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Molecular Mechanisms of Post-Ischemic Angiogenesis in the Brain

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Therapeutic Angiogenesis for Vascular Diseases

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Abstract

Angiogenesis, the growth of new blood vessels, could be interpreted as a natural defense mechanism helping to restore oxygen and nutrient supply to the ischemic brain tissue. This chapter will summarize molecular mechanisms of post-ischemic angiogenesis including observations regarding the timing of new vessel formation, change of expression of angiogenic factors as well as data describing the recruitment of endothelial progenitor cells towards the infarcted brain. Finally, this book chapter will focus on therapeutic attempts to increase post-ischemic angiogenesis in the brain.

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  1. Walter Brendel Center of Experimental Medicine, Institute of Cardiovascular Physiology, Ludwig-Maximilians University Munich, Marchioninistr, 27, 81377, Munich, Germany

    Heike Beck

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Beck, H. (2010). Molecular Mechanisms of Post-Ischemic Angiogenesis in the Brain. In: Slevin, M. (eds) Therapeutic Angiogenesis for Vascular Diseases. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9495-7_6

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