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Signal Transduction Pathways of TNAP: Molecular Network Analyses

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Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)

Part of the book series: Subcellular Biochemistry ((SCBI,volume 76))

Abstract

Despite the growing body of evidence pointing on the involvement of tissue non-specific alkaline phosphatase (TNAP) in brain function and diseases like epilepsy and Alzheimer’s disease, our understanding about the role of TNAP in the regulation of neurotransmission is severely limited. The aim of our study was to integrate the fragmented knowledge into a comprehensive view regarding neuronal functions of TNAP using objective tools. As a model we used the signal transduction molecular network of a pyramidal neuron after complementing with TNAP related data and performed the analysis using graph theoretic tools. The analyses show that TNAP is in the crossroad of numerous pathways and therefore is one of the key players of the neuronal signal transduction network. Through many of its connections, most notably with molecules of the purinergic system, TNAP serves as a controller by funnelling signal flow towards a subset of molecules. TNAP also appears as the source of signal to be spread via interactions with molecules involved among others in neurodegeneration. Cluster analyses identified TNAP as part of the second messenger signalling cascade. However, TNAP also forms connections with other functional groups involved in neuronal signal transduction. The results indicate the distinct ways of involvement of TNAP in multiple neuronal functions and diseases.

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Acknowledgments

We are grateful to Dr M. Ermonval and Dr O. Kántor for suggestions on the manuscript.

Conflict of Interest The authors state no conflict of interest.

Author information

Authors and Affiliations

  1. Theoretical Neuroscience and Complex Systems Research Group, Wigner Research Center for Physics, Budapest, Hungary

    László Négyessy

  2. Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, 1094, Budapest, Hungary

    László Négyessy & János Hanics

  3. Laboratory of Proteomics and MTA-ELTE NAP B Neuroimmunology Research Group, Institute of Biology, Eötvös Loránd University, Budapest, Hungary

    Balázs Györffy

  4. Computational Systems Neuroscience Lab, Wigner Research Center for Physics, Hungarian Academy of Sciences, 1121, Budapest, Hungary

    Mihály Bányai

  5. Centre de Recherche Cerveau et Cognition (CerCo), Université de Toulouse UPS; CNRS UMR 5549, Toulouse, France

    Caroline Fonta

  6. Theoretical Neuroscience and Complex Systems Research Group, Wigner Research Center for Physics, Hungarian Academy of Sciences, Budapest, Hungary

    Fülöp Bazsó

  7. SU-Tech College of Applied Sciences, Subotica, Serbia

    Fülöp Bazsó

Authors
  1. László Négyessy
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  2. Balázs Györffy
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  3. János Hanics
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  4. Mihály Bányai
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  5. Caroline Fonta
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  6. Fülöp Bazsó
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Corresponding author

Correspondence to László Négyessy .

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Editors and Affiliations

  1. National Centre for Scientific Research (CNRS), University of Toulouse-UPS, Toulouse, France

    Caroline Fonta

  2. Wigner Research Centre for Physics, Hungarian Academy of Sciences, Budapest, Hungary

    László Négyessy

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Négyessy, L., Györffy, B., Hanics, J., Bányai, M., Fonta, C., Bazsó, F. (2015). Signal Transduction Pathways of TNAP: Molecular Network Analyses. In: Fonta, C., Négyessy, L. (eds) Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP). Subcellular Biochemistry, vol 76. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7197-9_10

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