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Clinical Benefits of Leukodepleted Blood Products

  • Joseph Sweeney
  • Andrew Heaton

Part of the Medical Intelligence Unit book series (MIUN)

Table of contents

  1. Front Matter
    Pages N2-x
  2. Joseph Sweeney, Andrew Heaton
    Pages 1-3
  3. Barry Wenz
    Pages 5-16
  4. Girolamo Sirchia, Paolo Rebulla
    Pages 17-27
  5. Ingeborg Steneker, Ruby N. I. Pietersz, Henk W. Reesink
    Pages 29-42
  6. Joseph D. Sweeney, Stein Holme, Andrew Heaton
    Pages 43-59
  7. Irena Sniecinski
    Pages 81-96
  8. Darrell J. Triulzi, Neil Blumberg
    Pages 113-127
  9. Naomi L. C. Luban, Louis DePalma
    Pages 153-165
  10. John M. Forbes, Maren A. Anderson, Steven A. Gould
    Pages 183-191
  11. Back Matter
    Pages 193-201

About this book

Introduction

Joseph Sweeney, Andrew Heaton he presence of allogeneic leukocytes in blood products received little T attention until the mid-1950s when these "passenger" cells were im­ plicated in the etiology of febrile transfusion reactions, and early strate­ gies based on centrifugation were developed to effect their removal. In recent decades and, particularly in the past five years, there has been an accumulation of literature implicating leukocytes in a wide variety of undesirable reactions to blood transfusion. White cells are the least numerous of the cellular elements in blood and ratios of white cells to platelets and white cells to red cells are ap­ proximately 1:15 to 1:1000 respectively. This ratio is maintained in whole blood, but may be altered slightly in the process of component prepara­ tion. Any production or processing step which intentionally decreases this ratio will result in a product which can be described as white cell depleted. It has, however, become more common to define the outcome as a residual white cell content, rather than a decrease in cellular ratios, although the latter makes more sense on theoretical grounds, since deple­ tion of white cells needs to be put in the context of any unintentional loss of red cells or platelets. The end result of this intentional processing step, therefore, is generally expressed as the residual absolute number of white cells or as the degree of difference in white cell content, the latter expressed as either a percentage change or as a logarithmic reduction.

Keywords

attention blood blood cell cell cells cytokine cytokines heart immunization immunomodulation lung production research stem cell viral infection

Authors and affiliations

  • Joseph Sweeney
    • 1
  • Andrew Heaton
    • 2
  1. 1.The Miriam and Roger Williams HospitalsProvidenceUSA
  2. 2.Irwin Memorial Blood CenterSan FranciscoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-26538-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-57059-122-8
  • Online ISBN 978-3-662-26538-3
  • Buy this book on publisher's site
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