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Epidemiology of Drug Allergy: Drug Monitoring

  • Chapter
Allergic Reactions to Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 63))

Abstract

The interval between the initial observation of symptoms and syndromes and the final recognition of a disease entity, with known pathogenesis or aetiology, may be a long one and much careful investigation may be necessary. At one end of the whole procedure is clinical observation and at the other, medical science and epidemiology. This principle also holds true for adverse drug effects and drug-induced illnesses. In any system designed to detect adverse reactions to drugs it is of fundamental importance to observe each syndrome or symptom and to record it, independently of its interpretation (Hoigné 1978). Evaluation can follow two distinct routes: a review of interpreted, individual data, or a statistical analysis of non-or not extensively interpreted events.

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References

  • Arndt K, Jick H (1976) Rates of cutaneous reactions to drugs. JAMA 235:918–923

    Article  PubMed  CAS  Google Scholar 

  • Baumgartner A, Hoigné R, Müller U, Hess T (1982) Medikamentöse Schäden des Blutbildes. Erfahrungen aus dem Komprehensiven Spital-Drug-Monitoring Bern, 1974–1979. Schweiz med Wochenschr 112:1530–1539

    Google Scholar 

  • Böttiger LE, Westerholm B (1973) Drug-induced blood dyscrasias in Sweden. Br med J 3:339–343

    Article  PubMed  Google Scholar 

  • Coombs RRA, Gell PGH (1963) The classification of allergic reactions underlying disease. In: Clinical aspects of immunology. Gell PGH, Coombs RRA (eds.) Blackwell Scientific, Oxford, pp 317–337

    Google Scholar 

  • de Weck A (1971) Acetyl-Salicylsäure: ein altes Arzneimittel in neuerem Blickwinkel. Dtsch Med Wochenschr 96:1109–1115

    Article  PubMed  Google Scholar 

  • Dukes MNG (1978) Drug utilization studies: a perspective. In: Ducrot H, Goldberg M, Hoigné R, Middleton P (eds.) IFIP TC-4 working conference on computer aid to drug therapy and to drug monitoring, Berne. North-Holland, Amsterdam Oxford New York, pp 373–377

    Google Scholar 

  • Dunne JF (1978) Spontaneous reporting of adverse reactions to drugs. In: Ducrot H, Goldberg M, Hoigné R, Middleton P (eds.) IFIP TC-4 working conference on computer aid to drug therapy and to drug monitoring, Berne. North-Holland, Amsterdam Oxford New York, pp 105–108

    Google Scholar 

  • Ettlin R, Hoigné R, Bruppacher R, Müller U, Stocker F (1981) Atopy and adverse drug reactions. Int Arch Allergy 66 (Suppl. 1):93–95

    Article  Google Scholar 

  • Finney DJ (1974) Systematic signalling of adverse reactions to drugs. Methods Inf Med 13:1–10

    PubMed  CAS  Google Scholar 

  • Fleiss JL (1973) Statistical methods for rates and proportions. John Wiley and Sons, New York Chichester, p 142

    Google Scholar 

  • Flicker U (1976) Exantheme bei Ampicillin- und Epicillintherapie. Medical dissertation, University of Berne

    Google Scholar 

  • Friedman GD (1974) Primer of epidemiology. McGraw-Hill, New York

    Google Scholar 

  • Friedman GD, Collen MF, Harris LE, Van Brunt EE, Davis LS (1971) Experience in monitoring drug reactions in outpatients. JAMA 217:567–572

    Article  PubMed  CAS  Google Scholar 

  • Green GR, Rosenblum A (1971) Report of the penicillin study group, American Academy of Allergy. J Allergy Clin Immunol 48:331–343

    Article  PubMed  CAS  Google Scholar 

  • Hoigné R (1965 a) Arzneimittel-Allergien. Huber Berne

    Google Scholar 

  • Hoigné R (1965 b) Penicillin hypersensitivity. In: Meyler L, Peck HM (eds) Drug-induced diseases. Excerpta Medica, Amsterdam, pp 89–96

    Google Scholar 

  • Hoigné R (1978) Monitoring of drug effects in outpatients: discussion. In: Ducrot H, Goldberg M, Hoigné R, Middleton P (eds) IFIP TC-4 working conference on computer aid to drug therapy and to drug monitoring, Berne. North-Holland, Amsterdam Oxford New York, p 97

    Google Scholar 

  • Hoigné R, Biedermann HP, Nägeli HR (1975) INH-induzierter systemischer Lupus erythematodes (SLE): 2 Beobachtungen mit Reexpositon. Schweiz Med Wochenschr 105:1726–1729

    Google Scholar 

  • Hoigné R, Ettlin R, Hintermann R et al. (1978) Die Auswahl antibakterieller Chemotherapeutika unter besonderer Berücksichtigung von Disposition und Grundkrankheit des Patienten. Schweiz Rundschau Med 67:1822–1828

