Pages 403-416

  20. “Overview on Nanotechnology and Angiogenesis in Major Diseases Processes”

    • Judith Sendra Cuadal, Mercè Morral, Marc Ramis-Castelltort
    Pages 417-424
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Keywords

About this book

Angiogenesis is the growth of new blood vessels and is a key process which occurs during pathological disease progression. Excessive and damaging angiogenesis occurs in diseases such as cancer, diabetic retinopathies, age-related macular degeneration and atherosclerosis. In other diseases such as stroke and myocardial infarction, insufficient or improper angiogenesis results in tissue loss and ultimately higher morbidity and mortality. In this book we will begin by providing the reader with an overview of the process of angiogenesis including normal embryological development of blood vessels. The following chapters will each focus on a key angiogenic disease incorporating current scientific knowledge concerning the causes of activation of the “angiogenic switch”, pathological consequences, current treatment options and future perspectives. Where appropriate, results from pre-clinical trials, novel imaging modalities and nanotechnological approaches will be incorporated into these sections. Finally, since it is now believed that the process of angiogenesis operated via different signalling mechanisms in different vascular beds, we will discuss our current understanding of this phenomenon. The target audience for this book would include researchers in all the basic sciences; post-graduate students at Universities and Institutes; pharmaceutical industries; clinicians working in vascular biology or tissue imaging; pathologists; neurologists; tumour biologists; ophthalmologists and cardiologists.

Editors and Affiliations

  • , SBCHS, John Dalton Building, Manchester Metropolitan University, Manchester, United Kingdom

    Mark Slevin

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