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Clinical Benefits of Leukodepleted Blood Products pp 137–151Cite as

The Role of Leukocyte Depletion in the Prevention of Reperfusion Injury Associated with Open Heart Surgery

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Part of the book series: Medical Intelligence Unit ((MIUN))

Summary

Reperfusion injury (RI) is a term used to describe tissue injury associ-ated with revascularization after a period of ischaemia. This phenom-enon may occur in open heart surgery and result in considerable morbidity. The mechanism of RI is thought to be an interaction between activated leukocytes, and reperfused endothelium, resulting in the release of variety of substances, such as activated oxygen species or proteolytic enzymes, with potential for parenchymal damage.

Leukocyte activation occurs during cardiopulmonary bypass and strategies to minimize RI include minimizing organ underperfusion, improving the surfaces of the extracorporeal circuit so as to reduce cellular and protein activation, pharmacological agents such as steroids, radical scavengers or enzymes which remove activated oxygen species and leukodepletion of re-infused blood.

Leukodepletion of re-infused autologous blood or transfused allogeneic blood has become possible using in-line filtration. Leukodepletion of autologous blood can be achieved in both the extracorporeal perfusion circuit and the cardioplegia delivery system. Several early clinical studies indicated benefit of this approach in reducing postoperative morbidity, length of stay in the intensive care unit (ITU/ICU) and ventilation times.

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Authors
  1. Terry Gourlay
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  2. Kenneth M. Taylor
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© 1995 Springer-Verlag Berlin Heidelberg

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Gourlay, T., Taylor, K.M. (1995). The Role of Leukocyte Depletion in the Prevention of Reperfusion Injury Associated with Open Heart Surgery. In: Clinical Benefits of Leukodepleted Blood Products. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-26538-3_11

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  • DOI: https://doi.org/10.1007/978-3-662-26538-3_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-1-57059-122-8

  • Online ISBN: 978-3-662-26538-3

  • eBook Packages: Springer Book Archive

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