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Ligand-Receptor Interactions at the Cell Surface

  • Chapter
Mechanisms of Receptor Regulation

Part of the book series: New Horizons in Therapeutics ((NHTH))

Abstract

Over the past 20 years, studies of pharmacological receptors have undergone a veritable biochemical metamorphosis. The first thorough study of the binding of a pharmacologically active compound (atropine) to its receptor (muscarinic cholinergic: Paton and Rang, 1965) was soon followed by a multitude of studies of the binding of a variety of ligands to their putative receptors. Now, it is realized that receptor structures are dynamic cellular elements that display considerable structural and functional complexities. Thus, in order to measure the interaction of a ligand with its cell surface receptor, it is essential to have a grasp of the many variables that can affect such measurements. In this chapter, we attempt to provide a suitable context in which the measurements of ligand-receptor interactions can be interpreted, and we provide several models of receptor structure and function that have emerged over the past 10 years.

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  1. Endocrine Research Group, Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, T2N 4N1, Canada

    Morley D. Hollenberg (Faculty of Medicine)

  2. Endocrine Research Group, Department of Medical Biochemistry, Faculty of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada

    H. Joseph Goren

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Hollenberg, M.D., Goren, H.J. (1985). Ligand-Receptor Interactions at the Cell Surface. In: Poste, G., Crooke, S.T. (eds) Mechanisms of Receptor Regulation. New Horizons in Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2131-6_18

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