Botulinum Neurotoxins

  • Andreas Rummel
  • Thomas Binz

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 364)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Yukako Fujinaga, Yo Sugawara, Takuhiro Matsumura
    Pages 45-59
  3. Kinga Bercsenyi, Francesco Giribaldi, Giampietro Schiavo
    Pages 91-113
  4. Gudrun Ahnert-Hilger, Agnieszka Münster-Wandowski, Markus Höltje
    Pages 159-177
  5. Charles B. Shoemaker, George A. Oyler
    Pages 179-196
  6. Subramanyam Swaminathan
    Pages 197-218
  7. Martin B. Dorner, K. Melanie Schulz, Skadi Kull, Brigitte G. Dorner
    Pages 219-255
  8. Back Matter
    Pages 319-321

About this book

Introduction

Botulinum neurotoxins are the most toxic natural substances and represent a major threat to the population when intentionally released in bioterrorist attacks. On the other hand, during the past two decades botulinum neurotoxins have become established as indispensable drugs for the treatment of a variety of severe neurological disorders. The need for efficient countermeasures as well as the expansion into additional fields of therapeutic application, call for comprehensive information on the botulinum neurotoxin molecules and their mode of action. Our knowledge of this subject has made great strides in recent years, setting the stage for the development of new botulinum neurotoxin-based molecules and novel applications.

This book reviews the current status of basic botulinum neurotoxin research. The first part describes the genetic variability of the toxin-producing bacteria, and sheds light on each step from toxin ingestion to the abrogation of synaptic signaling including the intestinal passage and absorption, nerve cell binding and entry, and intracellular substrate cleavage. The remaining chapters detail progress made in detection methods for botulinum neurotoxins, the development of botulinum neurotoxin inhibitors, and strategies to refine the neurotoxins for further medicinal applications by means of recombinant technologies.

Keywords

BoNT light chain translocation SNAREcomplex proteins endotoxins neurotoxins transcytosis and internalization of Botulinus neurotoxins

Editors and affiliations

  • Andreas Rummel
    • 1
  • Thomas Binz
    • 2
  1. 1., Institut für ToxikologieMedizinische Hochschule HannoverHannoverGermany
  2. 2., Institut für Physiologische ChemieMedizinische Hochschule HannoverHannoverGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-33570-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 2013
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-33569-3
  • Online ISBN 978-3-642-33570-9
  • Series Print ISSN 0070-217X
  • About this book
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