Risk Assessment of Prenatally-Induced Adverse Health Effects

  • Diether Neubert
  • Robert J. Kavlock
  • Hans-Joachim Merker
  • Jane Klein
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XIV
  2. Introduction

    1. Diether Neubert, Robert J. Kavlock
      Pages 1-23
  3. Basis for Testing in Reproductive Toxicity

    1. Front Matter
      Pages 25-25
    2. Jeanne M. Manson
      Pages 27-43
    3. Andrew C. Scallet, William Slikker Jr.
      Pages 63-77
    4. Ludwig Machemer, Ulrich Schmidt, Beate Holzum
      Pages 85-100
  4. Risk Assessment as Practiced in Various Countries

    1. Front Matter
      Pages 101-101
    2. Diether Neubert, Robert J. Kavlock, Hans-Joachim Merker, Jane Klein
      Pages 149-151
    3. Francisco J. R. Paumgartten, Eduardo E. Castilla, Roque Monteleone Neto, Helena L. L. Coelho, Sarah H. Costa
      Pages 163-179
    4. Diether Neubert, Robert J. Kavlock, Hans-Joachim Merker, Jane Klein
      Pages 191-194
  5. Dose-Response Relationships and Quantitative Risk Assessment

About these proceedings


Since the thalidomide (Contergan) tragedy about 30 years ago the induction of prenatally-induced morphological or functional defects has been an area of extensive research. Risk assessment of prenatally-induced adverse health effects is still a difficult task from both experimental data as well asfrom observations in humans. In the contributions to this book three major aspects are dealt with: - Quantitative extrapolations of experimental data to the situation possibly relevant for man. - The significance for a risk assessment with respect to man of minor or rare structural abnormalities observed in experimental studies - The future need to assess congenital dysfunctions (e.g. of the hormone or the immune system) beside the present evaulation of structural defects. Limitations as well as gaps of the present knowledge in this area of basic and applied research are pointed out. Since the results of prenatally-induced lesions may manifest themselves not only pre- but often not before late postnatally, numerous aspects of structural and functional abnormaldevelopment must be studied in experimental and clinical investigations.


Embryopharmacology Embryopharmakologie Embryotoxicology Embryotoxikologie research

Editors and affiliations

  • Diether Neubert
    • 1
  • Robert J. Kavlock
    • 2
  • Hans-Joachim Merker
    • 3
  • Jane Klein
    • 4
  1. 1.Institut für Toxikologie und EmbryopharmakologieUniversitätsklinikum Rudolf Virchow, Freie Universität BerlinBerlin 33Germany
  2. 2.Developmental Toxicology DivisionUS Environmental Protection Agency, Health Effects Research Laboratory (MD-71)USA
  3. 3.Institut für AnatomieFreie Universität BerlinBerlin 33Germany
  4. 4.Institut für Toxikologie und EmbryopharmakologieFreie Universität BerlinBerlin 33Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-77753-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1992
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-77755-4
  • Online ISBN 978-3-642-77753-0
  • About this book
Industry Sectors
Health & Hospitals