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Prevention and Treatment of Drug Allergies

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 63))

Abstract

The problem of prevention and therapy of allergic reactions to drugs is complex and not yet satisfactorily resolved. Measures to reduce the incidence of allergic reactions to drugs may be taken at several levels, for instance by the manufacturer, the treating physician, or the patient himself.

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References

  • Agrup G (1972) Patch testing in drug allergy. In: Dash CH, Jones HEH (eds) Mechanisms of drug allergy. Churchill-Livingstone, Edinburgh/london, p 135

    Google Scholar 

  • Ahlstedt S, Ekstroem B, Svaerd PO, Sjoeberg B, Kristofferson A, Oertengren B (1980) New aspects on antigens in penicillin allergy. CRC Crit Rev Toxicol 7:219

    Article  CAS  Google Scholar 

  • Amkraut AA, Rosenberg LT, Raffel S (1963) Elicitation of PCA by univalent and divalent haptens. J Immunol 91:644

    PubMed  CAS  Google Scholar 

  • Basomba A, Pelaez A, Villalmanzo IG, Campos A (1978) Allergy to penicillin unsuccessfully treated with a haptenic inhibitor (Benzylpenicilloyl-N-formyllysine: BPO-Flys). A case report. Clin Allergy 8:341

    Article  PubMed  CAS  Google Scholar 

  • Batchelor FR, Dewdney JM, Feinberg JG, Weston RD (1967) A penicilloylated protein impurity as a source of allergy to benzylpenicillin and 6-amino-penicillanic acid. Lancet 1:1175

    Article  PubMed  CAS  Google Scholar 

  • Borel Y, Kilham L, Hyslop N, Borel H (1976) Isologous IgG-induced tolerance to benzyl-penicilloyl. Nature 261:49

    Article  PubMed  CAS  Google Scholar 

  • Bundgaard H, de Weck AL (1975) The role of aminoreactive impurities in acetylsalicylic acid allergy. Int. Arch. Allergy Appl. Immunol 49:119

    Article  CAS  Google Scholar 

  • Chase MW (1946) Inhibition of experimental drug allergy by prior feeding of the sensitizing agent. Proc Soc Exp Bio Med 61:257

    CAS  Google Scholar 

  • Chiorazzi N, Eshhar Z, Katz DH (1976) Induction of immunological tolerance to the major antigenic determinant of penicillin: a therapeutic approach to penicillin allergy, Proc Natl Acad Sci USA 72:2091

    Article  Google Scholar 

  • Coutinho A, Moeller G, Richter W (1974) Molecular basis of B cell activation. I. Mitogenicity of native and substitutes dextrans. Scand J Immunol 3:321

    Article  PubMed  CAS  Google Scholar 

  • De Weck AL (1975) Molecular mechanisms of T and B lymphocyte triggering. Int Arch Allergy Appl Immunol 49:247

    Article  PubMed  Google Scholar 

  • De Weck AL (1977 a) Drug reactions. In: Samter M (ed) Immunological diseases, 2nd ed. Little, Brown & Co., Boston, p 415

    Google Scholar 

  • De Weck AL (1977 b) Immune responses to environmental antigens which act on the skin (which special reference to the role of lymphokines in contact dermatitis). Fed Proc 36:1742

    PubMed  Google Scholar 

  • De Weck AL (1978) Application du RAST dans l’allergie à la pénicilline. Med Hyg 36:118

    Google Scholar 

  • De Weck AL, Eisen HN (1960) Some immunochemical properties of penicillenic acid, an antigenic determinant derived from penicillin. J Exp Med 112:1227

    Article  Google Scholar 

  • De Weck AL, Girard JP (1972) Specific inhibition of allergic reactions to penicillin in man by a monovalent hapten: II. Clinical studies. Int Arch Allergy Appl Immunol 42:798

    Article  PubMed  Google Scholar 

  • De Weck AL, Schneider CH (1972) Specific inhibition of allergic reactions to penicillin in man by a monovalent hapten: I. Experimental immunological and toxicologic studies. Int Arch Allergy 42:789

    Google Scholar 

  • De Weck AL, Schneider H (1980) Allergic and immunological aspects of therapy with cefotaxine and other cephalosporins. J Antimicrob Chemother 6:161

    Article  PubMed  Google Scholar 

  • De Weck AL, Schneider CH, Gutersohn J (1968) The role of penicilloylated protein impurities, penicillin polymers and dimers in penicillin allergy. Int Arch Allergy Appl Immunol 33:535

    Article  PubMed  Google Scholar 

  • De Weck AL, Schneider CH, Toffler O, Lazary S (1973) Inhibition of allergic reactions by monovalent haptens. In: Sehon A (ed) Mechanisms of reaginic allergy. Dekker, New York, p 323

