Statistical Problems (and Some Solutions) Associated with Testing for Effects in Developmental Toxicology

  • R. Woodrow Setzer

Abstract

We have come a long way in testing for effects in developmental toxicology since the debates over the “unit of observation” in teratology (Weil 1970; Kalter 1974; Staples and Haseman 1974; Becker 1974; Haseman and Hogan 1975). Much of the recent biostatistical work on testing has been on devising powerful statistical tests that reflect the proper choice for the unit of observation. This paper will review some of the statistical problems posed by developmental toxicology data as well as principal solutions posed for some of those problems. Included in the review are several simple new methods that have yet to be applied in this field. The analysis of developmental toxicology data would be improved through increased utilization of biological content that these new approaches offer.

Keywords

Toxicity Depression Assure Hydrocephalus Salicylate 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

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  • R. Woodrow Setzer

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