Abstract
OR-K-242-HCl is an antitussive compound. Because it resembles lidocaine structurally, one of its target organs may be the heart. In anaesthetized guinea pigs OR-K-242-HCl depressed function of the heart. The aim of the present study was to test effects of OR-K-242-HC1 on the conduction velocity of the heart in the conscious beagle dog.
OR-K-242-HCl was administered 6 mg/kg and 12 mg/kg i.v. and 6 mg/kg, 12 mg/kg, 24 mg/kg, and 36 mg/kg orally. The doses for lidocaine (reference substance) were 6 mg/kg, and 12 mg/kg i.v. and 6 mg/kg, 12 mg/kg, and 24 mg/kg orally. Five consecutive noisefree cycles of ECG were used before and every 15 min up to three hours after the drug administrations. For each cycle PQ-, QTC-, RR-interval, as well as, QRS-complex and heart rate were calculated. Both OR-K-242-HCl and lidocaine prolonged the conduction velocity in the atria and ventricles. After i.v. and oral administration OR-K-242-HCl induced stronger and more uniform responses than lidocaine. The oral drug administrations produced more sustained responses than the intravenous injections for both compounds.
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References
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© 1986 Springer-Verlag
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Hanhijärvi, H., Voipio, HM., Huuskonen, H., Männistö, P., Nevalainen, T. (1986). Experimental Compound OR-K-242-HCl an Anilide Derivative Slows Conduction Velocity of the Heart in the Conscious Beagle Dog. In: Chambers, C.M., Chambers, P.L., Tuomisto, J. (eds) Toxic Interfaces of Neurones, Smoke and Genes. Archives of Toxicology, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71248-7_28
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DOI: https://doi.org/10.1007/978-3-642-71248-7_28
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-16589-7
Online ISBN: 978-3-642-71248-7
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