    Google Scholar 

  • Hoigné R, Streit C, Stocker F et al. (1981) Drug Monitoring und Epidemiologie von Arzneimittel-Nebenwirkungen. In: Borelli S, Düngemann H (eds) Fortschritte der Allergologie und Dermatologie. Klinik für Dermatologie und Allergie, Davos and I.M.P. Verlagsgesellschaft, Basel Neu Isenburg Wien, pp 169–174

    Google Scholar 

  • Hurwitz N (1969 a) Predisposing factors in adverse reactions to drugs. Br Med J 1:536–539

    Article  PubMed  CAS  Google Scholar 

  • Hurwitz N, Wade OL (1969 b) Intensive hospital monitoring of adverse reactions to drugs. Br Med J 1:531–536

    Article  PubMed  CAS  Google Scholar 

  • Idsøe O, Guthe T, Willcox RR, de Weck AL (1969) Art und Ausmaß der Penizillinnebenwirkungen unter besonderer Berücksichtigung von 151 Todesfällen nach anaphylaktischem Schock. Schweiz Med Woschenschr 99:1190–1197, 1221–1229

    Google Scholar 

  • Inman WH, Adelstein AM (1969) Rise and fall of asthma mortality in England and Wales in relation to use of pressurised aerosols. Lancet 2:279–285

    Article  PubMed  CAS  Google Scholar 

  • Inman WHW (1982) Attitudes to type 1 (false positive) and type 2 (false negative) errors in assessment. In: Venulet J, Berneker GC, Ciucci AG (eds) Assessing causes of adverse drug reactions. Academic Press, London New York, pp 69–78

    Google Scholar 

  • Irey NS (1976) Adverse drug reactions and death. A review of 827 cases. JAMA 236:575–578

    Article  PubMed  CAS  Google Scholar 

  • Jämes D, Haller E, Rosselet G, Brooke EM, Schelling JL (1978) Fréquence des prescriptions de médicaments et de leurs effets indésirables dans un département de médecine. Schweiz Med Wochenschr 108:1270–1277

    PubMed  Google Scholar 

  • Jick H (1977) The discovery of drug-induced illness. N Engl J Med 296:481–485

    Article  PubMed  CAS  Google Scholar 

  • Jick H, Miettinen OS, Shapiro S, Lewis GP, Siskind V, Slone D (1970) Comprehensive drug surveillance. JAMA 213:1455–1460

    Article  PubMed  CAS  Google Scholar 

  • Karch FE, Lasagna L (1977) Toward the operational identification of adverse drug reactions. Clin Pharmacol Ther 21:247–254

    PubMed  CAS  Google Scholar 

  • Klein U, Klein M, Sturm H et al. (1976) The frequency of adverse drug reactions as dependent upon age, sex and duration of hospitalization. Int J Clin Pharmacol 13:187–195

    CAS  Google Scholar 

  • Koch-Weser J (1968) Definition and classification of adverse drug reactions. Drug Inform Bull 2:72–78

    Google Scholar 

  • Köhler CO, Kimbel KH (1978) Spontaneous monitoring data processing and information feedback to the physician. In: Ducrot H, Goldberg M, Hoigné R, Middleton P (eds) IFIP TC-4 working conference on computer aid to drug therapy and to drug monitoring, Berne. North-Holland, Amsterdam Oxford New York, pp 125–132

    Google Scholar 

  • Kurland L, Annegers JF, O’Fallon W (1978) Utilization of Mayo Clinic records for population-based long-term evaluations of drug exposure. In: Ducrot H, Goldberg M, Hoigné R, Middleton P (eds) IFIP TC-4 working conference on computer aid to drug therapy and to drug monitoring, Berne. North-Holland, Amsterdam Oxford New York, pp 69–76

    Google Scholar 

  • Lawson DH, Jick H (1976) Drug prescribing in hospitals: an international comparison. Am J Public health 66:644–648

    Article  PubMed  CAS  Google Scholar 

  • Lee SL, Rivero I, Siegel M (1966) Activation of systemic lupus erythematosus by drugs. Arch Intern Med 117:620–626

    Article  PubMed  CAS  Google Scholar 

  • Maronde RF, Rho J, Rucker TD (1978) Monitoring for adverse drug reactions including mutations, in outpatients. In: Ducrot H, Goldberg M, Hoigné R, Middleton P (eds) IFIP TC-4 working conference on computer aid to drug therapy and to drug monitoring, Berne. North-Holland, Amsterdam Oxford New York, pp 63–68

    Google Scholar 

  • Mayer RL (1933) Toxicodermien. In: Marchionini A, Nasemann T (eds) Die Viruskrank-heiten der Haut und die Hautsymptome bei Rickettsiosen und Bartonellosen. (Handbuch der Haut- und Geschlechtskrankheiten, vol IV/2, p 1) Springer, Berlin Heidelberg New York

