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A Call for Increased Flexibility in Current Teratogenicity Testing

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Risk Assessment of Prenatally-Induced Adverse Health Effects

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Abstract

The testing of new drugs and chemicals for the potential risk they might pose for the human population is a very difficult proposition. In the field of developmental toxicity this task is more difficult due to the added complexity of species differences in embryogenesis and the placental interface.

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References

  • Hirsch KS, Scott WJ (1983) Searching for the mechanism of acetazolamide teratogenesis. In: H. Kalter (ed), Issues and Reviews in Teratology, Plenum Press, New York, pp 309–347.

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  • Wilson JG (1975) Critique of current methods for teratogenicity testing in animals and suggestions for their improvement. In: T. Shepard, J. Miller, M. Marois (eds), Methods for detection of environmental agents that produce congenital defects, North-Holland/American Elsevier, New York, pp 29–57.

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  • Wilson JG, Maren TH, Takano K, Ellison A (1968) Teratogenic action of carbonic anhydrase inhibitors in the rat. Teratology 1: 51–60.

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Authors
  1. William J. Scott Jr.
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Editor information

Editors and Affiliations

  1. Institut für Toxikologie und Embryopharmakologie, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Garystrasse 5, W-1000, Berlin 33, Germany

    Diether Neubert

  2. Developmental Toxicology Division, US Environmental Protection Agency, Health Effects Research Laboratory (MD-71), Research Triangle Park, NC, 27711, USA

    Robert J. Kavlock (Director) (Director)

  3. Institut für Anatomie, Freie Universität Berlin, Königin-Luise-Strasse 15, W-1000, Berlin 33, Germany

    Hans-Joachim Merker

  4. Institut für Toxikologie und Embryopharmakologie, Freie Universität Berlin, Garystrasse 5, W-1000, Berlin 33, Germany

    Jane Klein

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© 1992 Springer-Verlag Berlin Heidelberg

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Scott, W.J. (1992). A Call for Increased Flexibility in Current Teratogenicity Testing. In: Neubert, D., Kavlock, R.J., Merker, HJ., Klein, J. (eds) Risk Assessment of Prenatally-Induced Adverse Health Effects. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77753-0_5

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  • DOI: https://doi.org/10.1007/978-3-642-77753-0_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77755-4

  • Online ISBN: 978-3-642-77753-0

  • eBook Packages: Springer Book Archive

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