    Google Scholar 

  • De Weck AL, Jeunet F, Schulz KH, Louis P, Girard JP, Grilliat JP, Moneret-Vautrin D et al. (1975) Clinical trial of Ro 6–0787: a monovalent specific hapten inhibitor of penicillin allergy. Z. Immunitätsforsch 150:138

    Google Scholar 

  • De Weck AL, Toffler O, Koleckarova M, Spengler M (1976) Theoretical basis and experimental studies on the prevention of allergic reactions to penicillins by a monovalent benzylpenicilloyl hapten. Chemotherapy 4:345

    Google Scholar 

  • Dewdney J (1977) Immunology of the antibiotics. In: Sela M (ed) The antigens, IV. Academic Press, New York, p 74

    Google Scholar 

  • Farah FS, Kern M, Eisen HN (1960) Specific inhibition of wheal-and-erythema responses with univalent haptens and univalent antibody fragments. J Exp Med 112:1211

    Article  PubMed  CAS  Google Scholar 

  • Felix RH, Comaish JS (1974) The value of patch and other skin tests in drug eruptions. Lancet 1:1017

    Article  PubMed  CAS  Google Scholar 

  • Frick OL, Nye W, Raffel S (1968) Anaphylactic reactions to univalent haptens. Immunology 14:563

    PubMed  CAS  Google Scholar 

  • Gorevic PD, Levine BB (1981) Desensitization of anaphylactic hypersensitivity specific for the penicilloate minor determinant of penicillin and carbenicillin. J Allergy clin Immunol 68:267

    Article  PubMed  CAS  Google Scholar 

  • Green I, Paul WE, Benacerraf B (1966) The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responders and as haptens in nonresponder guinea pigs. J Exp Med 123:859

    Article  PubMed  CAS  Google Scholar 

  • Grieco MH, Dubin MR, Robinson JL, Schwartz MJ (1964) Penicillin hypersensitivity in patients with bacterial endocarditis. Ann Intern Med 60:204

    PubMed  CAS  Google Scholar 

  • Howard JG, Mitchison NA (1975) Immunological tolerance. Prog Allergy 18:43

    PubMed  CAS  Google Scholar 

  • Katz DH, Hamaoka R, Benacerraf B (1972) Immunological tolerance in bone marrow derived lymphocytes. I. Evidence for an intracellular mechanism of inactivation of hapten-specific precursors of antibody-forming cells. J Exp Med 136:1404

    Article  PubMed  CAS  Google Scholar 

  • Klein U, Gikalov I, Keller M, Hoigné R (1972) “Drug monitoring” in der medizinischen Abteilung eines Regionalspitals. Schweiz Med Wochenschr 102:1083

    Google Scholar 

  • Kraft D, Roth A, Mischer P, Pichler H, Ebner H (1977) Specific and total serum IgE measurements in the diagnosis of penicillin allergy. A long term follow-up study. Clin Allergy 7:21

    Article  PubMed  CAS  Google Scholar 

  • Kristofferson A, Ahlstedt A, Pettersson E, Svaerd PO (1977) Antigens in penicillin allergy. I. A radioimmunoassay for detection of penicilloylated protein contaminants in penicillin preparations. Int Arch Allergy Appl Immunol 55:13

    Article  PubMed  CAS  Google Scholar 

  • Lee WY, Sehon AH (1975) Suppression of reaginic antibody formation II. The use of adoptive transfer system for the study of immunological unresponsiveness. J Immunol 114:837

    PubMed  CAS  Google Scholar 

  • Lee WY, Sehon AH (1976) Suppression of reaginic antibody formation IV. Suppression of reaginic antibodies to penicillin in the mouse. J Immunol 117:927

    PubMed  CAS  Google Scholar 

  • Lee WY, Hubbard BA, Gripps V, Sehon AH (1980) Abrogation of the antibenzylpenicilloyl (BPO) IgE Response with BPO-polyvinyl alcohol conjugates. Int Arch Allergy Appl Immunol 63:1

    Article  PubMed  CAS  Google Scholar 

  • Levine BB (1966) Immunochemical mechanisms of drug allergy. Ann Rev Med 17:23

    Article  PubMed  CAS  Google Scholar 

  • Magnusson B, Kligman AM (1970) Allergic contact dermatitis in the guinea pig. Thomas, Springfield, Ill

    Google Scholar 

  • Mattson JR, Patterson R, Roberts M (1975) Insulin therapy in patients with systemic insulin allergy. Arch Intern Med 135:818

