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Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)

  • Book
  • © 2015

Overview

Editors:
  1. Caroline Fonta

    1. National Centre for Scientific Research (CNRS), University of Toulouse-UPS, Toulouse, France

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  2. László Négyessy

    1. Wigner Research Centre for Physics, Hungarian Academy of Sciences, Budapest, Hungary

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    You can also search for this editor in PubMed   Google Scholar

  • Offers a wealth of new information on alkaline phosphatase TNAP functions in the nervous system
  • Opens up new insights on the regulation of neural functions
  • A valuable resource for both researchers and clinicians
  • Includes supplementary material: sn.pub/extras

Part of the book series: Subcellular Biochemistry (SCBI, volume 76)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xxii
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  2. Disease Forms and Animal Models of Hypophosphatasia

    1. Front Matter

      Pages 1-1
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    2. Clinical Forms and Animal Models of Hypophosphatasia

      • Jean Pierre Salles
      Pages 3-24

    3. Molecular Genetics of Hypophosphatasia and Phenotype-Genotype Correlations

      • Etienne Mornet
      Pages 25-43

    4. Genetically Modified Mice for Studying TNAP Function

      • Sonoko Narisawa
      Pages 45-57

  3. Expression and Regulation of TNAP in the Central Nervous System

    1. Front Matter

      Pages 59-59
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    2. Tissue-Nonspecific Alkaline Phosphatase in the Developing Brain and in Adult Neurogenesis

      • Herbert Zimmermann, David Langer
      Pages 61-84

    3. Rediscovering TNAP in the Brain: A Major Role in Regulating the Function and Development of the Cerebral Cortex

      • Caroline Fonta, Pascal Barone, Laia Rodriguez Martinez, László Négyessy
      Pages 85-106

    4. The Retinal TNAP

      • Orsolya Kántor, Dorottya Cserpán, Béla Völgyi, Ákos Lukáts, Zoltán Somogyvári
      Pages 107-123

    5. Tissue Non-specific Alkaline Phosphatase (TNAP) in Vessels of the Brain

      • Barbara Deracinois, Anne-Marie Lenfant, Marie-Pierre Dehouck, Christophe Flahaut
      Pages 125-151

  4. TNAP Functions in the Nervous System

    1. Front Matter

      Pages 153-153
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    2. What Can We Learn About the Neural Functions of TNAP from Studies on Other Organs and Tissues?

      • José Luis Millán
      Pages 155-166

    3. TNAP, an Essential Player in Membrane Lipid Rafts of Neuronal Cells

      • Myriam Ermonval, Florence Baychelier, Caroline Fonta
      Pages 167-183

    4. Signal Transduction Pathways of TNAP: Molecular Network Analyses

      • László Négyessy, Balázs Györffy, János Hanics, Mihály Bányai, Caroline Fonta, Fülöp Bazsó
      Pages 185-205

    5. Vitamin B-6 Metabolism and Interactions with TNAP

      • Stephen P. Coburn
      Pages 207-238

    6. Tetramisole and Levamisole Suppress Neuronal Activity Independently from Their Inhibitory Action on Tissue Non-specific Alkaline Phosphatase in Mouse Cortex

      • Lionel G. Nowak, Benoît Rosay, Dávid Czégé, Caroline Fonta
      Pages 239-281

    7. TNAP and Pain Control

      • Sarah E. Street, Nathaniel A. Sowa
      Pages 283-305

  5. TNAP in Neurological Disorders

    1. Front Matter

      Pages 307-307
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    2. Neurological Symptoms of Hypophosphatasia

      • Takeshi Taketani
      Pages 309-322

    3. Recombinant Enzyme Replacement Therapy in Hypophosphatasia

      • Christine Hofmann, Franz Jakob, Lothar Seefried, Birgit Mentrup, Stephanie Graser, Horacio Plotkin et al.
      Pages 323-341
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Keywords

About this book

Phosphatases, such as TNAP are fundamental in regulating the roles of cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity. Regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer's disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. This book aims to provide an overview of our current understanding of the functions of TNAP in the brain and on other tissues and organs.

Editors and Affiliations

  • National Centre for Scientific Research (CNRS), University of Toulouse-UPS, Toulouse, France

    Caroline Fonta

  • Wigner Research Centre for Physics, Hungarian Academy of Sciences, Budapest, Hungary

    László Négyessy

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