Abstract
Paraoxon, 0,0-diethyl-0-p-nitrophenylphosphate is the highly toxic metabolite of parathion. The activity of paraoxonase, the enzyme which hydrolyses paraoxon in human serum shows a genetically influenced polymorphism with strong interethnic differences. The serum paraoxonase genotype has a significant influence on the paraoxon clearance and consequently on the toxic action of paraoxon and some related organophosphates and definitively protects the serum cholinesterase. Persons with low paraoxonase activity seem to be more endangered when handling parathion and related insecticides. More than 50% of all Europeans can be included in this group. The distribution of paraoxonase activity in human serum will be shown for samples which were collected from all over the world. As one moves from Europe in the direction of Africa and Asia the percentage of the low activity group decreases and was not even demonstrable in some tribes.
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References
Carro-Ciampi G, Kadar D, Kalow W (1981) Distribution of serum paraoxon hydrolysing activities in a Canadian population. Can J Physiol Pharmacol 59: 904–910
Carro-Ciampi G, Gray S, Kalow W (1983) Paraoxonase phenotype distribution in Canadian Indian and Inuit populations. Can J Physiol Pharmacol 61: 336–340
Eckerson HW, Romson J, Wyte C, La Du BN (1983) The human serum paraoxonase polymorphism. Identification of phenotypes by their response to salts. Am J Hum Genet 35: 214–227
Eiberg H, Mohr J (1981) Genetics of paraoxonase. Ann Hum Genet 45: 323–330
Geldmacher-v. Mallinckrodt M, Rabast U, Lindorf HH (1969) Unterschiedliche Reaktion menschlicher Serum-Cholinesterase mit E 600. Arch Toxikol 25: 223–228
Geldmacher-v. Mallinckrodt M, Hommel G, Dumbach J (1979) On the genetics of the human serum paraoxonase (EC 3.1.1.2.). Hum Genet 50: 313–326
Geldmacher-v Mallinckrodt M, Diepgen TL, Duhme C, Hommel G (1983) A study of the polymorphism and ethnic distribution differences of human serum paraoxonase. Amer J Phys Anthropol 62: 235–241
Hommel G (1978) Estimation of the distribution of a genetically determined enzyme polymorphism by a stochastical outside criterion. Biometr J 20: 371–378
Hommel G, Duhme C, Diepgen TL (1980) GENITER: Computer program for the iteration of polymorphous enzyme activity distributions. Interner Arbeitsbericht Nr 180, University of Erlangen, Germany
Krisch K (1968) Enzymatische Hydrolyse von Diäthyl-p-nitrophenylphosphat durch menschliches Serum. Z Klin Chem Klin Biochem 6: 41–45
Mueller RF, Hornung S, Furlong CE, Anderson J, Giblett ER, Motulsky AG (1983) Plasma paraoxonase polymorphism: A new enzyme assay, population, family, biochemical, and linkage studies. Am J Hum Genet 35: 393–393
Playfer JR, Eze LC, Bullen MF, Evans DAP (1976) Genetic polymorphism and interethnic variability of plasma paraoxonase activity. J Med Genet 13: 337–342
Poore RE, Neal RA (1972) Evidence for extrahepatic metabolism of parathion. Toxicol Appl Pharmacol 23: 759–768
Zech R, Zuercher K (1974) Organophosphate splitting enzymes in different mammals. Comp Biochem Physiol (B) 48: 427–433
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© 1986 Springer-Verlag
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Diepgen, T.L., Geldmacher-v. Mallinckrodt, M. (1986). Interethnic Differences in the Detoxification of Organophosphates: The Human Serum Paraoxonase Polymorphism. In: Chambers, C.M., Chambers, P.L., Tuomisto, J. (eds) Toxic Interfaces of Neurones, Smoke and Genes. Archives of Toxicology, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71248-7_18
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DOI: https://doi.org/10.1007/978-3-642-71248-7_18
Publisher Name: Springer, Berlin, Heidelberg
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