    Article  PubMed  CAS  Google Scholar 

  • Mitchell GF, Humphrey JH, Williamson AR (1972) B cell tolerance induced by polymeric antigens I. Comparison of the dose and epitope density requirements for inactivation of primed and unprimed B cells in vivo. Eur J Immunol 5:361

    Google Scholar 

  • Mota I (1964) The mechanism of anaphylaxis I. Production and biological properties of “mast cell sensitizing” antibody. Immunology 7:681

    PubMed  CAS  Google Scholar 

  • Neftel KA„ Waelti M„ Spengler H„ Von Feiten A„ Weitzman SA„ Buergi H„ de Weck AL (1981) Neutropenia after penicillins: Toxic or immune-mediated? Klin Wochenschr 59:877

    Article  PubMed  CAS  Google Scholar 

  • Otz U, Schneider CH, de Weck AL, Gruden E, Gill TG (1978) Induction of immunological tolerance to the penicilloyl antigenic determinant I. Evaluation of BPO-amino acid polymers and copolymers in mice. Eur J Immunol 8:406

    Article  PubMed  CAS  Google Scholar 

  • Ovary Z, Karush F (1960) Studies on the immunologic mechanism of anaphylaxis: I. Anti-body-hapten interactions studied by passive cutaneous anaphylaxis in the guinea pig. J Immunol 84:409

    PubMed  CAS  Google Scholar 

  • Paley RS, Leskowitz S, Borel Y (1975) Effect on tolerance induction of the mode of attachment of the hapten to the carrier. J Immunol 115:1409

    PubMed  CAS  Google Scholar 

  • Parker CW (1980) Drug Allergy. In: Parker CW (ed) Clinical immunology. Saunders, Philadelphia p 1219

    Google Scholar 

  • Reismann RE, Rose NR, Witebsky E, Arbesman C (1962) Penicillin allergy and desensiti-zation. J Allergy Clin Immunol 33:178

    Google Scholar 

  • Ruegger R, Spengler H, de Weck AL, Dubach UC (1973) Immunologische Aspekte der Sensibilisierung auf Phenacetin. Dtsch Med Wochenschr 98:762

    Article  PubMed  CAS  Google Scholar 

  • Sawrat JH, Ponvert C, Burtin C, Soubrane C, Bender F, Paupe I (1976) Lymphocyte transformation, leukocyte migration, specific IgE, IgG, and IgM before, during and after penicillin treatment without adverse reaction. Acta Allergol 31:1

    Google Scholar 

  • Schneider CH, Otz U, Gruden E (1978) Induction of immunological tolerance to the penicilloyl antigenic determinant II. Evaluation of stable and unstable penicilloyl-dextrans. Eur J Immunol 8:410

    Article  PubMed  CAS  Google Scholar 

  • Schneider CH, Gruden E, Waelti M, Toffler O, de Weck AL, Jost R (1979) Monovalent elicitation of passive cutaneous anaphylaxis by N-1-DNCP-N-6-BPO-diaminohexane. Mol Immunol 16:269

    Article  PubMed  CAS  Google Scholar 

  • Sullivan TJ, Wedner JH, Skatz GS, Yiecies LD, Parker CW (1981) Skin test to detect penicillin allergy. J Allergy Clin Immunol 68. 171

    Article  PubMed  CAS  Google Scholar 

  • Van Arsdel PP Jr (1978) Adverse drug reactions. In: Middleton E Jr, Read CE, Ellis EF (eds). Allergy: principles and practice, Mosby, St. Louis, vol 2. pp 1133

    Google Scholar 

  • Wide L, Juhlin L (1971) Detection of penicillin allergy of the immediate-type by radio-immunoassay of reagins (IgE) to penicilloyl conjugates. Clin Allergy 1:171

    Article  PubMed  CAS  Google Scholar 

  • Zolov D, Redmond AP, Levine BB (1967) Immunological studies of desensitization in penicillin allergy. J Allergy Clin Immunol 39:107

    Google Scholar 

  • Zweiman B, Mishkin MM, Hildreth EA (1975) An approach to the performance of contrast studies in contrast material reactive persons. Ann Intern Med 83:159

    PubMed  CAS  Google Scholar 

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© 1983 Springer-Verlag Berlin Heidelberg

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De Weck, A.L. (1983). Prevention and Treatment of Drug Allergies. In: de Weck, A.L., Bundgaard, H. (eds) Allergic Reactions to Drugs. Handbook of Experimental Pharmacology, vol 63. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69088-4_8

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  • DOI: https://doi.org/10.1007/978-3-642-69088-4_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69090-7

  • Online ISBN: 978-3-642-69088-4

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