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Fundamental Aspects of Neoplasia

  • Book
  • © 1975

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Editors:
  1. A. Arthur Gottlieb

    1. Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, USA

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  2. Otto J. Plescia

    1. Institute of Microbiology, Rutgers University, New Brunswick, USA

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  3. David H. L. Bishop

    1. The Medical Center, University of Alabama, Birmingham, USA

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Table of contents (32 chapters)

  1. Front Matter

    Pages i-xxiv
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  2. Biology of Tumor Viruses

    1. Front Matter

      Pages 1-1
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    2. On the Evidence for Type-C RNA Tumor Virus Information and Virus-Related Reverse Transcriptase in Animals and in Human Leukemia Cells

      • D. Gillespie, R. E. Gallagher, R. G. Smith, W. C. Saxinger, R. C. Gallo
      Pages 3-27

    3. Evolution of Primate Type-C Viral Genes

      • R. E. Benveniste, C. J. Sherr, M. M. Lieber, R. Callahan, G. J. Todaro
      Pages 29-53

    4. The Mammary Tumor Viruses

      • D. H. Moore
      Pages 55-59

    5. Biochemical Evidence for Viral Involvement in Human Breast Cancer

      • J. Schlom, D. Colcher, R. Michalides, G. Schochetman, J. Young, S. Spiegelman et al.
      Pages 61-78

  3. Tumor Immunology

    1. Front Matter

      Pages 79-79
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    2. Immunologic Properties of Cell Surface Antigens Induced by RNA Tumor Viruses

      • H. Bauer, R. Kurth, H. Gelderblom
      Pages 81-88

    3. Studies on the Mechanisms of Tumor Immunity: Some Recent Data on Cellular Immunity to Common, Possibly Embryonic Antigens in Mouse Sarcomas

      • K. E. Hellström, I. Hellström
      Pages 89-99

    4. Escape from Immune Control by the Shedding of Membrane Antigens: Influence on Metastatic Behavior of Tumor Cells

      • P. Alexander
      Pages 101-108

    5. Expression of HL-A Antigens on Lymphoblastoid Cells

      • R. A. Reisfeld, M. A. Pellegrino, S. Ferrone, S. Oh
      Pages 109-121

    6. Inhibitory Action of Poly A: Poly U on Tumor Growth: Enhancement of Host Immune Response?

      • F. Lacour, G. Delage, E. Fenster, J. Harel
      Pages 123-138

    7. The Problem of Cancer Immunotherapy in Perspective

      • O. J. Plescia, A. Smith, K. Grinwich, C. Feit
      Pages 139-151

  4. Clinical Aspects

    1. Front Matter

      Pages 153-153
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    2. Immunotherapy of Cancer: Concepts and Problems

      • C. F. McKhann
      Pages 155-161

    3. Chemotherapy, Supportive Care, and Immunotherapy of Cancer—from Research Tools to Therapeutic Modalities

      • I. Djerassi, J. Sun Kim, U. Suvansri
      Pages 163-180

    4. Immunologic and Clinical Responses to Active Immunotherapy of Malignant Melanoma

      • D. L. Morton, S. H. Golub, H. L. Sulit, R. K. Gupta, F. R. Eilber, E. C. Holmes et al.
      Pages 181-201

    5. Viral Etiology of Human Osteosarcoma: Evidence Based on Response to Tumor-Specific Transfer Factor and on Immunoepidemiologic Studies

      • H. H. Fudenberg, V. S. Byers, A. S. Levin
      Pages 203-212

    6. Evidence for RNA Virus Associated with Human Transitional Cell Cancers of the Urinary Tract

      • E. E. Fraley, A. Y. Elliott, A. E. Castro, P. H. Cleveland, D. L. Bronson, T. R. Hakala et al.
      Pages 213-228

    7. Trials with Poly A:Poly U as Adjuvant Therapy Complementing Surgery in Randomized Patients with Breast Cancer

      • J. Lacour
      Pages 229-232
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Keywords

About this book

The control of cancer is at once a major public health problem and a problem of fundamental biologic interest. As a result of technologic developments and new insights in the realm of molecular biology, new and important approaches to an understanding of neoplasia are now possible. Several aspects of neoplasia are clearly of microbiologic interest, including the role of viruses in the etiology of cancer, control of the immune response to tumor cells, and the susceptibility of tumor-bearing hosts to overwhelming infection as a result of immuno­ deficiency. Recent advances in these areas led us to organize this symposium, and, through this publication, to record some of the progress being made in laboratories around the world in understanding some of the basic aspects of the cancer problem. This symposium was held as part of the commemoration of the twentieth anniversary of the Waksman Institute of Microbiology. Dr. Waksman's devo­ tion to the study of the smallest forms of life and the commitment of the Waksman Institute to the free pursuit of knowledge are the underpinnings of the institute's research eHorts in the broad area of microbiology, including the problem of neoplasia. It is of interest to note that actinomycin, one of the earliest antibiotics discovered in Waksman's laboratory, was also one of the first compounds found to be clinically useful in the treatment of certain types of cancer.

Editors and Affiliations

  • Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, USA

    A. Arthur Gottlieb

  • Institute of Microbiology, Rutgers University, New Brunswick, USA

    Otto J. Plescia

  • The Medical Center, University of Alabama, Birmingham, USA

    David H. L. Bishop

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