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Mechanisms of Receptor Regulation pp 207–223Cite as

Internalization and Processing of Peptide Hormone Receptors

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Part of the book series: New Horizons in Therapeutics ((NHTH))

Abstract

There are two major mechanisms of a general nature by which macro-molecules can gain entrance into intact, living cells (Pastan and Willingham, 1981a). One of these is generally referred to as fluid-phase endocytosis, which is a nonconcentrative, nonadsorptive mechanism that internalizes anything that happens to be in the surrounding medium of the cell. There are two basic organelles and pathways generally recognized for this process. In one of these, very small invaginations of the cell membrane at the surface pinch off and internalize as very small endocytic vesicles. These vesicles go directly to lysosomes, generally reaching them within minutes, where they fuse and dislodge their contents into these lysosomes. The other general process involves the fusing of large ruffles of the cell membrane, thus trapping into very large vesicles quite substantial quantities of the exterior medium. These large vacuoles or vesicles again travel rapidly to the area of lysosomal structures, and on impact these apper to shatter into many small vesicles, which subsequently fuse with the lysosomes.

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Authors and Affiliations

  1. Wellcome Research Laboratories, Burroughs Wellcome Company, Research Triangle Park, North Carolina, 27709, USA

    Pedro Cuatrecasas

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  1. Pedro Cuatrecasas
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Editors and Affiliations

  1. Smith Kline and French Laboratories, Philadelphia, Pennsylvania, USA

    George Poste  & Stanley T. Crooke  & 

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© 1985 Plenum Press, New York

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Cuatrecasas, P. (1985). Internalization and Processing of Peptide Hormone Receptors. In: Poste, G., Crooke, S.T. (eds) Mechanisms of Receptor Regulation. New Horizons in Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2131-6_13

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  • DOI: https://doi.org/10.1007/978-1-4613-2131-6_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9259-3

  • Online ISBN: 978-1-4613-2131-6

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