    Google Scholar 

  • McFadden ER Jr, Austen KF (1977) Asthma. In: Thorn GW, Adams RD, Braunwald E, Isselbacher KJ, Petersdorf RG (eds) Harrison’s priciples of internal medicine, 8th edn. McGraw-Hill Kogakusha, Tokyo, pp 1349–1354

    Google Scholar 

  • Meyer UA (1978) Role of genetic factors in the rational use of drugs. In: Melmon KL, Morelli HF (eds) Clinical pharmacology. Basic principles in therapeutics, 2nd edn. Macmillan, New York, pp 913–929

    Google Scholar 

  • Miller RR (1973) Drug surveillance utilizing epidemiologic methods. A report from the Boston Collaborative Drug Surveillance Program. Am J Hosp Pharm 30:584–592

    PubMed  CAS  Google Scholar 

  • Pirquet C von, Schick B (1905) Die Serumkrankheit. Deutike, Leipzig Vienna

    Google Scholar 

  • Porter J, Jick H (1977) Drug-related deaths among medical inpatients. JAMA 237:879–881

    Article  PubMed  CAS  Google Scholar 

  • Rollof SL (1950) Erythema nodosum in association with sulfathiazole in children. Clinical investigation with special reference to primary tuberculosis. Acta Tuberc Scand [Suppl.] 24:1

    CAS  Google Scholar 

  • Shapiro S, Slone D, Siskind V, Lewis GP, Jick H (1969) Drug rash with ampicillin and other penicillins. Lancet 2:969–972

    Article  PubMed  CAS  Google Scholar 

  • Skegg DCG (1978) Use of record linkage for drug surveillance. A progress report. In: Ducrot H, Goldberg M, Hoigné R, Middleton P (eds) IFIP TC-4 working conference on computer aid to drug therapy and to drug monitoring, Berne. North-Holland, Amsterdam Oxford New York, pp 77–83

    Google Scholar 

  • Slone D, Shapiro S, Miettinen OS, Finkle WD, Stolley PD (1979) Drug evaluation after marketing. Ann Intern Med 90:257–261

    PubMed  CAS  Google Scholar 

  • Smith JW, Johnson JE III, Cluff LE (1966 a) Studies on the epidemiology of adverse drug reactions. II. An evaluation of penicillin allergy. N Engl J Med 274:998–1002

    Article  PubMed  CAS  Google Scholar 

  • Smith JW, Seidl LG, Cluff LE (1966 b) Studies on the epidemiology of adverse drug reactions. V. Clinical factors influencing susceptibility. Ann Intern Med 65:629–640

    PubMed  CAS  Google Scholar 

  • Speizer FE, Doll R, Haef P (1968) Observations on recent increase in mortality from asthma. Br Med J 1:335–339

    Article  PubMed  CAS  Google Scholar 

  • Streit C (1979) Das komprehensive Spital-Drug Monitoring Bern in methodischer Hinsicht. A) Methodik, unter besonderer Berücksichtigung der Prüfprogramme. B) Epidemiologie der makulo-papulösen Exantheme bei erwachsenen Patienten. Medical dissertation, University of Berne

    Google Scholar 

  • Török M, Zoppi M, Winzenried P, Marty H, Hess T, Stoller-Güleryüz D, Stucki P, Bickel MH, Stocker F, Hoigné R (1982) Drug related death among 17,285 inpatients in the division of internal medicine of two teaching hospitals in Berne, 1974–1980. In: Manell P, Johansson SG (eds) The impact of computer technology on drug information. North-Holland, Amsterdam, pp 79–84

    Google Scholar 

  • Venulet J (1982) Concluding remarks. In: Venulet J, Berneker GC, Ciucci AG (eds) Assessing causes of adverse drug reactions. Academic Press, London New York, pp 217–221

    Google Scholar 

  • WHO (1969) International drug monitoring. The role of the hospital. WHO Tech Rep Ser

    Google Scholar 

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Authors
  1. R. Hoigné
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  2. F. Stocker
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  3. P. Middleton
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Editor information

Editors and Affiliations

  1. Institut für klinische Immunologie, Inselspital, CH-3010, Bern, Switzerland

    Alain L. de Weck

  2. Department of Pharmaceutical Chemistry AD, The Royal Danish School of Pharmacy, 2, Universitetsparken, DK-2100, Copenhagen, Denmark

    Hans Bundgaard

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© 1983 Springer-Verlag Berlin Heidelberg

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Hoigné, R., Stocker, F., Middleton, P. (1983). Epidemiology of Drug Allergy: Drug Monitoring. In: de Weck, A.L., Bundgaard, H. (eds) Allergic Reactions to Drugs. Handbook of Experimental Pharmacology, vol 63. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69088-4_6

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  • DOI: https://doi.org/10.1007/978-3-642-69088-4_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69090-7

  • Online ISBN: 978-3-642-69088-4

  • eBook Packages: Springer Book Archive

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