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Dopamine Receptor Agonists

  • Book
  • © 1984

Overview

Editors:
  1. George Poste

    1. Smith Kline & French Laboratories, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Stanley T. Crooke

    1. Smith Kline & French Laboratories, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: New Horizons in Therapeutics (NHTH)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xxv
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  2. Dopamine Receptors

    1. Front Matter

      Pages 1-1
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    2. Pharmacological and Biochemical Characterization of Two Categories of Dopamine Receptor

      • John W. Kebabian
      Pages 3-22

    3. Radioligand Binding Studies of Agonist Interactions with Dopamine Receptors

      • I. Creese, S. E. Leff, D. R. Sibley, M. W. Hamblin
      Pages 23-64

    4. Quantitative Assay of Dopamine Receptor Subtypes

      • Rita M. Huff, Perry B. Molinoff
      Pages 65-86

    5. Structure—Activity Relationships of Dopamine Receptor Agonists

      • Carl Kaiser
      Pages 87-137

    6. Peripheral Dopamine Receptors

      • M. G. Bogaert, W. A. Buylaert, R. A. Lefebvre, J. L. Willems
      Pages 139-155

    7. Pharmacological Significance of Pre- and Postsynaptic Dopamine Receptors

      • Salomon Z. Langer, Sonia Arbilla
      Pages 157-176

  3. Dopamine Agonist Function and Pharmacology

    1. Front Matter

      Pages 177-177
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    2. Dopamine

      • N. H. Neff, M. Hadjiconstantinou, Z. Lackovic
      Pages 179-194

    3. Vascular Dopamine and Dopamine Receptor Agonists

      • Barry A. Berkowitz, Robert Erickson, Bodgan Zabko-Potavpovich, Eliot H. Ohlstein
      Pages 195-208

    4. Dopamine Receptor Agonists and Hypertension

      • Mustafa F. Lokhandwala, Richard J. Barrett
      Pages 209-223

  4. Critical Concepts of Physiological and Molecular Mechanisms of Cardiovascular and Renal Function

    1. Front Matter

      Pages 225-225
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    2. Role of Inflammatory Cells in Metabolic and Cellular Alterations Underlying the Exaggerated Renal Prostaglandin and Thromboxane Synthesis in Ureter Obstruction

      • Philip Needleman
      Pages 227-235

    3. The Kidney and Hypertension

      • Arthur C. Guyton, R. Davis Manning, Thomas E. Lohmeier, John E. Hall
      Pages 237-258

    4. Molecular Mechanisms of Vasodilatation

      • Louis J. Ignarro, Carl A. Gruetter, Albert L. Hyman, Philip J. Kadowitz
      Pages 259-288
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Keywords

About this book

Dopamine, in addition to its importance as a precursor of norepinephrine, is now known to be an important neurotransmitter in regulating functional activities in a number of major organ systems, including the central ner­ vous system. the cardiovascular system, the kidney, and the gut. Recent advances in our understanding of the functional role of dopamine, its mechanism of action and the pharmacology of dopaminergic agents have occurred on a broad front. The last few years have witnessed significant progress in the identification and classification of central and peripheral dopamine receptors and the factors that affect their responsiveness to inhibitory and stimulatory ligands. These advances have been paralleled by new insights into the contribution of alterations in dopaminergic reg­ ulation in causing disease and the utility of dopamine agonists and an­ tagonists as therapeutic modalities. This volume, the first in a series of publications arising from the annual Smith Kline and French Research Symposium on New Horizons in Therapeutics, provides a comprehensive survey of current research on peripheral dopamine receptors and the physiologic and therapeutic con­ sequences of stimulating pre-and postsynaptic dopamine receptors. Research in dopamine pharmacology mirrors the remarkable ad­ vances that are occurring in the field of pharmacology at large as a con­ sequence of the involvement of an ever-larger number of scientific dis­ ciplines in the study of drug action.

Editors and Affiliations

  • Smith Kline & French Laboratories, Philadelphia, USA

    George Poste, Stanley T. Crooke

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