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A Call for Increased Flexibility in Current Teratogenicity Testing

  • William J. ScottJr.
Conference paper

Abstract

The testing of new drugs and chemicals for the potential risk they might pose for the human population is a very difficult proposition. In the field of developmental toxicity this task is more difficult due to the added complexity of species differences in embryogenesis and the placental interface.

Keywords

Cytosine Arabinoside Developmental Toxicity Pragmatic Consideration Hazard Identification Limb Malformation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Hirsch KS, Scott WJ (1983) Searching for the mechanism of acetazolamide teratogenesis. In: H. Kalter (ed), Issues and Reviews in Teratology, Plenum Press, New York, pp 309–347.Google Scholar
  2. Layton WM, Hallesy D (1965) Deformity of forelimb in rats; association with high doses of acetazolamide. Science 149: 306–308.PubMedCrossRefGoogle Scholar
  3. Scott W, Duggan C, Schreiner C, Collins M (1990) Reduction of embryonic intracellular pH: a potential mechanism of acetazolamide-induced limb malformations. Toxicol Appl Pharmacol 103: 238–254.PubMedCrossRefGoogle Scholar
  4. Wilson JG (1975) Critique of current methods for teratogenicity testing in animals and suggestions for their improvement. In: T. Shepard, J. Miller, M. Marois (eds), Methods for detection of environmental agents that produce congenital defects, North-Holland/American Elsevier, New York, pp 29–57.Google Scholar
  5. Wilson JG, Maren TH, Takano K, Ellison A (1968) Teratogenic action of carbonic anhydrase inhibitors in the rat. Teratology 1: 51–60.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • William J. ScottJr.

There are no affiliations available

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