Abstract
For the detection and quantitative assessment of cardiovascular toxicity, the morphological and biochemical studies used in routine toxicity tests must be supplemented with functional and metabolic measurements. Examples are given which show that the cardiotoxic effects of allylamine and emetine can be detected early by blood pressure and ECG monitoring. The same techniques are helpful in assessing potential drug interactions. For the hypoglycemic agent MTG measurement of mitochondrial function proved to be the most adequate method to demonstrate cardiotoxic hazard.
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References
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© 1986 Springer-Verlag
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Zbinden, G. (1986). Detection of Cardiotoxic Hazards. In: Chambers, C.M., Chambers, P.L., Tuomisto, J. (eds) Toxic Interfaces of Neurones, Smoke and Genes. Archives of Toxicology, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71248-7_23
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DOI: https://doi.org/10.1007/978-3-642-71248-7_23
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