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Unique Tumor-Specific Antigens as Altered Cell-Surface Receptors

  • Chapter
Mechanisms of Receptor Regulation

Part of the book series: New Horizons in Therapeutics ((NHTH))

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Abstract

Cancer is often viewed as a primary disturbance of cell division. One might, therefore, expect to find the critical alterations exclusively in the nucleus of the malignant cells. Interestingly, however, many of the products of cancer-inducing viral genes-so called oncogenes-have now been traced to the periphery of the cell, namely, the plasma membrane. Furthermore, several of these viral oncogenes appear to be derived from cellular genes that code for products active at the periphery of the cell: these include growth factors, their membrane-bound receptors, and membrane-associated enzymes (Newmark, 1982). Cell biologists and developmental biologists have, of course, argued for years that the cell surface is a major component in the control of growth, differentiation, and movement of cells (Moscona, 1974) and that alterations of cell surface molecules are likely to be critically important in the establishment of malignant behavior. Immunologic probes have an extreme sensitivity for discovering even very subtle alterations in a surface molecule that change a normal “self” molecule to an abnormal “altered-self” molecule. Immunologic analysis of the tumor cell surface might, therefore, be extremely useful for discovering cell surface changes that are important for causing malignant behavior of the cell.

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Authors and Affiliations

  1. Department of Pathology, The University of Chicago, La Rabida-University of Chicago Institute, Chicago, Illinois, 60649, USA

    Hans Schreiber, Carter van Waes & Hans Josef Stauss

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  1. Hans Schreiber
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  2. Carter van Waes
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  1. Smith Kline and French Laboratories, Philadelphia, Pennsylvania, USA

    George Poste  & Stanley T. Crooke  & 

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Schreiber, H., van Waes, C., Stauss, H.J. (1985). Unique Tumor-Specific Antigens as Altered Cell-Surface Receptors. In: Poste, G., Crooke, S.T. (eds) Mechanisms of Receptor Regulation. New Horizons in Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2131-6_19

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  • DOI: https://doi.org/10.1007/978-1-4613-2131-6_19

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