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Nucleic Acid Therapeutics in Cancer

  • Book
  • © 2004

Overview

Editors:
  1. Alan M. Gewirtz

    1. Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA

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Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-x
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  2. Introduction and Perspective

    1. Front Matter

      Pages 1-1
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    2. Antisense Methodology

      • Fritz Eckstein
      Pages 3-13

    3. Nucleic Acid Therapeutics

      • Alan M. Gewirtz
      Pages 15-24

  3. Basic Methodology

    1. Front Matter

      Pages 25-25
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    2. Targeted Genome Modification Via Triple Helix Formation

      • Faye A. Rogers, Peter M. Glazer
      Pages 27-43

    3. Therapeutic Applications of Ribozymes

      • John J. Rossi
      Pages 45-64

    4. Use of Catalytic DNA in Target Validation and Therapeutics

      • Lun-Quan Sun
      Pages 65-79

    5. Targeted Destruction of Small, Stable RNAs

      • David A. Dunbar, Susan J. Baserga
      Pages 81-88

    6. Mechanism of Action of Antisense RNA in Eukaryotic Cells

      • Zuo Zhang, Gordon G. Carmichael
      Pages 89-104

  4. Delivery

    1. Front Matter

      Pages 105-105
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    2. The Transport of Oligonucleotides Into Cells

      • R. L. Juliano
      Pages 107-113

    3. Peptide-Mediated Delivery of Antisense Oligonucleotides and Related Material

      • Eric Vivès, Jean Philippe Richard, Bernard Lebleu
      Pages 115-127

    4. Molecular Vectors for Gene Delivery to Cancer Cells

      • Guy Zuber, Jean-Serge Remy, Patrick Erbacher, Pascale Belguise, Jean-Paul Behr
      Pages 129-140

  5. Targeting

    1. Front Matter

      Pages 141-141
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    2. Considerations on the Design of Antisense Oligonucleotides

      • Rosel Kretschmer-Kazemi Far, Jens M. Warnecke, Georg Sczakiel
      Pages 143-154

    3. Identification of Hybridization Accessible Sequence in Messenger RNA

      • Lida K. Gifford, Ponzy Lu, Alan M. Gewirtz
      Pages 155-163

  6. Clinical Targets

    1. Front Matter

      Pages 165-165
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    2. Nucleic Acids As Gene-Targeting Therapeutics

      • Joanna B. Opalinska, Susan E. Shetzline
      Pages 167-176

    3. Y900003 (Isis 3521) and G3139 (Genasense; Oblimersen)

      • C. A. Stein, Nathalie Dias, Luba Benimetskaya, Jan S. Jepsen, Johnathan C. H. Lai, Anthony J. Raffo
      Pages 177-197
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Keywords

About this book

A cutting-edge review of the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting and clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically.

Editors and Affiliations

  • Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA

    Alan M. Gewirtz

Bibliographic Information

  • Book Title: Nucleic Acid Therapeutics in Cancer

  • Editors: Alan M. Gewirtz

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59259-777-2

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2004

  • Hardcover ISBN: 978-1-58829-258-2Published: 25 March 2004

  • Softcover ISBN: 978-1-4684-9858-5Published: 26 July 2012

  • eBook ISBN: 978-1-59259-777-2Published: 25 March 2004

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: X, 221

  • Number of Illustrations: 44 b/w illustrations, 5 illustrations in colour

  • Topics: Oncology

  • Industry Sectors: Biotechnology, Health & Hospitals, Pharma

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