Immunologic Properties of Cell Surface Antigens Induced by RNA Tumor Viruses
Since it is now recognized that surface interactions strongly influence the social behavior of cells, the expression of new macromolecules on the tumor cell surface, which can be detected by immunologic means, may be a key phenomenon in the process of malignant transformation of a cell. Also, further studies of the immunologic, biochemical, and biosynthetic reactions of tumor-specific, cell surface antigens (TSSA) could lead to a better understanding of this transformation and, hence, carcinogenesis. On the other hand, TSSA that are foreign to the tumor-bearing host and that can generally provoke an immunologic defense reaction could lead to techniques useful in the prevention or cure of cancer by immunologic means.
KeywordsCell Surface Antigen Embryonic Antigen Avian Leukosis Virus Untransformed Cell Chick Embryo Fibroblast
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