Allergic Reactions to Drugs

  • Alain L. de Weck
  • Hans Bundgaard

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 63)

Table of contents

  1. Front Matter
    Pages I-XXXI
  2. General Aspects of Drug Allergies

  3. Allergic Reactions to Specific Drugs

    1. Front Matter
      Pages 241-241
    2. E. S. K. Assem
      Pages 259-275
    3. E. S. K. Assem
      Pages 299-312
    4. K. E. Andersen, H. I. Maibach
      Pages 313-377
    5. A. A. Fisher
      Pages 379-390
    6. A. L. de Weck
      Pages 423-482
    7. D. Kraft
      Pages 483-520

About this book

Introduction

According to most studies, allergic reactions represent 35%-50% of all untoward reactions to drugs, yet the pharmacological literature concerning the clinical aspects, diagnosis, and pathophysiological mechanisms of drug allergy is markedly less extensive than reports dealing with the toxicological or pharmacological effects of drugs. The main reasons for this state of affairs may be on the one hand that until a few years ago the pathophysiological mechanisms of the various types of allergic reactions were not well understood, and on the other hand that objective diagnosis of a drug allergy is still fraught with serious difficulties. Drug allergy is still an unpopular topic for most allergologists and pharmacologists; this is reflected by the fact that despite their frequency, allergic reactions to drugs still occupy a relatively small proportion of space in most pharmacology handbooks and in classical books devoted to the side effects of drugs. There has recently been considerable progress in research into the immunologi­ cal and pathophysiological events occurring in allergic reactions, and on that basis investigations of various drug allergies have also yield~d new objective findings. Consequently, it was natural to attempt a review of the most frequent and important drug allergies in the form of a handbook. We originally intended to present a comprehensive review of all drug allergies, but the realization of this goal soon became more difficult than we had at first imagined.

Keywords

Acridin Aldehyde Chloramphenicol Histamin Hormone Insulin Nicotinamid Phenothiazine Vitamin A Vitamin B2 Vitamin D Vitamin E allergy drug pharmacology

Editors and affiliations

  • Alain L. de Weck
    • 1
  • Hans Bundgaard
    • 2
  1. 1.Institut für klinische Immunologie, InselspitalBernSwitzerland
  2. 2.Department of Pharmaceutical Chemistry ADThe Royal Danish School of PharmacyCopenhagenDenmark

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-69088-4
  • Copyright Information Springer-Verlag Berlin Heidelberg 1983
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-69090-7
  • Online ISBN 978-3-642-69088-4
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • About this book
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