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Toxic Interfaces of Neurones, Smoke and Genes

Proceedings of the European Society of Toxicology Meeting Held in Kuopio, June 16–19, 1985

  • Conference proceedings
  • © 1986

Overview

Editors:
  1. Claire M. Chambers

    1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

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  2. Philip L. Chambers

    1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

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    You can also search for this editor in PubMed   Google Scholar

  3. Jouko Tuomisto

    1. Department of Environmental Hygiene and Toxicology, National Public Health Institute, Kuopio, Finland

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Archives of Toxicology (TOXICOLOGY, volume 9)

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Table of contents (102 papers)

  1. Genetic Influences on Toxicity

    1. Inter-Individual Variations in Carcinogen Metabolism

      • H. Autrup, R. Grafström, K. Vahakangas, C. C. Harris
      Pages 147-153

    2. Interethnic Differences in the Detoxification of Organophosphates: The Human Serum Paraoxonase Polymorphism

      • T. L. Diepgen, M. Geldmacher-v. Mallinckrodt
      Pages 154-158

    3. DNA-Mediated Restoration of Aryl Hydrocarbon Hydroxylase Induction in a Mouse Hepatoma Mutant Defective in Nuclear Translocation of the Ah Receptor

      • S. O. Kärenlampi, D. F. Montisano, J. M. Gudas, O. Hankinson
      Pages 159-162

    4. Species Differences in the Covalent Binding of p-Chloro-o-Toluidine to DNA

      • P. Bentley, F. Waechter, F. Bieri, W. Stäubli, W. Muecke
      Pages 163-166

    5. Effects of Peroxisome Proliferators in Vivo and in Primary Hepatocyte Cultures from Chinese and Syrian Hamsters

      • B. G. Lake, T. J. B. Gray, K. D. Hodder, J. A. Beamand, C. R. Stubberfield, S. D. Gangolli
      Pages 167-167

  2. Cardiovascular Toxicity

    1. Front Matter

      Pages 169-169
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    2. Cardiotoxicity Mechanisms from the Point of View of Preclinical or Premarketing Safety Evaluation

      • T. Balazs
      Pages 171-177

    3. Detection of Cardiotoxic Hazards

      • G. Zbinden
      Pages 178-187

    4. Interaction of Calcium Antagonists with β-Adrenoceptor Blocking Agents

      • L. Szekeres, J. Gy. Papp
      Pages 188-196

    5. Cardiotoxicity of Digitalis

      • K.-O. Haustein
      Pages 197-204

    6. Cardiotoxic Actions of Doxepin and Barium Chloride in Conscious Rabbits

      • M. J. Mattila, K. Anyos, E.-L. Puisto
      Pages 205-208

    7. Dose-Dependence of the Nifedipine/Digoxin Interaction?

      • H. J. Hutt, W. Kirch, P. Dylewicz, E. E. Ohnhaus
      Pages 209-212

    8. Experimental Compound OR-K-242-HCl an Anilide Derivative Slows Conduction Velocity of the Heart in the Conscious Beagle Dog

      • H. Hanhijärvi, H.-M. Voipio, H. Huuskonen, P. Männistö, T. Nevalainen
      Pages 213-216

    9. Nifedipine Induces Intense Nausea and Vomiting in Young, Healthy Volunteers

      • V. Saano, H. Komulainen
      Pages 217-218

    10. The Effect of a Novel Inotropic/Vasodilating Compound on the Dog Heart at Toxicological Doses

      • E. C. Joseph, R. J. Eden, T. F. Walker, J. H. Harleman
      Pages 219-219

  3. Routine Toxicity Testing: Problems and Solutions

    1. Front Matter

      Pages 221-221
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    2. Toxicology — the Next Decade

      • D. M. Conning
      Pages 222-224

    3. Application, Limitations and Research Requirements of in Vitro Test Systems in Toxicology

      • H. Greim, U. Andrae, U. Forster, L. Schwarz
      Pages 225-236

    4. The Questionable Value of Long-Term Animal Toxicity Studies: A Regulatory Dilemma

      • C. E. Lumley, S. R. Walker
      Pages 237-239

    5. To what Extent can Results of Experimental Studies be Extrapolated in Predicting Adverse Side Effects of Drugs in Man?

      • J. Grimová, Z. Roubal, A. Dlabač
      Pages 240-243
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Keywords

Editors and Affiliations

  • Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Claire M. Chambers, Philip L. Chambers

  • Department of Environmental Hygiene and Toxicology, National Public Health Institute, Kuopio, Finland

    Jouko Tuomisto

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