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To what Extent can Results of Experimental Studies be Extrapolated in Predicting Adverse Side Effects of Drugs in Man?

  • J. Grimová
  • Z. Roubal
  • A. Dlabač
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 9)

Abstract

A new potential antiinflammatory substance serves as an example that substantiates the necessity of carrying out concurrent comparative pharmacokinetic and biotransformation studies of new drugs in experimental animals and man during the preclinical research stage, with adherence to all safety precautions. Such a procedure will facilitate the choice of an animal model that approaches human metabolism and pharmacokinetics as closely as possible. This serves in the further development of the test drug, and thus enhances the validity of the transfer of experimental data to man, especially from the toxicological aspect.

Key words

Benzofenac Toxicology Pharmacokinetics Biotransformation 

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References

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • J. Grimová
    • 1
  • Z. Roubal
    • 1
  • A. Dlabač
    • 1
  1. 1.Research Institute for Pharmacy and BiochemistryKouřimská 17Czechoslovakia

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