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Mechanisms of Receptor Regulation

  • Book
  • © 1985

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Editors:
  1. George Poste

    1. Smith Kline and French Laboratories, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Stanley T. Crooke

    1. Smith Kline and French Laboratories, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: New Horizons in Therapeutics (NHTH)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xxv
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  2. Receptor Regulation

    • Leonard Jarett, Robert M. Smith
    Pages 1-11

  3. Patterns in Receptor Behavior and Function

    • Jerry Kaplan
    Pages 13-36

  4. The Membrane Receptor for Epidermal Growth Factor

    • Joseph Schlessinger, Irit Lax, Shoshana Gill, Richard Kris, Towia A. Libermann, Menashe Bar-Eli et al.
    Pages 37-51

  5. The Insulin Receptor as a Tyrosine- Specific Protein Kinase

    • Lilli M. Petruzzelli, Laurel Stadtmauer, Roman Herrera, Mary Makowske, Sabyasachi Ganguly, Diane Tabarini et al.
    Pages 53-64

  6. Signal Transduction in Biological Membranes

    • Martin Rodbell
    Pages 65-73

  7. Receptor-Controlled Phosphatidylinositol 4,5-Bisphosphate Hydrolysis in the Control of Rapid Receptor-Mediated Cellular Responses and of Cellular Proliferation

    • R. H. Michell
    Pages 75-94

  8. Requirements for Steroid Hormone Action in Eucaryotic Cells

    • Bert W. O’Malley
    Pages 95-109

  9. Inositol Trisphosphate and Diacylglycerol as Intracellular Second Messengers

    • Michael J. Berridge
    Pages 111-130

  10. Ionic Signal Transduction by Growth Factors

    • W. H. Moolenaar, S. W. de Laat
    Pages 131-147

  11. Guanine-Nucleotide-Binding Regulatory Proteins

    • Alfred G. Gilman, Murray D. Smigel, Gary M. Bokoch, Janet D. Robishaw
    Pages 149-158

  12. Role of Cyclic-AMP-Dependent Protein Kinase in the Regulation of Cellular Processes

    • Edwin G. Krebs, Donald K. Blumenthal, Arthur M. Edelman, C. Nicholas Hales
    Pages 159-195

  13. The Homogeneity and Discreteness of Membrane Domains

    • Zanvil A. Cohn, Ralph M. Steinman
    Pages 197-206

  14. Internalization and Processing of Peptide Hormone Receptors

    • Pedro Cuatrecasas
    Pages 207-223

  15. Sorting and Recycling of Cell Surface Receptors and Endocytosed Ligands

    • Aaron Ciechanover, Alan L. Schwartz, Harvey L. Lodish
    Pages 225-253

  16. The Nicotinic Acetylcholine Receptor

    • Michael A. Raftery, Bianca M. Conti-Tronconi, Susan M. J. Dunn, Rebecca D. Crawford, David Middlemas
    Pages 255-278

  17. Adenylate-Cyclase-Coupled β- Adrenergic Receptors

    • Berta Strulovici, Jeffrey M. Stadel, Robert J. Lefkowitz
    Pages 279-294

  18. Control of Receptor Function by Homologous and Heterologous Ligands

    • Morley D. Hollenberg
    Pages 295-322

  19. Ligand-Receptor Interactions at the Cell Surface

    • Morley D. Hollenberg, H. Joseph Goren
    Pages 323-373

  20. Unique Tumor-Specific Antigens as Altered Cell-Surface Receptors

    • Hans Schreiber, Carter van Waes, Hans Josef Stauss
    Pages 375-394
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About this book

It is less than 80 years since John Newport Langley first proposed the role of "receptive substances" as the site of drug action from his obser­ vations on the effects of nicotine and curare at the myoneural junction. The many advances in our understanding of receptor biology that have occurred during the intervening period mirror the extraordinary growth of knowledge in the biological sciences and in cell and molecular biology in particular. Receptor biology, in common with many other topics in contemporary biology, is on the threshold of a transition from being a descriptive, phenomenological discipline to one in which underlying mechanisms and regulatory principles can be defined with increasing pre­ cision. This change, together with the evolution of powerful analytical techniques and timely convergence of ideas from a number of previously separate fields of inquiry, is generating an increasingly unified theoretical and experimental framework for the study of receptor function. These themes, and the mood of anticipation that a real understanding of receptor function in health and disease is emerging, are reflected in in this volume, which summarizes the proceedings of the Sec­ the papers ond Smith Kline & French Research Symposium on New Horizons in Therapeutics held in Philadelphia in 1984.

Editors and Affiliations

  • Smith Kline and French Laboratories, Philadelphia, USA

    George Poste, Stanley T. Crooke

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